hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_03388.1
Complex Portal: CPX-23522
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RRM2 | Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1) (Ribonucleotide reductase small chain) (Ribonucleotide reductase small subunit) | 5 | UniProt NCBI |
| GNPTAB | N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (EC 2.7.8.17) (GlcNAc-1-phosphotransferase subunits alpha/beta) (Stealth protein GNPTAB) (UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta) [Cleaved into: N-acetylglucosamine-1-phosphotransferase subunit alpha; N-acetylglucosamine-1-phosphotransferase subunit beta] | 5 | UniProt NCBI |
| BUB1B | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | 5 | UniProt NCBI |
| ANAPC16 | Anaphase-promoting complex subunit 16 (APC16) (Cyclosome subunit 16) | 5 | UniProt NCBI |
| FZR1 | Fizzy-related protein homolog (Fzr) (CDC20-like protein 1) (Cdh1/Hct1 homolog) (hCDH1) | 5 | UniProt NCBI |
| CDC20 | Cell division cycle protein 20 homolog (p55CDC) | 5 | UniProt NCBI |
| ANAPC15 | Anaphase-promoting complex subunit 15 (APC15) | 5 | UniProt NCBI |
| CDC23 | Cell division cycle protein 23 homolog (Anaphase-promoting complex subunit 8) (APC8) (Cyclosome subunit 8) | 5 | UniProt NCBI |
| ANAPC13 | Anaphase-promoting complex subunit 13 (APC13) (Cyclosome subunit 13) | 4 | UniProt NCBI |
| CDC16 | Cell division cycle protein 16 homolog (Anaphase-promoting complex subunit 6) (APC6) (CDC16 homolog) (CDC16Hs) (Cyclosome subunit 6) | 5 | UniProt NCBI |
| NEK2 | Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (HSPK 21) (Never in mitosis A-related kinase 2) (NimA-related protein kinase 2) (NimA-like protein kinase 1) | 5 | UniProt NCBI |
| ANAPC10 | Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10) | 5 | UniProt NCBI |
| CDC26 | Anaphase-promoting complex subunit CDC26 (Anaphase-promoting complex subunit 12) (APC12) (Cell division cycle protein 26 homolog) | 5 | UniProt NCBI |
| ANAPC7 | Anaphase-promoting complex subunit 7 (APC7) (Cyclosome subunit 7) | 5 | UniProt NCBI |
| ANAPC4 | Anaphase-promoting complex subunit 4 (APC4) (Cyclosome subunit 4) | 5 | UniProt NCBI |
| ANAPC1 | Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) | 5 | UniProt NCBI |
| CDC27 | Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC) | 5 | UniProt NCBI |
| ANAPC5 | Anaphase-promoting complex subunit 5 (APC5) (Cyclosome subunit 5) | 5 | UniProt NCBI |
| CFAP97 | Cilia- and flagella-associated protein 97 | 3 | UniProt NCBI |
| ANAPC2 | Anaphase-promoting complex subunit 2 (APC2) (Cyclosome subunit 2) | 5 | UniProt NCBI |
| FBXO5 | F-box only protein 5 (Early mitotic inhibitor 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0005680 | 1.86520762804e-37 | 0.75 | ANAPC15 BUB1B CDC26 ANAPC10 ANAPC16 ANAPC5 FZR1 ANAPC4 CDC23 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 ANAPC13 | anaphase-promoting complex |
| REAC:R-HSA-179409 | 2.31050107979e-34 | 0.7 | ANAPC15 BUB1B CDC26 NEK2 ANAPC16 ANAPC5 ANAPC4 ANAPC1 CDC23 CDC16 CDC20 ANAPC7 ANAPC2 ANAPC10 | APC-Cdc20 mediated degradation of Nek2A |
| GO:0031145 | 2.67170337518e-33 | 0.7 | ANAPC15 ANAPC10 CDC26 ANAPC16 ANAPC5 FZR1 ANAPC4 ANAPC13 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 CDC23 | anaphase-promoting complex-dependent catabolic process |
| REAC:R-HSA-176407 | 2.93828193062e-33 | 0.65 | ANAPC15 ANAPC10 CDC26 ANAPC16 FZR1 ANAPC4 CDC23 CDC16 CDC20 ANAPC5 ANAPC1 ANAPC2 ANAPC7 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| REAC:R-HSA-141430 | 8.39135281922e-33 | 0.65 | ANAPC15 BUB1B CDC26 ANAPC16 ANAPC5 ANAPC4 ANAPC1 CDC23 CDC16 CDC20 ANAPC7 ANAPC2 ANAPC10 | Inactivation of APC/C via direct inhibition of the APC/C complex |
| REAC:R-HSA-141405 | 8.39135281922e-33 | 0.65 | ANAPC15 BUB1B CDC26 ANAPC16 ANAPC5 ANAPC4 ANAPC1 CDC23 CDC16 CDC20 ANAPC7 ANAPC2 ANAPC10 | Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| GO:0051445 | 8.59176980664e-32 | 0.75 | ANAPC15 FBXO5 ANAPC10 CDC26 ANAPC16 ANAPC5 FZR1 ANAPC4 ANAPC13 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 CDC23 | regulation of meiotic cell cycle |
| REAC:R-HSA-174143 | 6.95444367444e-31 | 0.8 | ANAPC15 FBXO5 BUB1B CDC26 NEK2 ANAPC16 ANAPC5 FZR1 ANAPC4 CDC23 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 ANAPC10 | APC/C-mediated degradation of cell cycle proteins |
| REAC:R-HSA-453276 | 6.95444367444e-31 | 0.8 | ANAPC15 FBXO5 BUB1B CDC26 NEK2 ANAPC16 ANAPC5 FZR1 ANAPC4 CDC23 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 ANAPC10 | Regulation of mitotic cell cycle |
| GO:0000152 | 7.84450089498e-31 | 0.75 | ANAPC15 BUB1B CDC26 ANAPC10 ANAPC16 ANAPC5 FZR1 ANAPC4 CDC23 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 ANAPC13 | nuclear ubiquitin ligase complex |
| REAC:R-HSA-9687136 | 9.95206611818e-30 | 0.6 | ANAPC15 ANAPC10 CDC26 ANAPC16 FZR1 ANAPC4 CDC23 CDC16 ANAPC5 ANAPC1 ANAPC2 ANAPC7 | Aberrant regulation of mitotic exit in cancer due to RB1 defects |
