hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_03368.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UGT1A5 | UDP-glucuronosyltransferase 1A5 (UGT1A5) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-5) (UDPGT 1-5) (UGT1*5) (UGT1-05) (UGT1.5) (UDP-glucuronosyltransferase 1-E) (UGT-1E) (UGT1E) | 5 | UniProt NCBI |
| UGT1A3 | UDP-glucuronosyltransferase 1A3 (UGT1A3) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-3) (UDPGT 1-3) (UGT1*3) (UGT1-03) (UGT1.3) (UDP-glucuronosyltransferase 1-C) (UGT-1C) (UGT1C) (UDP-glucuronosyltransferase 1A isoform 3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00053 | 3.75535994234e-05 | 1.0 | UGT1A5 UGT1A3 | Ascorbate and aldarate metabolism |
| KEGG:00040 | 4.8770908342e-05 | 1.0 | UGT1A5 UGT1A3 | Pentose and glucuronate interconversions |
| WP:WP698 | 6.51224637934e-05 | 1.0 | UGT1A5 UGT1A3 | Glucuronidation |
| KEGG:00860 | 8.58367986819e-05 | 1.0 | UGT1A5 UGT1A3 | Porphyrin metabolism |
| KEGG:00140 | 0.000126804361689 | 1.0 | UGT1A5 UGT1A3 | Steroid hormone biosynthesis |
| REAC:R-HSA-156588 | 0.000205051410255 | 1.0 | UGT1A5 UGT1A3 | Glucuronidation |
| KEGG:00830 | 0.000207276360454 | 1.0 | UGT1A5 UGT1A3 | Retinol metabolism |
| KEGG:05204 | 0.000224021038984 | 1.0 | UGT1A5 UGT1A3 | Chemical carcinogenesis - DNA adducts |
| KEGG:00982 | 0.000232637232791 | 1.0 | UGT1A5 UGT1A3 | Drug metabolism - cytochrome P450 |
| KEGG:04976 | 0.000268727704965 | 1.0 | UGT1A5 UGT1A3 | Bile secretion |
| KEGG:00980 | 0.000278156747244 | 1.0 | UGT1A5 UGT1A3 | Metabolism of xenobiotics by cytochrome P450 |
| KEGG:00983 | 0.000359441594481 | 1.0 | UGT1A5 UGT1A3 | Drug metabolism - other enzymes |
| REAC:R-HSA-9749641 | 0.000743311362176 | 1.0 | UGT1A5 UGT1A3 | Aspirin ADME |
| KEGG:01240 | 0.00144865854745 | 1.0 | UGT1A5 UGT1A3 | Biosynthesis of cofactors |
| KEGG:05207 | 0.00214640767613 | 1.0 | UGT1A5 UGT1A3 | Chemical carcinogenesis - receptor activation |
| WP:WP702 | 0.00384988683014 | 1.0 | UGT1A5 UGT1A3 | Metapathway biotransformation Phase I and II |
| REAC:R-HSA-156580 | 0.00539968713673 | 1.0 | UGT1A5 UGT1A3 | Phase II - Conjugation of compounds |
| REAC:R-HSA-9748784 | 0.0055363880769 | 1.0 | UGT1A5 UGT1A3 | Drug ADME |
| REAC:R-HSA-211859 | 0.0225607814134 | 1.0 | UGT1A5 UGT1A3 | Biological oxidations |
| TF:M06054 | 0.0426062655276 | 1.0 | UGT1A5 UGT1A3 | Factor: ZNF99; motif: KGKTGAGGAMCA |
| GO:0052695 | 0.0426062655276 | 1.0 | UGT1A5 UGT1A3 | cellular glucuronidation |
| GO:0019585 | 0.0491610756088 | 1.0 | UGT1A5 UGT1A3 | glucuronate metabolic process |
| GO:0006063 | 0.0491610756088 | 1.0 | UGT1A5 UGT1A3 | uronic acid metabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| UGT1A5 | UGT1A3 | 0.982 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| UGT1A5 | huMAP3_03368.1 huMAP3_06256.1 |
| UGT1A3 | huMAP3_03368.1 |