hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03395.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PTGR3 | Prostaglandin reductase 3 (PRG-3) (EC 1.3.1.48) (Zinc-binding alcohol dehydrogenase domain-containing protein 2) | 4 | UniProt NCBI |
| GKN1 | Gastrokine-1 (18 kDa antrum mucosa protein) (AMP-18) (Protein CA11) | 5 | UniProt NCBI |
| CFL1 | Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform) | 5 | UniProt NCBI |
| JMY | Junction-mediating and -regulatory protein | 5 | UniProt NCBI |
| DSTN | Destrin (Actin-depolymerizing factor) (ADF) | 5 | UniProt NCBI |
| CFL2 | Cofilin-2 (Cofilin, muscle isoform) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0030043 | 1.92240082153e-06 | 0.5 | CFL2 CFL1 DSTN | actin filament fragmentation |
| GO:0051014 | 0.0010743908712 | 0.5 | CFL2 CFL1 DSTN | actin filament severing |
| WP:WP524 | 0.00529013036744 | 0.333333333333 | CFL2 CFL1 | G13 signaling pathway |
| KEGG:05133 | 0.0123104747863 | 0.333333333333 | CFL2 CFL1 | Pertussis |
| GO:0030042 | 0.0148589937997 | 0.5 | CFL2 CFL1 DSTN | actin filament depolymerization |
| KEGG:04666 | 0.0286526780492 | 0.333333333333 | CFL2 CFL1 | Fc gamma R-mediated phagocytosis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CFL2 | CFL1 | 0.999 | 0.918 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM treiber_WMM WMM_only |
| GKN1 | JMY | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CFL1 | DSTN | 0.983 | 0.572 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction treiber_WMM |
| JMY | CFL2 | 0.982 | 0.026 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| CFL2 | DSTN | 0.979 | 0.476 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM treiber_WMM WMM_only |
| PTGR3 | JMY | 0.976 | 0.036 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| JMY | DSTN | 0.97 | 0.06 | hein_WMM bioplex3_WMM WMM_only |
| JMY | CFL1 | 0.969 | 0.142 | hein_WMM bioplex3_HEK293 bioplex () bioplex3_WMM youn_WMM |
| GKN1 | CFL1 | 0.459 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 | |
| GKN1 | DSTN | 0.012 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PTGR3 | CFL1 | 0.008 | 0.052 | bioplex3_HEK293 bioplex () bioplex3_WMM youn_WMM bioplex3_HCT116 |
| PTGR3 | DSTN | 0.006 | 0.032 | youn_WMM WMM_only |
| PTGR3 | CFL2 | 0.006 | 0.03 | bioplex3_HEK293 bioplex () youn_WMM bioplex3_HCT116 |
| GKN1 | CFL2 | 0.005 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 |
Related Complexes