| REAC:R-HSA-176408 | 1.12980761344e-28 | 0.75 | ANAPC15 FBXO5 BUB1B CDC26 ANAPC16 ANAPC5 FZR1 ANAPC4 CDC23 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 ANAPC10 | Regulation of APC/C activators between G1/S and early anaphase |
| REAC:R-HSA-174048 | 2.66507065283e-28 | 0.6 | ANAPC15 ANAPC10 CDC26 ANAPC16 ANAPC4 ANAPC1 CDC23 CDC16 CDC20 ANAPC5 ANAPC2 ANAPC7 | APC/C:Cdc20 mediated degradation of Cyclin B |
| KEGG:04110 | 2.0903501628e-27 | 0.8 | ANAPC15 FBXO5 BUB1B CDC26 ANAPC10 ANAPC16 ANAPC5 FZR1 ANAPC4 CDC23 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 ANAPC13 | Cell cycle |
| REAC:R-HSA-179419 | 1.52122573295e-26 | 0.7 | ANAPC15 BUB1B CDC26 NEK2 ANAPC16 ANAPC5 ANAPC4 ANAPC1 CDC23 CDC16 CDC20 ANAPC7 ANAPC2 ANAPC10 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint |
| REAC:R-HSA-176409 | 2.31958643285e-26 | 0.7 | ANAPC15 BUB1B CDC26 NEK2 ANAPC16 ANAPC5 ANAPC4 ANAPC1 CDC23 CDC16 CDC20 ANAPC7 ANAPC2 ANAPC10 | APC/C:Cdc20 mediated degradation of mitotic proteins |
| REAC:R-HSA-176412 | 2.4199598212e-26 | 0.55 | CDC26 ANAPC10 ANAPC15 ANAPC16 ANAPC4 ANAPC1 CDC23 CDC16 ANAPC5 ANAPC2 ANAPC7 | Phosphorylation of the APC/C |
| REAC:R-HSA-176814 | 2.85085259185e-26 | 0.7 | ANAPC15 BUB1B CDC26 NEK2 ANAPC16 ANAPC5 ANAPC4 ANAPC1 CDC23 CDC16 CDC20 ANAPC7 ANAPC2 ANAPC10 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins |
| REAC:R-HSA-9687139 | 1.63481834586e-25 | 0.6 | ANAPC15 ANAPC10 CDC26 ANAPC16 FZR1 ANAPC4 CDC23 CDC16 ANAPC5 ANAPC1 ANAPC2 ANAPC7 | Aberrant regulation of mitotic cell cycle due to RB1 defects |
| GO:2000241 | 3.12065900263e-25 | 0.75 | ANAPC15 FBXO5 ANAPC10 CDC26 ANAPC16 ANAPC5 FZR1 ANAPC4 ANAPC13 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 CDC23 | regulation of reproductive process |
| REAC:R-HSA-9675126 | 3.62562181626e-25 | 0.6 | ANAPC15 ANAPC10 CDC26 ANAPC16 FZR1 ANAPC4 CDC23 CDC16 ANAPC5 ANAPC1 ANAPC2 ANAPC7 | Diseases of mitotic cell cycle |
| REAC:R-HSA-8853884 | 3.62562181626e-25 | 0.6 | ANAPC15 ANAPC10 CDC26 ANAPC16 FZR1 ANAPC4 CDC23 CDC16 ANAPC5 ANAPC1 ANAPC2 ANAPC7 | Transcriptional Regulation by VENTX |
| KEGG:04114 | 7.7092648294e-25 | 0.7 | ANAPC15 FBXO5 ANAPC10 CDC26 ANAPC16 ANAPC5 ANAPC4 ANAPC1 ANAPC13 CDC16 CDC20 ANAPC7 ANAPC2 CDC23 | Oocyte meiosis |
| REAC:R-HSA-174184 | 6.14820713516e-24 | 0.65 | ANAPC15 BUB1B CDC26 ANAPC16 ANAPC5 ANAPC4 ANAPC1 CDC23 CDC16 CDC20 ANAPC7 ANAPC2 ANAPC10 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A |
| REAC:R-HSA-174178 | 7.49954498959e-24 | 0.65 | ANAPC15 ANAPC10 CDC26 ANAPC16 FZR1 ANAPC4 CDC23 CDC16 CDC20 ANAPC5 ANAPC1 ANAPC2 ANAPC7 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| KEGG:04914 | 9.05691652978e-24 | 0.65 | ANAPC15 ANAPC10 CDC26 ANAPC16 ANAPC5 FZR1 ANAPC4 ANAPC13 CDC16 ANAPC7 ANAPC1 ANAPC2 CDC23 | Progesterone-mediated oocyte maturation |
| KEGG:04120 | 3.65261310175e-23 | 0.7 | ANAPC15 ANAPC10 CDC26 ANAPC16 ANAPC5 FZR1 ANAPC4 ANAPC13 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 CDC23 | Ubiquitin mediated proteolysis |
| CORUM:96 | 8.92233886548e-23 | 0.4 | ANAPC10 CDC16 ANAPC1 ANAPC4 ANAPC7 ANAPC2 ANAPC5 CDC23 | Anaphase-promoting complex |
| GO:0007346 | 2.75664023348e-22 | 0.9 | ANAPC15 CDC16 FBXO5 BUB1B CDC26 NEK2 ANAPC10 ANAPC16 ANAPC5 FZR1 ANAPC4 CDC23 CDC20 RRM2 ANAPC7 ANAPC1 ANAPC2 ANAPC13 | regulation of mitotic cell cycle |
| REAC:R-HSA-174084 | 5.15416876827e-22 | 0.6 | ANAPC15 ANAPC10 CDC26 ANAPC16 FZR1 ANAPC4 CDC23 CDC16 ANAPC5 ANAPC1 ANAPC2 ANAPC7 | Autodegradation of Cdh1 by Cdh1:APC/C |
| REAC:R-HSA-174154 | 9.4942753243e-22 | 0.6 | ANAPC15 ANAPC10 CDC26 ANAPC16 ANAPC4 ANAPC1 CDC23 CDC16 CDC20 ANAPC5 ANAPC2 ANAPC7 | APC/C:Cdc20 mediated degradation of Securin |
| GO:0051321 | 9.90500925523e-22 | 0.75 | ANAPC15 FBXO5 ANAPC10 CDC26 ANAPC16 ANAPC5 FZR1 ANAPC4 ANAPC13 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 CDC23 | meiotic cell cycle |
| GO:0070979 | 1.10134147575e-21 | 0.55 | ANAPC10 CDC16 ANAPC5 FZR1 ANAPC4 ANAPC13 CDC26 ANAPC7 ANAPC1 ANAPC2 CDC23 | protein K11-linked ubiquitination |
| REAC:R-HSA-69618 | 2.14322364015e-21 | 0.65 | ANAPC15 BUB1B CDC26 ANAPC16 ANAPC5 ANAPC4 ANAPC1 CDC23 CDC16 CDC20 ANAPC7 ANAPC2 ANAPC10 | Mitotic Spindle Checkpoint |
| REAC:R-HSA-69017 | 2.4628804265e-21 | 0.6 | ANAPC15 ANAPC10 CDC26 ANAPC16 FZR1 ANAPC4 CDC23 CDC16 ANAPC5 ANAPC1 ANAPC2 ANAPC7 | CDK-mediated phosphorylation and removal of Cdc6 |
| GO:0031461 | 3.46241098191e-21 | 0.75 | ANAPC15 BUB1B CDC26 ANAPC10 ANAPC16 ANAPC5 FZR1 ANAPC4 CDC23 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 ANAPC13 | cullin-RING ubiquitin ligase complex |
| KEGG:05166 | 9.5361517527e-21 | 0.7 | ANAPC15 BUB1B CDC26 ANAPC10 ANAPC16 ANAPC5 ANAPC4 ANAPC1 ANAPC13 CDC16 CDC20 ANAPC7 ANAPC2 CDC23 | Human T-cell leukemia virus 1 infection |
