hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03401.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CASP3 | Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] | 5 | UniProt NCBI |
| ADAMTS4 | A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAM-TS 4) (ADAM-TS4) (ADAMTS-4) (EC 3.4.24.82) (ADMP-1) (Aggrecanase-1) | 5 | UniProt NCBI |
| CASP7 | Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] | 5 | UniProt NCBI |
| XIAP | E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP) | 5 | UniProt NCBI |
| MORN3 | MORN repeat-containing protein 3 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-111459 | 3.12013984232e-08 | 0.6 | XIAP CASP3 CASP7 | Activation of caspases through apoptosome-mediated cleavage |
| REAC:R-HSA-111463 | 6.23963902515e-08 | 0.6 | XIAP CASP3 CASP7 | SMAC (DIABLO) binds to IAPs |
| REAC:R-HSA-111464 | 6.23963902515e-08 | 0.6 | XIAP CASP3 CASP7 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes |
| REAC:R-HSA-111469 | 6.23963902515e-08 | 0.6 | XIAP CASP3 CASP7 | SMAC, XIAP-regulated apoptotic response |
| REAC:R-HSA-111461 | 6.85937538545e-07 | 0.6 | XIAP CASP3 CASP7 | Cytochrome c-mediated apoptotic response |
| REAC:R-HSA-111471 | 2.11908198931e-06 | 0.6 | XIAP CASP3 CASP7 | Apoptotic factor-mediated response |
| KEGG:04215 | 3.40083344402e-06 | 0.6 | XIAP CASP3 CASP7 | Apoptosis - multiple species |
| REAC:R-HSA-109606 | 6.86227830674e-05 | 0.6 | XIAP CASP3 CASP7 | Intrinsic Pathway for Apoptosis |
| WP:WP254 | 7.45653773707e-05 | 0.6 | XIAP CASP3 CASP7 | Apoptosis |
| WP:WP1772 | 9.11588292513e-05 | 0.6 | XIAP CASP3 CASP7 | Apoptosis modulation and signaling |
| KEGG:04668 | 0.000127952595628 | 0.6 | XIAP CASP3 CASP7 | TNF signaling pathway |
| WP:WP5090 | 0.000135925027505 | 0.6 | XIAP CASP3 CASP7 | Complement system in neuronal development and plasticity |
| KEGG:04210 | 0.000258943315877 | 0.6 | XIAP CASP3 CASP7 | Apoptosis |
| WP:WP3853 | 0.000264396631677 | 0.4 | CASP3 CASP7 | ERK pathway in Huntington 39 s disease |
| WP:WP5182 | 0.000534376000489 | 0.4 | CASP3 CASP7 | Pro survival signaling of neuroprotectin D1 |
| WP:WP384 | 0.000798299856649 | 0.4 | CASP3 CASP7 | Apoptosis modulation by HSP70 |
| REAC:R-HSA-264870 | 0.000835043279679 | 0.4 | CASP3 CASP7 | Caspase-mediated cleavage of cytoskeletal proteins |
| WP:WP2507 | 0.00100346979189 | 0.4 | CASP3 CASP7 | Nanomaterial induced apoptosis |
| WP:WP4864 | 0.0011148137474 | 0.4 | CASP3 CASP7 | Host pathogen interaction of human coronaviruses apoptosis |
| WP:WP1433 | 0.00190535175424 | 0.4 | XIAP CASP7 | Nucleotide binding oligomerization domain NOD pathway |
| REAC:R-HSA-109581 | 0.00229748232928 | 0.6 | XIAP CASP3 CASP7 | Apoptosis |
| WP:WP2371 | 0.00328532749654 | 0.4 | CASP3 CASP7 | Parkinson 39 s disease pathway |
| REAC:R-HSA-5357801 | 0.00366621179409 | 0.6 | XIAP CASP3 CASP7 | Programmed Cell Death |
| WP:WP2036 | 0.00368839425913 | 0.4 | CASP3 CASP7 | TNF related weak inducer of apoptosis TWEAK signaling pathway |
| WP:WP314 | 0.0041146517648 | 0.4 | CASP3 CASP7 | Fas ligand pathway and stress induction of heat shock proteins |
| WP:WP3646 | 0.00503666229327 | 0.4 | CASP3 CASP7 | Hepatitis C and hepatocellular carcinoma |
| KEGG:05134 | 0.00509527283003 | 0.4 | CASP3 CASP7 | Legionellosis |
| WP:WP3286 | 0.00553237697975 | 0.4 | XIAP CASP3 | Copper homeostasis |
| KEGG:05133 | 0.00771708586936 | 0.4 | CASP3 CASP7 | Pertussis |
| WP:WP2374 | 0.0080488533074 | 0.4 | CASP3 CASP7 | Oncostatin M signaling pathway |
| REAC:R-HSA-111465 | 0.00900400267976 | 0.4 | CASP3 CASP7 | Apoptotic cleavage of cellular proteins |
| KEGG:01524 | 0.0108758996329 | 0.4 | XIAP CASP3 | Platinum drug resistance |
| KEGG:04623 | 0.0108758996329 | 0.4 | CASP3 CASP7 | Cytosolic DNA-sensing pathway |
| WP:WP2328 | 0.0128896073912 | 0.4 | CASP3 CASP7 | Allograft rejection |
| KEGG:05200 | 0.0130900202546 | 0.6 | XIAP CASP3 CASP7 | Pathways in cancer |
| GO:0072734 | 0.0140440992017 | 0.4 | CASP3 CASP7 | cellular response to staurosporine |
| GO:0072733 | 0.0140440992017 | 0.4 | CASP3 CASP7 | response to staurosporine |
| WP:WP4298 | 0.0144790152013 | 0.4 | CASP3 CASP7 | Acute viral myocarditis |
| KEGG:05222 | 0.0164241113683 | 0.4 | XIAP CASP3 | Small cell lung cancer |
| REAC:R-HSA-75153 | 0.0177620315324 | 0.4 | CASP3 CASP7 | Apoptotic execution phase |
| KEGG:05145 | 0.0183886697314 | 0.4 | XIAP CASP3 | Toxoplasmosis |
| WP:WP231 | 0.020275205407 | 0.4 | CASP3 CASP7 | TNF alpha signaling pathway |
| REAC:R-HSA-5218859 | 0.0208015819243 | 0.4 | XIAP CASP3 | Regulated Necrosis |
| KEGG:04148 | 0.0340898047114 | 0.4 | CASP3 CASP7 | Efferocytosis |
| KEGG:04932 | 0.0427854405203 | 0.4 | CASP3 CASP7 | Non-alcoholic fatty liver disease |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| XIAP | ADAMTS4 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CASP7 | XIAP | 0.987 | 0.21 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| CASP3 | XIAP | 0.979 | 0.06 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| MORN3 | XIAP | 0.975 | bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes