hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_03417.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RAD51D | DNA repair protein RAD51 homolog 4 (R51H3) (RAD51 homolog D) (RAD51-like protein 3) (TRAD) | 5 | UniProt NCBI |
| RAD51B | DNA repair protein RAD51 homolog 2 (R51H2) (RAD51 homolog B) (Rad51B) (RAD51-like protein 1) | 5 | UniProt NCBI |
| XRCC2 | DNA repair protein XRCC2 (X-ray repair cross-complementing protein 2) | 5 | UniProt NCBI |
| RAD51C | DNA repair protein RAD51 homolog 3 (R51H3) (RAD51 homolog C) (RAD51-like protein 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:251 | 4.80157500167e-14 | 1.0 | XRCC2 RAD51C RAD51D RAD51B | BCDX2 complex |
| CORUM:68 | 4.80157500167e-14 | 1.0 | XRCC2 RAD51C RAD51D RAD51B | BCDX2 complex |
| CORUM:258 | 4.80157500167e-14 | 1.0 | XRCC2 RAD51C RAD51D RAD51B | BCDX2 complex |
| CORUM:261 | 2.40078750084e-13 | 1.0 | XRCC2 RAD51C RAD51D RAD51B | RAD51B-RAD51C-RAD51D-XRCC2-XRCC3 complex |
| GO:0033063 | 2.63126310092e-11 | 1.0 | XRCC2 RAD51C RAD51D RAD51B | Rad51B-Rad51C-Rad51D-XRCC2 complex |
| GO:0033061 | 3.94689465137e-10 | 1.0 | XRCC2 RAD51C RAD51D RAD51B | DNA recombinase mediator complex |
| REAC:R-HSA-9709603 | 1.02043071936e-09 | 1.0 | XRCC2 RAD51C RAD51D RAD51B | Impaired BRCA2 binding to PALB2 |
| REAC:R-HSA-9701192 | 1.21479847542e-09 | 1.0 | XRCC2 RAD51C RAD51D RAD51B | Defective homologous recombination repair (HRR) due to BRCA1 loss of function |
| REAC:R-HSA-9704646 | 1.21479847542e-09 | 1.0 | XRCC2 RAD51C RAD51D RAD51B | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function |
| REAC:R-HSA-9704331 | 1.21479847542e-09 | 1.0 | XRCC2 RAD51C RAD51D RAD51B | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function |
| REAC:R-HSA-9701193 | 1.21479847542e-09 | 1.0 | XRCC2 RAD51C RAD51D RAD51B | Defective homologous recombination repair (HRR) due to PALB2 loss of function |
| REAC:R-HSA-5693554 | 1.68535282559e-09 | 1.0 | XRCC2 RAD51C RAD51D RAD51B | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) |
| KEGG:03440 | 2.14706370351e-09 | 1.0 | XRCC2 RAD51C RAD51D RAD51B | Homologous recombination |
| REAC:R-HSA-5693568 | 3.92960898137e-09 | 1.0 | XRCC2 RAD51C RAD51D RAD51B | Resolution of D-loop Structures through Holliday Junction Intermediates |
| REAC:R-HSA-5693537 | 4.45355684555e-09 | 1.0 | XRCC2 RAD51C RAD51D RAD51B | Resolution of D-Loop Structures |
| REAC:R-HSA-5693616 | 7.89868690925e-09 | 1.0 | XRCC2 RAD51C RAD51D RAD51B | Presynaptic phase of homologous DNA pairing and strand exchange |
| REAC:R-HSA-9675136 | 8.77631878805e-09 | 1.0 | XRCC2 RAD51C RAD51D RAD51B | Diseases of DNA Double-Strand Break Repair |
| REAC:R-HSA-9701190 | 8.77631878805e-09 | 1.0 | XRCC2 RAD51C RAD51D RAD51B | Defective homologous recombination repair (HRR) due to BRCA2 loss of function |
| REAC:R-HSA-5693579 | 1.07488057987e-08 | 1.0 | XRCC2 RAD51C RAD51D RAD51B | Homologous DNA Pairing and Strand Exchange |