| REAC:R-HSA-69052 | 5.21840288723e-20 | 0.6 | ANAPC15 ANAPC10 CDC26 ANAPC16 FZR1 ANAPC4 CDC23 CDC16 ANAPC5 ANAPC1 ANAPC2 ANAPC7 | Switching of origins to a post-replicative state |
| REAC:R-HSA-69278 | 7.09842854547e-20 | 0.85 | ANAPC15 CDC16 FBXO5 BUB1B CDC26 NEK2 ANAPC16 ANAPC5 FZR1 ANAPC4 CDC23 CDC20 RRM2 ANAPC7 ANAPC1 ANAPC2 ANAPC10 | Cell Cycle, Mitotic |
| CORUM:93 | 1.00259635498e-19 | 0.35 | ANAPC5 CDC16 ANAPC1 ANAPC4 CDC23 ANAPC2 ANAPC7 | Anaphase-promoting complex |
| REAC:R-HSA-2559582 | 1.35333914035e-19 | 0.6 | ANAPC15 ANAPC10 CDC26 ANAPC16 FZR1 ANAPC4 CDC23 CDC16 ANAPC5 ANAPC1 ANAPC2 ANAPC7 | Senescence-Associated Secretory Phenotype (SASP) |
| REAC:R-HSA-2555396 | 2.91217934115e-19 | 0.7 | ANAPC15 FBXO5 BUB1B CDC26 ANAPC16 ANAPC5 ANAPC4 ANAPC1 CDC23 CDC16 CDC20 ANAPC7 ANAPC2 ANAPC10 | Mitotic Metaphase and Anaphase |
| REAC:R-HSA-69239 | 1.78132880723e-18 | 0.6 | ANAPC15 ANAPC10 CDC26 ANAPC16 FZR1 ANAPC4 CDC23 CDC16 ANAPC5 ANAPC1 ANAPC2 ANAPC7 | Synthesis of DNA |
| REAC:R-HSA-1640170 | 2.45808216517e-18 | 0.85 | ANAPC15 CDC16 FBXO5 BUB1B CDC26 NEK2 ANAPC16 ANAPC5 FZR1 ANAPC4 CDC23 CDC20 RRM2 ANAPC7 ANAPC1 ANAPC2 ANAPC10 | Cell Cycle |
| REAC:R-HSA-2467813 | 2.90043910375e-18 | 0.65 | ANAPC15 BUB1B CDC26 ANAPC16 ANAPC5 ANAPC4 ANAPC1 CDC23 CDC16 CDC20 ANAPC7 ANAPC2 ANAPC10 | Separation of Sister Chromatids |
| REAC:R-HSA-68867 | 5.38022934441e-18 | 0.6 | ANAPC15 ANAPC10 CDC26 ANAPC16 FZR1 ANAPC4 CDC23 CDC16 ANAPC5 ANAPC1 ANAPC2 ANAPC7 | Assembly of the pre-replicative complex |
| REAC:R-HSA-68886 | 7.2038309287e-18 | 0.75 | ANAPC15 FBXO5 BUB1B CDC26 NEK2 ANAPC16 ANAPC5 ANAPC4 ANAPC1 CDC23 CDC16 CDC20 ANAPC7 ANAPC2 ANAPC10 | M Phase |
| GO:0000151 | 7.53840549039e-18 | 0.75 | ANAPC15 BUB1B CDC26 ANAPC10 ANAPC16 ANAPC5 FZR1 ANAPC4 CDC23 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 ANAPC13 | ubiquitin ligase complex |
| GO:0000278 | 2.22355518893e-17 | 0.9 | ANAPC15 CDC16 FBXO5 BUB1B CDC26 NEK2 ANAPC10 ANAPC16 ANAPC5 FZR1 ANAPC4 CDC23 CDC20 RRM2 ANAPC7 ANAPC1 ANAPC2 ANAPC13 | mitotic cell cycle |
| REAC:R-HSA-69002 | 2.48047963211e-17 | 0.6 | ANAPC15 ANAPC10 CDC26 ANAPC16 FZR1 ANAPC4 CDC23 CDC16 ANAPC5 ANAPC1 ANAPC2 ANAPC7 | DNA Replication Pre-Initiation |
| REAC:R-HSA-68882 | 3.74764076077e-17 | 0.65 | ANAPC15 BUB1B CDC26 ANAPC16 ANAPC5 ANAPC4 ANAPC1 CDC23 CDC16 CDC20 ANAPC7 ANAPC2 ANAPC10 | Mitotic Anaphase |
| REAC:R-HSA-69242 | 6.55139011884e-17 | 0.6 | ANAPC15 ANAPC10 CDC26 ANAPC16 FZR1 ANAPC4 CDC23 CDC16 ANAPC5 ANAPC1 ANAPC2 ANAPC7 | S Phase |
| WP:WP179 | 9.46964529991e-17 | 0.55 | ANAPC10 CDC16 ANAPC5 FZR1 ANAPC4 ANAPC13 ANAPC2 CDC20 ANAPC7 ANAPC1 CDC23 | Cell cycle |
| GO:0019953 | 1.01097144161e-16 | 0.8 | CFAP97 ANAPC15 FBXO5 ANAPC10 CDC26 ANAPC16 ANAPC5 FZR1 ANAPC4 ANAPC13 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 CDC23 | sexual reproduction |
| REAC:R-HSA-69306 | 1.99126934038e-16 | 0.6 | ANAPC15 ANAPC10 CDC26 ANAPC16 FZR1 ANAPC4 CDC23 CDC16 ANAPC5 ANAPC1 ANAPC2 ANAPC7 | DNA Replication |
| GO:0051726 | 2.07647566591e-16 | 0.9 | ANAPC15 CDC16 FBXO5 BUB1B CDC26 NEK2 ANAPC10 ANAPC16 ANAPC5 FZR1 ANAPC4 CDC23 CDC20 RRM2 ANAPC7 ANAPC1 ANAPC2 ANAPC13 | regulation of cell cycle |
| REAC:R-HSA-2559583 | 2.13677404815e-16 | 0.6 | ANAPC15 ANAPC10 CDC26 ANAPC16 FZR1 ANAPC4 CDC23 CDC16 ANAPC5 ANAPC1 ANAPC2 ANAPC7 | Cellular Senescence |
| REAC:R-HSA-69620 | 7.23128733135e-16 | 0.65 | ANAPC15 BUB1B CDC26 ANAPC16 ANAPC5 ANAPC4 ANAPC1 CDC23 CDC16 CDC20 ANAPC7 ANAPC2 ANAPC10 | Cell Cycle Checkpoints |
| GO:0022414 | 1.05664552779e-14 | 0.8 | CFAP97 ANAPC15 FBXO5 ANAPC10 CDC26 ANAPC16 ANAPC5 FZR1 ANAPC4 ANAPC13 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 CDC23 | reproductive process |
| GO:0000003 | 1.17592093774e-14 | 0.8 | CFAP97 ANAPC15 FBXO5 ANAPC10 CDC26 ANAPC16 ANAPC5 FZR1 ANAPC4 ANAPC13 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 CDC23 | reproduction |
| GO:0043161 | 1.32768831935e-14 | 0.7 | ANAPC15 ANAPC10 CDC26 ANAPC16 ANAPC5 FZR1 ANAPC4 ANAPC13 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 CDC23 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| REAC:R-HSA-983168 | 7.19319931636e-14 | 0.6 | ANAPC10 CDC16 ANAPC5 FZR1 ANAPC4 ANAPC13 CDC26 CDC20 ANAPC7 ANAPC1 ANAPC2 CDC23 | Antigen processing: Ubiquitination & Proteasome degradation |
| GO:0007091 | 2.5538660475e-13 | 0.5 | ANAPC15 BUB1B CDC16 ANAPC1 FBXO5 ANAPC7 ANAPC2 CDC20 ANAPC5 CDC23 | metaphase/anaphase transition of mitotic cell cycle |
| GO:0044784 | 3.25140819884e-13 | 0.5 | ANAPC15 BUB1B CDC16 ANAPC1 FBXO5 ANAPC7 ANAPC2 CDC20 ANAPC5 CDC23 | metaphase/anaphase transition of cell cycle |
| GO:0010498 | 3.8741636786e-13 | 0.7 | ANAPC15 ANAPC10 CDC26 ANAPC16 ANAPC5 FZR1 ANAPC4 ANAPC13 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 CDC23 | proteasomal protein catabolic process |
