hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_03400.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PARD6G | Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D) | 5 | UniProt NCBI |
| LLGL1 | Lethal(2) giant larvae protein homolog 1 (LLGL) (DLG4) (Hugl-1) (Human homolog to the D-lgl gene protein) | 5 | UniProt NCBI |
| PARD3 | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | 5 | UniProt NCBI |
| PTPN21 | Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1) | 5 | UniProt NCBI |
| PARD6B | Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-420029 | 1.41820648707e-06 | 0.6 | PARD6G PARD3 PARD6B | Tight junction interactions |
| KEGG:04530 | 1.88806560974e-06 | 0.8 | PARD6G PARD6B LLGL1 PARD3 | Tight junction |
| KEGG:04390 | 2.3020533386e-06 | 0.8 | PARD6G PARD6B LLGL1 PARD3 | Hippo signaling pathway |
| GO:0045197 | 9.69325556185e-06 | 0.8 | PARD6G PARD6B LLGL1 PARD3 | establishment or maintenance of epithelial cell apical/basal polarity |
| GO:0035088 | 1.32964092214e-05 | 0.8 | PARD6G PARD6B LLGL1 PARD3 | establishment or maintenance of apical/basal cell polarity |
| GO:0061245 | 1.32964092214e-05 | 0.8 | PARD6G PARD6B LLGL1 PARD3 | establishment or maintenance of bipolar cell polarity |
| GO:0120157 | 1.92180881975e-05 | 0.6 | PARD6G PARD3 PARD6B | PAR polarity complex |
| KEGG:05165 | 3.83376375862e-05 | 0.8 | PARD6G PARD6B LLGL1 PARD3 | Human papillomavirus infection |
| CORUM:959 | 4.09448956317e-05 | 0.4 | LLGL1 PARD6B | LLGL1-PAR-6B-PRKCI complex |
| CORUM:956 | 4.09448956317e-05 | 0.4 | PARD3 PARD6B | PAR-3-PAR-6B-PRKCI complex |
| REAC:R-HSA-421270 | 4.40931593476e-05 | 0.6 | PARD6G PARD3 PARD6B | Cell-cell junction organization |
| WP:WP5090 | 0.000135925027505 | 0.6 | PARD6G PARD3 PARD6B | Complement system in neuronal development and plasticity |
| REAC:R-HSA-446728 | 0.00018480745401 | 0.6 | PARD6G PARD3 PARD6B | Cell junction organization |
| WP:WP5381 | 0.000532897197774 | 0.6 | PARD6B LLGL1 PARD3 | Smith Magenis and Potocki Lupski syndrome copy number variation |
| REAC:R-HSA-1500931 | 0.000546262833483 | 0.6 | PARD6G PARD3 PARD6B | Cell-Cell communication |
| KEGG:04360 | 0.000548434275739 | 0.6 | PARD6G PARD3 PARD6B | Axon guidance |
| KEGG:04015 | 0.000687014133415 | 0.6 | PARD6G PARD3 PARD6B | Rap1 signaling pathway |
| KEGG:04144 | 0.00184833104877 | 0.6 | PARD6G PARD3 PARD6B | Endocytosis |
| GO:0007163 | 0.00309714791762 | 0.8 | PARD6G PARD6B LLGL1 PARD3 | establishment or maintenance of cell polarity |
| GO:0005938 | 0.00480818953079 | 0.8 | PARD6G PARD6B LLGL1 PARD3 | cell cortex |
| GO:0005911 | 0.0451460478376 | 0.8 | PARD6G PARD6B LLGL1 PARD3 | cell-cell junction |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| LLGL1 | PARD6B | 1.0 | 0.12 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| PARD3 | PARD6B | 0.998 | 0.116 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| PARD6G | PARD6B | 0.998 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PTPN21 | PARD6B | 0.991 | 0.158 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PARD3 | LLGL1 | 0.864 | 0.034 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| PARD6G | LLGL1 | 0.815 | bioplex_WMM bioplex3_WMM WMM_only | |
| PARD3 | PTPN21 | 0.357 | 0.062 | bioplex_WMM bioplex3_WMM WMM_only |
| PTPN21 | LLGL1 | 0.217 | 0.056 | bioplex_WMM bioplex3_WMM WMM_only |
| PARD3 | PARD6G | 0.07 | bioplex3_WMM WMM_only boldt_WMM | |
| PTPN21 | PARD6G | 0.046 | bioplex3_WMM WMM_only |
Related Complexes