| REAC:R-HSA-9675135 | 2.03467701011e-08 | 1.0 | XRCC2 RAD51C RAD51D RAD51B | Diseases of DNA repair |
| GO:0000400 | 6.26240618018e-08 | 1.0 | XRCC2 RAD51C RAD51D RAD51B | four-way junction DNA binding |
| REAC:R-HSA-5685942 | 6.92118227041e-08 | 1.0 | XRCC2 RAD51C RAD51D RAD51B | HDR through Homologous Recombination (HRR) |
| REAC:R-HSA-5693567 | 8.71834457148e-07 | 1.0 | XRCC2 RAD51C RAD51D RAD51B | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-5693538 | 1.05724689171e-06 | 1.0 | XRCC2 RAD51C RAD51D RAD51B | Homology Directed Repair |
| GO:0000217 | 1.07671286089e-06 | 1.0 | XRCC2 RAD51C RAD51D RAD51B | DNA secondary structure binding |
| REAC:R-HSA-5693532 | 2.40002357025e-06 | 1.0 | XRCC2 RAD51C RAD51D RAD51B | DNA Double-Strand Break Repair |
| CORUM:262 | 5.12628525639e-06 | 0.5 | RAD51D XRCC2 | RAD51L3-XRCC2 complex |
| CORUM:256 | 5.12628525639e-06 | 0.5 | RAD51B RAD51C | RAD51B-RAD51C complex |
| CORUM:260 | 5.12628525639e-06 | 0.5 | RAD51B RAD51C | RAD51B-RAD51C complex |
| CORUM:2228 | 1.53774525569e-05 | 0.5 | RAD51D XRCC2 | BLM-RAD51L3-XRCC2 complex |
| GO:0005657 | 1.78147036984e-05 | 1.0 | XRCC2 RAD51C RAD51D RAD51B | replication fork |
| REAC:R-HSA-73894 | 3.4398535169e-05 | 1.0 | XRCC2 RAD51C RAD51D RAD51B | DNA Repair |
| GO:0051321 | 0.000624628048426 | 1.0 | XRCC2 RAD51C RAD51D RAD51B | meiotic cell cycle |
| GO:0000724 | 0.000657606458249 | 1.0 | XRCC2 RAD51C RAD51D RAD51B | double-strand break repair via homologous recombination |
| GO:0000725 | 0.0007274632045 | 1.0 | XRCC2 RAD51C RAD51D RAD51B | recombinational repair |
| HP:0030406 | 0.00303997345979 | 0.5 | RAD51D RAD51C | Primary peritoneal carcinoma |
| GO:0007131 | 0.00350727150095 | 0.75 | RAD51C RAD51D RAD51B | reciprocal meiotic recombination |
| GO:0140527 | 0.00350727150095 | 0.75 | RAD51C RAD51D RAD51B | reciprocal homologous recombination |
| GO:0006310 | 0.00398236447266 | 1.0 | XRCC2 RAD51C RAD51D RAD51B | DNA recombination |
| GO:0006302 | 0.00569790407237 | 1.0 | XRCC2 RAD51C RAD51D RAD51B | double-strand break repair |
| GO:0035825 | 0.00622026610693 | 0.75 | RAD51C RAD51D RAD51B | homologous recombination |
| HP:0005522 | 0.00771122114953 | 0.5 | XRCC2 RAD51C | Pyridoxine-responsive sideroblastic anemia |
| HP:0010469 | 0.00844485194452 | 0.5 | XRCC2 RAD51C | Absent testis |
| HP:0011027 | 0.0108451581837 | 0.5 | RAD51D RAD51C | Abnormal fallopian tube morphology |
| HP:0010293 | 0.0117117011059 | 0.5 | XRCC2 RAD51C | Aplasia/Hypoplasia of the uvula |
| HP:0012848 | 0.0117117011059 | 0.5 | XRCC2 RAD51C | Small intestinal stenosis |
| HP:0100867 | 0.0117117011059 | 0.5 | XRCC2 RAD51C | Duodenal stenosis |
| HP:0100760 | 0.0126114492305 | 0.5 | XRCC2 RAD51C | Clubbing of toes |
| HP:0002245 | 0.0126114492305 | 0.5 | XRCC2 RAD51C | Meckel diverticulum |
| HP:0100587 | 0.0145105245688 | 0.5 | XRCC2 RAD51C | Abnormal preputium morphology |