| GO:0007049 | 4.69687686711e-13 | 0.9 | ANAPC15 CDC16 FBXO5 BUB1B CDC26 NEK2 ANAPC10 ANAPC16 ANAPC5 FZR1 ANAPC4 CDC23 CDC20 RRM2 ANAPC7 ANAPC1 ANAPC2 ANAPC13 | cell cycle |
| GO:0033045 | 7.24725662443e-13 | 0.5 | ANAPC15 BUB1B CDC16 ANAPC1 FBXO5 ANAPC7 ANAPC2 CDC20 ANAPC5 CDC23 | regulation of sister chromatid segregation |
| REAC:R-HSA-983169 | 8.46844641956e-13 | 0.6 | ANAPC10 CDC16 ANAPC5 FZR1 ANAPC4 ANAPC13 CDC26 CDC20 ANAPC7 ANAPC1 ANAPC2 CDC23 | Class I MHC mediated antigen processing & presentation |
| GO:0006511 | 3.13403915641e-12 | 0.7 | ANAPC15 ANAPC10 CDC26 ANAPC16 ANAPC5 FZR1 ANAPC4 ANAPC13 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 CDC23 | ubiquitin-dependent protein catabolic process |
| GO:0019941 | 3.92926685226e-12 | 0.7 | ANAPC15 ANAPC10 CDC26 ANAPC16 ANAPC5 FZR1 ANAPC4 ANAPC13 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 CDC23 | modification-dependent protein catabolic process |
| GO:0043632 | 5.33009868309e-12 | 0.7 | ANAPC15 ANAPC10 CDC26 ANAPC16 ANAPC5 FZR1 ANAPC4 ANAPC13 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 CDC23 | modification-dependent macromolecule catabolic process |
| GO:0016567 | 6.44888534664e-12 | 0.7 | CDC26 FBXO5 ANAPC10 ANAPC16 ANAPC5 FZR1 ANAPC4 ANAPC13 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 CDC23 | protein ubiquitination |
| GO:0051983 | 7.51689778788e-12 | 0.5 | ANAPC15 BUB1B CDC16 ANAPC1 FBXO5 ANAPC7 ANAPC2 CDC20 ANAPC5 CDC23 | regulation of chromosome segregation |
| GO:0032446 | 3.88189686545e-11 | 0.7 | CDC26 FBXO5 ANAPC10 ANAPC16 ANAPC5 FZR1 ANAPC4 ANAPC13 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 CDC23 | protein modification by small protein conjugation |
| GO:1990234 | 4.06354275303e-11 | 0.75 | ANAPC15 BUB1B CDC26 ANAPC10 ANAPC16 ANAPC5 FZR1 ANAPC4 CDC23 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 ANAPC13 | transferase complex |
| GO:0000209 | 4.48046425616e-11 | 0.55 | ANAPC10 CDC16 ANAPC5 FZR1 ANAPC4 ANAPC13 CDC26 ANAPC7 ANAPC1 ANAPC2 CDC23 | protein polyubiquitination |
| GO:0051603 | 5.64053588963e-11 | 0.7 | ANAPC15 ANAPC10 CDC26 ANAPC16 ANAPC5 FZR1 ANAPC4 ANAPC13 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 CDC23 | proteolysis involved in protein catabolic process |
| GO:0010965 | 8.90743665161e-11 | 0.4 | ANAPC15 BUB1B CDC16 FBXO5 ANAPC7 CDC20 ANAPC5 CDC23 | regulation of mitotic sister chromatid separation |
| GO:0033044 | 8.98267572601e-11 | 0.55 | NEK2 BUB1B ANAPC15 CDC16 ANAPC1 FBXO5 CDC23 ANAPC2 CDC20 ANAPC5 ANAPC7 | regulation of chromosome organization |
| GO:0140535 | 9.55340383069e-11 | 0.75 | ANAPC15 BUB1B CDC26 ANAPC10 ANAPC16 ANAPC5 FZR1 ANAPC4 CDC23 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 ANAPC13 | intracellular protein-containing complex |
| GO:0044772 | 1.02921030144e-10 | 0.6 | ANAPC15 FBXO5 BUB1B CDC16 FZR1 ANAPC1 CDC23 CDC20 RRM2 ANAPC5 ANAPC2 ANAPC7 | mitotic cell cycle phase transition |
| GO:0007088 | 1.1129372073e-10 | 0.45 | NEK2 BUB1B ANAPC15 CDC16 FBXO5 CDC23 CDC20 ANAPC5 ANAPC7 | regulation of mitotic nuclear division |
| GO:0051306 | 1.22974772768e-10 | 0.4 | ANAPC15 BUB1B CDC16 FBXO5 ANAPC7 CDC20 ANAPC5 CDC23 | mitotic sister chromatid separation |
| GO:0098813 | 1.50574415833e-10 | 0.55 | NEK2 BUB1B ANAPC15 CDC16 ANAPC1 FBXO5 CDC23 ANAPC2 CDC20 ANAPC5 ANAPC7 | nuclear chromosome segregation |
| GO:0070647 | 1.53121925995e-10 | 0.7 | CDC26 FBXO5 ANAPC10 ANAPC16 ANAPC5 FZR1 ANAPC4 ANAPC13 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 CDC23 | protein modification by small protein conjugation or removal |
| GO:0051783 | 2.15912789914e-10 | 0.45 | NEK2 BUB1B ANAPC15 CDC16 FBXO5 CDC23 CDC20 ANAPC5 ANAPC7 | regulation of nuclear division |
| GO:0043687 | 3.8032277302e-10 | 0.7 | CDC26 FBXO5 ANAPC10 ANAPC16 ANAPC5 FZR1 ANAPC4 ANAPC13 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 CDC23 | post-translational protein modification |
| GO:1905818 | 6.72903694571e-10 | 0.4 | ANAPC15 BUB1B CDC16 FBXO5 ANAPC7 CDC20 ANAPC5 CDC23 | regulation of chromosome separation |
| GO:0010564 | 8.62641279285e-10 | 0.65 | ANAPC15 FBXO5 BUB1B NEK2 CDC16 FZR1 ANAPC1 CDC23 CDC20 RRM2 ANAPC5 ANAPC2 ANAPC7 | regulation of cell cycle process |
| GO:0051304 | 1.3961101895e-09 | 0.4 | ANAPC15 BUB1B CDC16 FBXO5 ANAPC7 CDC20 ANAPC5 CDC23 | chromosome separation |
| GO:0044770 | 1.42991630967e-09 | 0.6 | ANAPC15 FBXO5 BUB1B CDC16 FZR1 ANAPC1 CDC23 CDC20 RRM2 ANAPC5 ANAPC2 ANAPC7 | cell cycle phase transition |
| GO:0030163 | 1.49288647122e-09 | 0.7 | ANAPC15 ANAPC10 CDC26 ANAPC16 ANAPC5 FZR1 ANAPC4 ANAPC13 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 CDC23 | protein catabolic process |
| GO:0000819 | 1.50749924068e-09 | 0.5 | ANAPC15 BUB1B CDC16 ANAPC1 FBXO5 ANAPC7 ANAPC2 CDC20 ANAPC5 CDC23 | sister chromatid segregation |
| REAC:R-HSA-1280218 | 1.96454043304e-09 | 0.6 | ANAPC10 CDC16 ANAPC5 FZR1 ANAPC4 ANAPC13 CDC26 CDC20 ANAPC7 ANAPC1 ANAPC2 CDC23 | Adaptive Immune System |
