hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03408.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PIK3C2A | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-alpha) | 5 | UniProt NCBI |
| DENND1A | DENN domain-containing protein 1A (Connecdenn 1) (Connecdenn) (Protein FAM31A) | 5 | UniProt NCBI |
| BMP2K | BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1) | 5 | UniProt NCBI |
| DAB2 | Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2) | 5 | UniProt NCBI |
| GTSE1 | G2 and S phase-expressed protein 1 (GTSE-1) (Protein B99 homolog) | 5 | UniProt NCBI |
| PICALM | Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein) | 5 | UniProt NCBI |
| ZNF106 | Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) | 5 | UniProt NCBI |
| WNK1 | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | 5 | UniProt NCBI |
| CLTCL1 | Clathrin heavy chain 2 (Clathrin heavy chain on chromosome 22) (CLH-22) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8856828 | 0.000194687776626 | 0.444444444444 | PICALM CLTCL1 PIK3C2A DAB2 | Clathrin-mediated endocytosis |
| GO:0030136 | 0.000528631869008 | 0.555555555556 | PICALM DAB2 PIK3C2A CLTCL1 DENND1A | clathrin-coated vesicle |
| REAC:R-HSA-199991 | 0.00238452036519 | 0.555555555556 | PICALM DAB2 PIK3C2A CLTCL1 DENND1A | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.00310840446846 | 0.555555555556 | PICALM DAB2 PIK3C2A CLTCL1 DENND1A | Vesicle-mediated transport |
| GO:0006897 | 0.00346340802694 | 0.666666666667 | PICALM PIK3C2A DENND1A CLTCL1 DAB2 BMP2K | endocytosis |
| REAC:R-HSA-196025 | 0.00438093013445 | 0.222222222222 | CLTCL1 DAB2 | Formation of annular gap junctions |
| GO:0030135 | 0.00474061028591 | 0.555555555556 | PICALM DAB2 PIK3C2A CLTCL1 DENND1A | coated vesicle |
| REAC:R-HSA-8856825 | 0.0049873114417 | 0.333333333333 | PICALM DAB2 CLTCL1 | Cargo recognition for clathrin-mediated endocytosis |
| REAC:R-HSA-190873 | 0.00525543712779 | 0.222222222222 | CLTCL1 DAB2 | Gap junction degradation |
| GO:1903077 | 0.0106791414882 | 0.333333333333 | PICALM DAB2 WNK1 | negative regulation of protein localization to plasma membrane |
| HP:0008000 | 0.0137554449829 | 0.222222222222 | CLTCL1 WNK1 | Decreased corneal reflex |
| GO:1904376 | 0.0142113571615 | 0.333333333333 | PICALM DAB2 WNK1 | negative regulation of protein localization to cell periphery |
| HP:0034251 | 0.0168068410612 | 0.222222222222 | CLTCL1 WNK1 | Abnormal corneal reflex |
| GO:0098657 | 0.0171338571064 | 0.666666666667 | PICALM PIK3C2A DENND1A CLTCL1 DAB2 BMP2K | import into cell |
| GO:1905476 | 0.020844368733 | 0.333333333333 | PICALM DAB2 WNK1 | negative regulation of protein localization to membrane |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PICALM | BMP2K | 0.998 | 0.118 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| PIK3C2A | BMP2K | 0.997 | 0.156 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| BMP2K | DAB2 | 0.996 | 0.036 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| PICALM | DAB2 | 0.995 | 0.158 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
| PIK3C2A | CLTCL1 | 0.994 | 0.136 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| PICALM | CLTCL1 | 0.994 | 0.378 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () gupta_WMM |
| PICALM | PIK3C2A | 0.993 | 0.132 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| GTSE1 | DENND1A | 0.989 | 0.102 | hein_WMM bioplex3_WMM hein () |
| BMP2K | WNK1 | 0.988 | 0.17 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| GTSE1 | ZNF106 | 0.987 | 0.12 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
| ZNF106 | CLTCL1 | 0.987 | 0.092 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| GTSE1 | PICALM | 0.984 | 0.166 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| PIK3C2A | ZNF106 | 0.983 | 0.128 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| BMP2K | ZNF106 | 0.982 | 0.052 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| PIK3C2A | DENND1A | 0.981 | 0.12 | hein_WMM bioplex3_WMM youn_WMM WMM_only boldt_WMM |
| ZNF106 | WNK1 | 0.981 | 0.05 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| DENND1A | CLTCL1 | 0.977 | 0.126 | hein_WMM bioplex3_WMM WMM_only |
| DENND1A | BMP2K | 0.976 | 0.12 | hein_WMM bioplex3_WMM youn_WMM WMM_only |
| PICALM | DENND1A | 0.976 | 0.136 | hein_WMM bioplex3_WMM youn_WMM hein () |
| PIK3C2A | DAB2 | 0.973 | 0.136 | hein_WMM bioplex3_WMM youn_WMM WMM_only bioplex_WMM |
| GTSE1 | WNK1 | 0.973 | 0.122 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| GTSE1 | BMP2K | 0.963 | 0.126 | hein_WMM bioplex_WMM bioplex3_WMM hein () gupta_WMM |
| PICALM | ZNF106 | 0.96 | 0.066 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| GTSE1 | CLTCL1 | 0.959 | 0.144 | hein_WMM bioplex_WMM bioplex3_WMM hein () gupta_WMM |
| GTSE1 | PIK3C2A | 0.958 | 0.138 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| BMP2K | CLTCL1 | 0.952 | 0.088 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| DENND1A | DAB2 | 0.943 | 0.05 | hein_WMM youn_WMM WMM_only |
| GTSE1 | DAB2 | 0.935 | 0.092 | hein_WMM hein () |
| PIK3C2A | WNK1 | 0.906 | 0.07 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| DENND1A | WNK1 | 0.88 | 0.09 | hein_WMM youn_WMM WMM_only |
| PICALM | WNK1 | 0.836 | 0.07 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM fraction |
| WNK1 | CLTCL1 | 0.831 | 0.214 | hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| DAB2 | CLTCL1 | 0.815 | 0.164347826087 | hein_WMM bioplex3_WMM WMM_only |
| DAB2 | WNK1 | 0.781 | 0.024 | hein_WMM bioplex3_WMM youn_WMM WMM_only |
| DAB2 | ZNF106 | 0.781 | 0.114 | hein_WMM WMM_only |
| DENND1A | ZNF106 | 0.149 | 0.062 | hein_WMM WMM_only |
Related Complexes