hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03371.1
Complex Portal: CPX-16592
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| VPS8 | Vacuolar protein sorting-associated protein 8 homolog | 5 | UniProt NCBI |
| VPS39 | Vam6/Vps39-like protein (TRAP1-like protein) (hVam6p) | 5 | UniProt NCBI |
| VPS11 | Vacuolar protein sorting-associated protein 11 homolog (hVPS11) (RING finger protein 108) | 5 | UniProt NCBI |
| TGFBRAP1 | Transforming growth factor-beta receptor-associated protein 1 (TGF-beta receptor-associated protein 1) (TRAP-1) (TRAP1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0034058 | 1.58598067776e-05 | 1.0 | VPS39 VPS8 TGFBRAP1 | endosomal vesicle fusion |
| KEGG:04148 | 1.62006150102e-05 | 1.0 | VPS39 VPS8 TGFBRAP1 | Efferocytosis |
| GO:0035542 | 2.11464090368e-05 | 1.0 | VPS39 VPS8 TGFBRAP1 | regulation of SNARE complex assembly |
| CORUM:6388 | 3.41705576683e-05 | 0.666666666667 | TGFBRAP1 VPS8 | CORVET complex |
| GO:0035493 | 7.84339535184e-05 | 1.0 | VPS39 VPS8 TGFBRAP1 | SNARE complex assembly |
| GO:0099023 | 0.00345936027834 | 1.0 | VPS39 VPS8 TGFBRAP1 | vesicle tethering complex |
| GO:0006906 | 0.0112921824257 | 1.0 | VPS39 VPS8 TGFBRAP1 | vesicle fusion |
| GO:0090174 | 0.0120707547584 | 1.0 | VPS39 VPS8 TGFBRAP1 | organelle membrane fusion |
| GO:0033263 | 0.0210651876021 | 0.666666666667 | TGFBRAP1 VPS8 | CORVET complex |
| GO:0048284 | 0.0283784809274 | 1.0 | VPS39 VPS8 TGFBRAP1 | organelle fusion |
| GO:0061025 | 0.0335943388364 | 1.0 | VPS39 VPS8 TGFBRAP1 | membrane fusion |
| GO:0007034 | 0.0360123345897 | 1.0 | VPS39 VPS8 TGFBRAP1 | vacuolar transport |
| CORUM:6118 | 0.0499402709677 | 0.333333333333 | VPS39 | Hook1-Vps39 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| VPS11 | TGFBRAP1 | 1.0 | 0.618 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| VPS39 | VPS11 | 1.0 | 0.192 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | |
| VPS8 | VPS11 | 0.997 | 0.632 | hein_WMM bioplex3_WMM hein () | |
| VPS8 | TGFBRAP1 | 0.997 | 0.734 |
structurally_consistent (Q9P253)
|
hein_WMM bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| VPS39 | TGFBRAP1 | 0.937 | 0.22 | bioplex_WMM bioplex3_WMM WMM_only | |
| VPS39 | VPS8 | 0.055 | 0.13 |
structurally_consistent (Q9P253)
|
bioplex3_WMM WMM_only |
Related Complexes