| GO:1903047 | 2.36147421438e-09 | 0.65 | ANAPC15 FBXO5 BUB1B NEK2 CDC16 FZR1 ANAPC1 CDC23 CDC20 RRM2 ANAPC5 ANAPC2 ANAPC7 | mitotic cell cycle process |
| GO:0007059 | 3.64925924414e-09 | 0.55 | NEK2 BUB1B ANAPC15 CDC16 ANAPC1 FBXO5 CDC23 ANAPC2 CDC20 ANAPC5 ANAPC7 | chromosome segregation |
| GO:0030071 | 4.1269845781e-09 | 0.4 | ANAPC15 BUB1B CDC16 FBXO5 ANAPC7 CDC20 ANAPC5 CDC23 | regulation of mitotic metaphase/anaphase transition |
| GO:1902099 | 5.04055511564e-09 | 0.4 | ANAPC15 BUB1B CDC16 FBXO5 ANAPC7 CDC20 ANAPC5 CDC23 | regulation of metaphase/anaphase transition of cell cycle |
| REAC:R-HSA-2262752 | 5.33272012943e-09 | 0.6 | ANAPC15 ANAPC10 CDC26 ANAPC16 FZR1 ANAPC4 CDC23 CDC16 ANAPC5 ANAPC1 ANAPC2 ANAPC7 | Cellular responses to stress |
| REAC:R-HSA-8953897 | 5.96953804965e-09 | 0.6 | ANAPC15 ANAPC10 CDC26 ANAPC16 FZR1 ANAPC4 CDC23 CDC16 ANAPC5 ANAPC1 ANAPC2 ANAPC7 | Cellular responses to stimuli |
| GO:0140513 | 7.54794878689e-09 | 0.75 | ANAPC15 BUB1B CDC26 ANAPC10 ANAPC16 ANAPC5 FZR1 ANAPC4 CDC23 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 ANAPC13 | nuclear protein-containing complex |
| REAC:R-HSA-212436 | 1.3985552436e-08 | 0.65 | ANAPC15 ANAPC10 CDC26 CDC16 FZR1 ANAPC4 CDC23 ANAPC16 RRM2 ANAPC5 ANAPC1 ANAPC2 ANAPC7 | Generic Transcription Pathway |
| GO:1901990 | 2.27918542378e-08 | 0.5 | ANAPC15 BUB1B CDC16 FZR1 FBXO5 CDC23 CDC20 RRM2 ANAPC5 ANAPC7 | regulation of mitotic cell cycle phase transition |
| GO:1902494 | 3.05297361037e-08 | 0.8 | ANAPC15 CDC16 BUB1B CDC26 ANAPC10 ANAPC16 ANAPC5 FZR1 ANAPC4 CDC23 CDC20 RRM2 ANAPC7 ANAPC1 ANAPC2 ANAPC13 | catalytic complex |
| REAC:R-HSA-73857 | 5.55443921635e-08 | 0.65 | ANAPC15 ANAPC10 CDC26 CDC16 FZR1 ANAPC4 CDC23 ANAPC16 RRM2 ANAPC5 ANAPC1 ANAPC2 ANAPC7 | RNA Polymerase II Transcription |
| GO:1901992 | 1.02159414485e-07 | 0.35 | ANAPC5 CDC16 FBXO5 CDC23 CDC20 RRM2 ANAPC7 | positive regulation of mitotic cell cycle phase transition |
| GO:0009057 | 1.14195239604e-07 | 0.7 | ANAPC15 ANAPC10 CDC26 ANAPC16 ANAPC5 FZR1 ANAPC4 ANAPC13 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 CDC23 | macromolecule catabolic process |
| GO:0006508 | 1.23444843152e-07 | 0.7 | ANAPC15 ANAPC10 CDC26 ANAPC16 ANAPC5 FZR1 ANAPC4 ANAPC13 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 CDC23 | proteolysis |
| GO:1901565 | 1.26678665957e-07 | 0.7 | ANAPC15 ANAPC10 CDC26 ANAPC16 ANAPC5 FZR1 ANAPC4 ANAPC13 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 CDC23 | organonitrogen compound catabolic process |
| REAC:R-HSA-74160 | 2.66001588842e-07 | 0.65 | ANAPC15 ANAPC10 CDC26 CDC16 FZR1 ANAPC4 CDC23 ANAPC16 RRM2 ANAPC5 ANAPC1 ANAPC2 ANAPC7 | Gene expression (Transcription) |
| GO:0045842 | 2.77342308517e-07 | 0.25 | CDC20 ANAPC7 ANAPC5 CDC23 CDC16 | positive regulation of mitotic metaphase/anaphase transition |
| GO:1902101 | 2.77342308517e-07 | 0.25 | CDC20 ANAPC7 ANAPC5 CDC23 CDC16 | positive regulation of metaphase/anaphase transition of cell cycle |
| GO:0140014 | 3.12381230788e-07 | 0.45 | NEK2 BUB1B ANAPC15 CDC16 FBXO5 CDC23 CDC20 ANAPC5 ANAPC7 | mitotic nuclear division |
| GO:1901987 | 3.14951921297e-07 | 0.5 | ANAPC15 BUB1B CDC16 FZR1 FBXO5 CDC23 CDC20 RRM2 ANAPC5 ANAPC7 | regulation of cell cycle phase transition |
| GO:0051276 | 4.47271104095e-07 | 0.55 | NEK2 BUB1B ANAPC15 CDC16 ANAPC1 FBXO5 CDC23 ANAPC2 CDC20 ANAPC5 ANAPC7 | chromosome organization |
| GO:1901989 | 5.37448932388e-07 | 0.35 | ANAPC5 CDC16 FBXO5 CDC23 CDC20 RRM2 ANAPC7 | positive regulation of cell cycle phase transition |
| GO:0045931 | 9.61859606772e-07 | 0.35 | ANAPC5 CDC16 FBXO5 CDC23 CDC20 RRM2 ANAPC7 | positive regulation of mitotic cell cycle |
| GO:0000070 | 1.025229093e-06 | 0.4 | ANAPC15 BUB1B CDC16 FBXO5 ANAPC7 CDC20 ANAPC5 CDC23 | mitotic sister chromatid segregation |
| GO:1901970 | 1.18288915211e-06 | 0.25 | CDC20 ANAPC7 ANAPC5 CDC23 CDC16 | positive regulation of mitotic sister chromatid separation |
| GO:0022402 | 1.27870011081e-06 | 0.65 | ANAPC15 FBXO5 BUB1B NEK2 CDC16 FZR1 ANAPC1 CDC23 CDC20 RRM2 ANAPC5 ANAPC2 ANAPC7 | cell cycle process |
| GO:0000280 | 6.10788073992e-06 | 0.45 | NEK2 BUB1B ANAPC15 CDC16 FBXO5 CDC23 CDC20 ANAPC5 ANAPC7 | nuclear division |
| GO:1905820 | 1.34527228796e-05 | 0.25 | CDC20 ANAPC7 ANAPC5 CDC23 CDC16 | positive regulation of chromosome separation |
| REAC:R-HSA-176417 | 1.35764294999e-05 | 0.15 | CDC20 FZR1 FBXO5 | Phosphorylation of Emi1 |
| GO:1901575 | 1.47809042306e-05 | 0.7 | ANAPC15 ANAPC10 CDC26 ANAPC16 ANAPC5 FZR1 ANAPC4 ANAPC13 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 CDC23 | organic substance catabolic process |
| GO:0048285 | 1.72184442815e-05 | 0.45 | NEK2 BUB1B ANAPC15 CDC16 FBXO5 CDC23 CDC20 ANAPC5 ANAPC7 | organelle fission |
| REAC:R-HSA-1643685 | 2.08589176439e-05 | 0.6 | ANAPC15 ANAPC10 CDC26 ANAPC16 FZR1 ANAPC4 CDC23 CDC16 ANAPC5 ANAPC1 ANAPC2 ANAPC7 | Disease |
