hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03391.1
Complex Portal: CPX-12345
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MAN1A1 | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Man(9)-alpha-mannosidase) (Man9-mannosidase) (Mannosidase alpha class 1A member 1) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA) | 5 | UniProt NCBI |
| BPNT2 | Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (Golgi-resident PAP phosphatase) (gPAPP) (EC 3.1.3.7) (3'(2'), 5'-bisphosphate nucleotidase 2) (Inositol monophosphatase domain-containing protein 1) (Myo-inositol monophosphatase A3) (Phosphoadenosine phosphate 3'-nucleotidase) | 5 | UniProt NCBI |
| MGAT2 | Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC 2.4.1.143) (Beta-1,2-N-acetylglucosaminyltransferase II) (GlcNAc-T II) (GNT-II) (Mannoside acetylglucosaminyltransferase 2) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0009603 | 0.00294248773717 | 1.0 | BPNT2 MGAT2 | Deviation of the thumb |
| KEGG:00920 | 0.0237506195141 | 0.5 | BPNT2 | Sulfur metabolism |
| REAC:R-HSA-4793952 | 0.0249718442457 | 0.5 | MGAT2 | Defective MGAT2 causes CDG-2a |
| CORUM:6112 | 0.0499419797295 | 0.5 | MGAT2 | DGAT2-MGAT2 complex |
| CORUM:6622 | 0.0499419797295 | 0.5 | MGAT2 | MGAT2-SLC35A3 complex |
| HP:0003842 | 0.0499436884913 | 0.5 | BPNT2 | Irregular epiphyses of the upper limbs |
| HP:0009190 | 0.0499436884913 | 0.5 | BPNT2 | Irregular epiphyses of the metacarpals |
| HP:0500173 | 0.0499436884913 | 0.5 | MGAT2 | Reflex asystolic syncope |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MAN1A1 | MGAT2 | 0.987 | 0.094 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| MAN1A1 | BPNT2 | 0.953 | 0.104 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| BPNT2 | MGAT2 | 0.854 | 0.114 |
mutually_exclusive (P33908)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
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