| GO:0045840 | 2.7470374868e-05 | 0.25 | CDC20 ANAPC7 ANAPC5 CDC23 CDC16 | positive regulation of mitotic nuclear division |
| GO:0051785 | 5.92079814967e-05 | 0.25 | CDC20 ANAPC7 ANAPC5 CDC23 CDC16 | positive regulation of nuclear division |
| CORUM:5361 | 6.49329465809e-05 | 0.1 | CDC16 ANAPC7 | Cell division cycle complex (CDC27, CDC16, ANAPC7) |
| GO:0036211 | 6.54764794815e-05 | 0.75 | NEK2 FBXO5 ANAPC10 CDC26 ANAPC16 ANAPC5 FZR1 ANAPC4 ANAPC13 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 CDC23 | protein modification process |
| REAC:R-HSA-168256 | 8.65491612925e-05 | 0.6 | ANAPC10 CDC16 ANAPC5 FZR1 ANAPC4 ANAPC13 CDC26 CDC20 ANAPC7 ANAPC1 ANAPC2 CDC23 | Immune System |
| GO:0090068 | 0.000162769449167 | 0.35 | ANAPC5 CDC16 FBXO5 CDC23 CDC20 RRM2 ANAPC7 | positive regulation of cell cycle process |
| GO:0043412 | 0.000211369168771 | 0.75 | NEK2 FBXO5 ANAPC10 CDC26 ANAPC16 ANAPC5 FZR1 ANAPC4 ANAPC13 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 CDC23 | macromolecule modification |
| GO:0033043 | 0.000223244473066 | 0.55 | NEK2 BUB1B ANAPC15 CDC16 ANAPC1 FBXO5 CDC23 ANAPC2 CDC20 ANAPC5 ANAPC7 | regulation of organelle organization |
| GO:0009056 | 0.000280600752506 | 0.7 | ANAPC15 ANAPC10 CDC26 ANAPC16 ANAPC5 FZR1 ANAPC4 ANAPC13 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 CDC23 | catabolic process |
| CORUM:190 | 0.00038895809385 | 0.1 | CDC20 BUB1B | Mitotic checkpoint complex (MCC) |
| GO:0019538 | 0.000558463734655 | 0.85 | GNPTAB FBXO5 ANAPC10 CDC26 ANAPC15 ANAPC16 ANAPC5 FZR1 NEK2 ANAPC4 CDC23 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 ANAPC13 | protein metabolic process |
| GO:0045787 | 0.00103870458033 | 0.35 | ANAPC5 CDC16 FBXO5 CDC23 CDC20 RRM2 ANAPC7 | positive regulation of cell cycle |
| HPA:0310431 | 0.00159473781794 | 0.8 | ANAPC15 CDC16 FBXO5 ANAPC10 CDC26 GNPTAB ANAPC16 ANAPC4 NEK2 CDC23 CDC20 RRM2 ANAPC5 ANAPC1 ANAPC2 ANAPC7 | lymph node; germinal center cells[>=Low] |
| GO:0010997 | 0.00915637133828 | 0.15 | CDC20 FZR1 FBXO5 | anaphase-promoting complex binding |
| GO:0033046 | 0.0138017804915 | 0.2 | CDC20 FBXO5 BUB1B ANAPC15 | negative regulation of sister chromatid segregation |
| GO:0045841 | 0.0138017804915 | 0.2 | CDC20 FBXO5 BUB1B ANAPC15 | negative regulation of mitotic metaphase/anaphase transition |
| GO:0033048 | 0.0138017804915 | 0.2 | CDC20 FBXO5 BUB1B ANAPC15 | negative regulation of mitotic sister chromatid segregation |
| GO:2000816 | 0.0138017804915 | 0.2 | CDC20 FBXO5 BUB1B ANAPC15 | negative regulation of mitotic sister chromatid separation |
| GO:1901564 | 0.0140266706393 | 0.85 | GNPTAB FBXO5 ANAPC10 CDC26 ANAPC15 ANAPC16 ANAPC5 FZR1 NEK2 ANAPC4 CDC23 CDC16 CDC20 ANAPC7 ANAPC1 ANAPC2 ANAPC13 | organonitrogen compound metabolic process |
| REAC:R-HSA-174113 | 0.0161466146549 | 0.15 | CDC20 FZR1 FBXO5 | SCF-beta-TrCP mediated degradation of Emi1 |
| GO:1905819 | 0.0167097438311 | 0.2 | CDC20 FBXO5 BUB1B ANAPC15 | negative regulation of chromosome separation |
| GO:1902100 | 0.0167097438311 | 0.2 | CDC20 FBXO5 BUB1B ANAPC15 | negative regulation of metaphase/anaphase transition of cell cycle |
| GO:0051985 | 0.0167097438311 | 0.2 | CDC20 FBXO5 BUB1B ANAPC15 | negative regulation of chromosome segregation |
| WP:WP4240 | 0.0197920993247 | 0.1 | CDC20 BUB1B | Regulation of sister chromatid separation at the metaphase anaphase transition |
| GO:0033047 | 0.0238671820955 | 0.2 | CDC20 FBXO5 BUB1B ANAPC15 | regulation of mitotic sister chromatid segregation |
| GO:0045839 | 0.025965921633 | 0.2 | CDC20 FBXO5 BUB1B ANAPC15 | negative regulation of mitotic nuclear division |
| GO:0010948 | 0.0273495495134 | 0.3 | ANAPC15 BUB1B NEK2 FBXO5 FZR1 CDC20 | negative regulation of cell cycle process |
| GO:0051784 | 0.0330908087031 | 0.2 | CDC20 FBXO5 BUB1B ANAPC15 | negative regulation of nuclear division |
| GO:0005829 | 0.0370667451336 | 0.85 | ANAPC15 CDC16 FBXO5 BUB1B CDC26 NEK2 ANAPC16 ANAPC5 FZR1 ANAPC4 CDC23 CDC20 RRM2 ANAPC7 ANAPC1 ANAPC2 ANAPC10 | cytosol |
| HPA:0310000 | 0.0455931704824 | 0.8 | ANAPC15 CDC16 FBXO5 ANAPC10 CDC26 GNPTAB ANAPC16 ANAPC4 NEK2 CDC23 CDC20 RRM2 ANAPC5 ANAPC1 ANAPC2 ANAPC7 | lymph node |
| CORUM:1932 | 0.0499436884912 | 0.05 | NEK2 | NEK2-NEK11 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
| ANAPC4 | ANAPC5 | 1.0 | 0.468 |
structurally_consistent (dimer)
|
| ANAPC1 | ANAPC5 | 1.0 | 0.79 |
structurally_consistent (dimer)
|
| CDC16 | ANAPC1 | 1.0 | 0.498 | |
| CDC16 | ANAPC4 | 1.0 | 0.276 | |
| ANAPC16 | ANAPC4 | 1.0 | 0.15 | |
| CDC23 | CDC16 | 1.0 | 0.752 | |
| ANAPC5 | ANAPC2 | 1.0 | 0.436 | |
| ANAPC16 | ANAPC1 | 1.0 | 0.194 | |
| CDC16 | ANAPC5 | 1.0 | 0.408 | |
| ANAPC4 | ANAPC2 | 1.0 | 0.418 |
structurally_consistent (dimer)
|
| ANAPC16 | CDC23 | 1.0 | 0.244 | |
| ANAPC16 | ANAPC7 | 1.0 | 0.534 | |
| CDC16 | ANAPC2 | 1.0 | 0.348 | |
| CDC26 | ANAPC1 | 1.0 | 0.218 | |
| ANAPC16 | CDC27 | 1.0 | 0.296 |
structurally_consistent (dimer)
|
| ANAPC16 | ANAPC2 | 1.0 | 0.29 | |
| CDC26 | ANAPC4 | 1.0 | 0.062 | |
| CDC26 | ANAPC2 | 1.0 | 0.194 | |
| ANAPC16 | ANAPC5 | 1.0 | 0.336 | |
| CDC16 | CDC27 | 1.0 | 0.124 |
structurally_consistent (dimer)
|
| CDC16 | ANAPC10 | 1.0 | 0.21 |
structurally_consistent (P30260)
structurally_consistent (dimer) |
| CDC23 | ANAPC4 | 1.0 | 0.586 |
structurally_consistent (Q9UJX4)
|
| ANAPC10 | ANAPC4 | 1.0 | 0.232 | |
| CDC23 | CDC27 | 1.0 | 0.188 | |
| CDC26 | ANAPC7 | 1.0 | 0.106 | |
| ANAPC13 | ANAPC2 | 1.0 | 0.088 | |
| CDC23 | ANAPC5 | 1.0 | 0.628 |
structurally_consistent (dimer)
|
| CDC26 | ANAPC5 | 1.0 | 0.15 | |
| ANAPC7 | ANAPC5 | 1.0 | 0.436 | |
| ANAPC16 | CDC16 | 1.0 | 0.18 |
structurally_consistent (P30260)
|
| ANAPC4 | CDC27 | 1.0 | 0.186 |
structurally_consistent (Q9UJX6)
|
| FZR1 | CDC16 | 1.0 | 0.132 | |
| ANAPC4 | ANAPC1 | 1.0 | 0.402 |
structurally_consistent (Q9UJX6)
|
| ANAPC1 | CDC27 | 1.0 | 0.354 |
structurally_consistent (Q9UJX6)
|
| ANAPC13 | CDC26 | 1.0 | 0.132 | |
| ANAPC13 | CDC16 | 1.0 | 0.086 | |
| CDC23 | ANAPC10 | 1.0 | 0.262 |
structurally_consistent (dimer)
|
| ANAPC10 | ANAPC2 | 1.0 | 0.236 |
structurally_consistent (Q9H1A4)
|
| ANAPC16 | CDC26 | 1.0 | 0.198 | |
| ANAPC13 | CDC27 | 1.0 | 0.122 | |
| ANAPC13 | ANAPC4 | 1.0 | 0.19 | |
| CDC23 | ANAPC2 | 1.0 | 0.226 | |
| ANAPC16 | ANAPC13 | 1.0 | 0.168 | |
| CDC27 | ANAPC2 | 1.0 | 0.088 |
structurally_consistent (dimer)
|
| ANAPC7 | ANAPC2 | 1.0 | 0.19 | |
| ANAPC1 | ANAPC2 | 1.0 | 0.448 |
structurally_consistent (dimer)
|
| CDC26 | CDC27 | 1.0 | 0.166 |
structurally_consistent (Q9UM11)
|
| ANAPC10 | ANAPC5 | 1.0 | 0.208 |
structurally_consistent (Q9H1A4)
|
| CDC16 | CDC26 | 1.0 | 0.186 | |
| ANAPC16 | ANAPC10 | 1.0 | 0.354 | |
| FZR1 | CDC26 | 1.0 | 0.1 |
structurally_consistent (dimer)
|
| ANAPC10 | CDC26 | 1.0 | 0.208 |
mutually_exclusive (O43684)
|
| ANAPC13 | ANAPC10 | 1.0 | 0.176 | |
| ANAPC7 | ANAPC4 | 1.0 | 0.3 | |
| FZR1 | CDC23 | 1.0 | 0.138 | |
| CDC23 | CDC26 | 1.0 | 0.112 | |
| CDC27 | ANAPC5 | 1.0 | 0.486 | |
| ANAPC13 | ANAPC1 | 1.0 | 0.17 | |
| ANAPC13 | ANAPC7 | 1.0 | 0.136 | |
| ANAPC10 | CDC27 | 1.0 | 0.172 |
structurally_consistent (Q9UM11)
structurally_consistent (dimer) |
| ANAPC7 | ANAPC1 | 1.0 | 0.416 | |
| ANAPC13 | ANAPC5 | 1.0 | 0.132 | |
| CDC23 | ANAPC13 | 1.0 | 0.166 | |
| CDC26 | FBXO5 | 1.0 | 0.156 | |
| FZR1 | CDC27 | 1.0 | 0.08 |
structurally_consistent (dimer)
|
| FZR1 | ANAPC2 | 1.0 | 0.07 | |
| ANAPC2 | FBXO5 | 0.999 | 0.052 | |
| FZR1 | ANAPC16 | 0.999 | 0.128 |
structurally_consistent (dimer)
|
| ANAPC7 | FBXO5 | 0.999 | 0.212 | |
| ANAPC10 | FBXO5 | 0.999 | 0.15 | |
| CDC23 | ANAPC1 | 0.999 | 0.528 |
structurally_consistent (Q9UM13)
|
| ANAPC10 | ANAPC7 | 0.999 | 0.274 | |
| FZR1 | ANAPC5 | 0.999 | 0.08 | |
| CDC16 | FBXO5 | 0.999 | 0.132 | |
| ANAPC16 | FBXO5 | 0.999 | 0.082 | |
| CDC23 | FBXO5 | 0.999 | 0.174 | |
| FZR1 | ANAPC4 | 0.999 | 0.134 | |
| CDC27 | FBXO5 | 0.999 | 0.174 | |
| CDC23 | ANAPC7 | 0.999 | 0.548 | |
| ANAPC7 | CDC27 | 0.999 | 0.622 | |
| CDC16 | ANAPC7 | 0.999 | 0.188 | |
| FZR1 | ANAPC1 | 0.999 | 0.19 | |
| ANAPC10 | ANAPC1 | 0.999 | 0.282 |
structurally_consistent (dimer)
|
| NEK2 | ANAPC2 | 0.999 | 0.16 | |
| FZR1 | ANAPC7 | 0.999 | 0.124 | |
| ANAPC5 | FBXO5 | 0.999 | 0.114 | |
| FZR1 | FBXO5 | 0.999 | 0.12 | |
| ANAPC1 | FBXO5 | 0.999 | 0.121333333333 | |
| FZR1 | ANAPC10 | 0.999 | 0.16 |
mutually_exclusive (O43684)
structurally_consistent (dimer) |
| CDC20 | CDC26 | 0.999 | 0.228206185567 | |
| FZR1 | RRM2 | 0.998 | 0.092 |
structurally_consistent (dimer)
|
| BUB1B | ANAPC2 | 0.998 | 0.116 | |
| CDC20 | ANAPC5 | 0.998 | 0.098 | |
| FZR1 | ANAPC13 | 0.998 | 0.076 | |
| CDC20 | FBXO5 | 0.998 | 0.15637037037 | |
| ANAPC4 | FBXO5 | 0.998 | 0.168 | |
| BUB1B | CDC20 | 0.998 | 0.212 |
structurally_consistent (dimer)
|
| RRM2 | ANAPC2 | 0.997 | 0.042 | |
| CDC20 | ANAPC2 | 0.997 | 0.108 | |
| CDC20 | CDC16 | 0.997 | 0.068 |
structurally_consistent (Q9UM13)
|
| ANAPC16 | NEK2 | 0.997 | 0.222 | |
| GNPTAB | ANAPC2 | 0.996 | 0.192 | |
| CDC20 | ANAPC13 | 0.996 | 0.162 | |
| ANAPC13 | FBXO5 | 0.996 | 0.102 | |
| RRM2 | CDC26 | 0.996 | 0.088 | |
| ANAPC16 | CDC20 | 0.995 | 0.246 | |
| RRM2 | FBXO5 | 0.994 | 0.178 | |
| BUB1B | CDC26 | 0.994 | 0.158 |
mutually_exclusive (O43684)
|
| ANAPC16 | CFAP97 | 0.994 | 0.122 | |
| CDC20 | CDC23 | 0.994 | 0.0904666666667 |
structurally_consistent (Q9UM13)
structurally_consistent (dimer) |
| GNPTAB | ANAPC13 | 0.993 | 0.084 | |
| CFAP97 | ANAPC2 | 0.993 | 0.148 | |
| NEK2 | ANAPC5 | 0.993 | 0.128 | |
| GNPTAB | CDC26 | 0.993 | 0.086 | |
| ANAPC15 | ANAPC5 | 0.993 | 0.378 | |
| ANAPC15 | ANAPC2 | 0.993 | 0.29 | |
| CDC26 | CFAP97 | 0.992 | 0.11 | |
| CDC20 | ANAPC1 | 0.992 | 0.206339622642 |
structurally_consistent (Q9UM13)
|
| NEK2 | CDC26 | 0.992 | 0.17 | |
| GNPTAB | ANAPC16 | 0.991 | 0.178 | |
| NEK2 | ANAPC7 | 0.991 | 0.174 | |
| RRM2 | CDC27 | 0.991 | 0.182 | |
| CDC27 | CFAP97 | 0.991 | 0.054 | |
| GNPTAB | CDC23 | 0.991 | 0.11 | |
| ANAPC1 | CFAP97 | 0.99 | 0.14 | |
| CDC23 | CFAP97 | 0.988 | 0.062 | |
| ANAPC16 | ANAPC15 | 0.988 | 0.144222222222 | |
| BUB1B | CDC23 | 0.988 | 0.114219858156 |
structurally_consistent (Q12834)
|
| ANAPC15 | CDC23 | 0.988 | 0.248 | |
| ANAPC15 | CDC16 | 0.988 | 0.398 | |
| RRM2 | CDC16 | 0.987 | 0.062 | |
| ANAPC15 | CDC27 | 0.987 | 0.232 | |
| ANAPC15 | ANAPC4 | 0.987 | 0.574 | |
| GNPTAB | ANAPC7 | 0.986 | 0.074 | |
| ANAPC15 | ANAPC7 | 0.986 | 0.252115384615 | |
| FZR1 | NEK2 | 0.986 | 0.192 | |
| ANAPC13 | CFAP97 | 0.985 | 0.068 | |
| FZR1 | CDC20 | 0.985 | 0.138560283688 | |
| CDC16 | CFAP97 | 0.985 | 0.064 | |
| GNPTAB | CDC16 | 0.984 | 0.068 | |
| GNPTAB | ANAPC5 | 0.984 | 0.11 | |
| RRM2 | CDC23 | 0.984 | 0.026 | |
| RRM2 | ANAPC16 | 0.984 | 0.108 |
mutually_exclusive (Q9UM11)
|
| ANAPC15 | ANAPC1 | 0.982 | 0.464 | |
| CFAP97 | FBXO5 | 0.982 | 0.182 | |
| FZR1 | CFAP97 | 0.981 | 0.114 | |
| ANAPC13 | NEK2 | 0.981 | 0.178 | |
| GNPTAB | FBXO5 | 0.981 | 0.086 | |
| NEK2 | ANAPC10 | 0.98 | 0.182 | |
| ANAPC15 | CDC26 | 0.979 | 0.172 |
mutually_exclusive (O43684)
|
| NEK2 | ANAPC1 | 0.979 | 0.19 | |
| RRM2 | ANAPC13 | 0.979 | 0.056 | |
| NEK2 | CFAP97 | 0.979 | 0.18 | |
| CDC20 | CDC27 | 0.978 | 0.166 |
structurally_consistent (Q9UM13)
|
| FZR1 | ANAPC15 | 0.978 | 0.2 |
mutually_exclusive (O43684)
|
| CDC20 | ANAPC4 | 0.978 | 0.052 | |
| ANAPC4 | CFAP97 | 0.978 | 0.08 | |
| CDC20 | ANAPC15 | 0.977 | 0.148 | |
| ANAPC10 | CFAP97 | 0.977 | 0.078 | |
| NEK2 | CDC27 | 0.977 | 0.084 | |
| CDC20 | ANAPC10 | 0.976 | 0.254 |
structurally_consistent (dimer)
|
| ANAPC5 | CFAP97 | 0.975 | 0.11 | |
| CDC16 | NEK2 | 0.974 | 0.202 | |
| BUB1B | ANAPC16 | 0.974 | 0.298 | |
| GNPTAB | ANAPC4 | 0.973 | 0.094 | |
| FZR1 | BUB1B | 0.971 | 0.146 |
mutually_exclusive (O43684)
|
| CDC20 | NEK2 | 0.97 | 0.2128875 | |
| NEK2 | ANAPC4 | 0.967 | 0.07 | |
| FZR1 | GNPTAB | 0.967 | 0.134 | |
| GNPTAB | CDC27 | 0.967 | 0.048 | |
| GNPTAB | ANAPC10 | 0.966 | 0.128 | |
| NEK2 | FBXO5 | 0.966 | 0.178 | |
| ANAPC15 | FBXO5 | 0.966 | 0.154 | |
| CDC23 | NEK2 | 0.964 | 0.116 | |
| ANAPC15 | ANAPC13 | 0.962 | 0.2 | |
| RRM2 | ANAPC10 | 0.962 | 0.148 | |
| BUB1B | ANAPC10 | 0.961 | 0.178 |
mutually_exclusive (O43684)
|
| ANAPC7 | CFAP97 | 0.96 | 0.074 | |
| BUB1B | CDC16 | 0.957 | 0.1 | |
| ANAPC15 | ANAPC10 | 0.956 | 0.274 |
mutually_exclusive (O43684)
|
| CDC20 | ANAPC7 | 0.953 | 0.052 | |
| BUB1B | FBXO5 | 0.952 | 0.198 | |
| GNPTAB | ANAPC1 | 0.947 | 0.102 | |
| ANAPC15 | CFAP97 | 0.944 | 0.152 | |
| RRM2 | BUB1B | 0.937 | 0.406 | |
| GNPTAB | CDC20 | 0.936 | 0.180560283688 | |
| RRM2 | ANAPC7 | 0.933 | 0.044 | |
| RRM2 | ANAPC15 | 0.931 | 0.138 | |
| ANAPC15 | NEK2 | 0.93 | 0.118 | |
| RRM2 | ANAPC4 | 0.93 | 0.102 | |
| GNPTAB | ANAPC15 | 0.926 | 0.114 | |
| RRM2 | GNPTAB | 0.921 | 0.084 | |
| BUB1B | ANAPC5 | 0.92 | 0.070219858156 | |
| BUB1B | CDC27 | 0.912 | 0.118 | |
| BUB1B | ANAPC15 | 0.905 | 0.192 |
mutually_exclusive (O43684)
|
| CDC20 | CFAP97 | 0.904 | 0.158560283688 | |
| BUB1B | ANAPC13 | 0.903 | 0.168320754717 | |
| RRM2 | ANAPC5 | 0.899 | 0.094 | |
| RRM2 | CDC20 | 0.894 | 0.324 | |
| BUB1B | ANAPC1 | 0.842 | 0.224 | |
| BUB1B | NEK2 | 0.811 | 0.176 | |
| GNPTAB | BUB1B | 0.795 | 0.078 | |
| GNPTAB | CFAP97 | 0.785 | 0.11 | |
| GNPTAB | NEK2 | 0.785 | 0.32 | |
| BUB1B | ANAPC7 | 0.782 | 0.072 | |
| BUB1B | CFAP97 | 0.772 | 0.086 | |
| BUB1B | ANAPC4 | 0.746 | 0.086 | |
| RRM2 | ANAPC1 | 0.714 | 0.08 | |
| RRM2 | NEK2 | 0.648 | 0.116 | |
| RRM2 | CFAP97 | 0.528 | 0.078 |
Related Complexes
| Genename | Complexes |
|---|---|
| RRM2 | huMAP3_03279.1 huMAP3_03388.1 huMAP3_07989.1 huMAP3_11033.1 huMAP3_12747.1 |
| GNPTAB | huMAP3_03378.1 huMAP3_03388.1 huMAP3_11112.1 huMAP3_11412.1 |
| BUB1B | huMAP3_03388.1 huMAP3_12747.1 |
| ANAPC16 | huMAP3_03388.1 huMAP3_12747.1 |
| FZR1 | huMAP3_00732.1 huMAP3_03388.1 huMAP3_07079.1 huMAP3_09021.1 huMAP3_12747.1 huMAP3_13744.1 |
| CDC20 | huMAP3_03388.1 huMAP3_12747.1 |
| ANAPC15 | huMAP3_03388.1 huMAP3_12747.1 |
| CDC23 | huMAP3_03388.1 huMAP3_12747.1 |
| ANAPC13 | huMAP3_03388.1 huMAP3_12747.1 |
| CDC16 | huMAP3_03388.1 huMAP3_12097.1 huMAP3_12747.1 |
| NEK2 | huMAP3_03388.1 huMAP3_12747.1 |
| ANAPC10 | huMAP3_03388.1 huMAP3_12747.1 |
| CDC26 | huMAP3_03388.1 huMAP3_12747.1 |
| ANAPC7 | huMAP3_03388.1 huMAP3_12747.1 |
| ANAPC4 | huMAP3_03388.1 huMAP3_12747.1 |
| ANAPC1 | huMAP3_03388.1 huMAP3_12747.1 |
| CDC27 | huMAP3_03388.1 huMAP3_12747.1 |
| ANAPC5 | huMAP3_03388.1 huMAP3_12747.1 |
| CFAP97 | huMAP3_03388.1 huMAP3_12747.1 huMAP3_15205.1 |
| ANAPC2 | huMAP3_03388.1 huMAP3_12747.1 |
| FBXO5 | huMAP3_03388.1 huMAP3_12747.1 |