| HP:0001924 | 0.0165423111708 | 0.5 | XRCC2 RAD51C | Sideroblastic anemia |
| HP:0012125 | 0.0176079483787 | 0.5 | RAD51D RAD51C | Prostate cancer |
| HP:0100787 | 0.0176079483787 | 0.5 | RAD51D RAD51C | Prostate neoplasm |
| REAC:R-HSA-1643685 | 0.0193799289378 | 1.0 | XRCC2 RAD51C RAD51D RAD51B | Disease |
| GO:0007127 | 0.0209740664347 | 0.75 | RAD51C RAD51D RAD51B | meiosis I |
| HP:0002984 | 0.0222019103471 | 0.5 | XRCC2 RAD51C | Hypoplasia of the radius |
| HP:0040012 | 0.0222019103471 | 0.5 | XRCC2 RAD51C | Chromosome breakage |
| HP:0001549 | 0.0222019103471 | 0.5 | XRCC2 RAD51C | Abnormal ileum morphology |
| HP:0008775 | 0.0246976114972 | 0.5 | RAD51D RAD51C | Abnormal prostate morphology |
| GO:0061982 | 0.0269276802074 | 0.75 | RAD51C RAD51D RAD51B | meiosis I cell cycle process |
| HP:0000813 | 0.0329787201379 | 0.5 | XRCC2 RAD51C | Bicornuate uterus |
| HP:0033019 | 0.0375654511359 | 0.5 | RAD51D RAD51C | Male reproductive system neoplasm |
| HP:0007874 | 0.0375654511359 | 0.5 | XRCC2 RAD51C | Almond-shaped palpebral fissure |
| HP:0100026 | 0.0391604009626 | 0.5 | XRCC2 RAD51C | Arteriovenous malformation |
| GO:0042148 | 0.042122686785 | 0.5 | RAD51D XRCC2 | DNA strand invasion |
| HP:0003022 | 0.0424493051949 | 0.5 | XRCC2 RAD51C | Hypoplasia of the ulna |
| GO:0019953 | 0.0435746031606 | 1.0 | XRCC2 RAD51C RAD51D RAD51B | sexual reproduction |
| HP:0003220 | 0.0441432413831 | 0.5 | XRCC2 RAD51C | Abnormality of chromosome stability |
| HP:0200005 | 0.0458701548093 | 0.5 | XRCC2 RAD51C | Abnormal shape of the palpebral fissure |
| HP:0009777 | 0.0458701548093 | 0.5 | XRCC2 RAD51C | Absent thumb |
| HP:0000008 | 0.0467645338244 | 0.75 | RAD51C RAD51D XRCC2 | Abnormal morphology of female internal genitalia |
| HP:0006495 | 0.049422876951 | 0.5 | XRCC2 RAD51C | Aplasia/Hypoplasia of the ulna |
| CORUM:5683 | 0.049938562206 | 0.25 | XRCC2 | hRAD51C-hXRCC3 complex |
| CORUM:1196 | 0.049938562206 | 0.25 | RAD51C | RAD51C-XRCC3 complex |
| CORUM:259 | 0.049938562206 | 0.25 | RAD51C | RAD51C-XRCC3 complex |
| CORUM:253 | 0.049938562206 | 0.25 | RAD51C | RAD51C-XRCC3 complex |
| CORUM:252 | 0.049938562206 | 0.25 | RAD51C | RAD51C-XRCC3 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RAD51D | XRCC2 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RAD51B | XRCC2 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RAD51B | RAD51C | 0.999 | 0.204 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| RAD51D | RAD51C | 0.998 | 0.146 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RAD51D | RAD51B | 0.997 | 0.186 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| XRCC2 | RAD51C | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| RAD51D | huMAP3_03417.1 huMAP3_07905.1 huMAP3_12173.1 huMAP3_12847.1 |
| RAD51B | huMAP3_03417.1 huMAP3_07905.1 huMAP3_12173.1 huMAP3_12847.1 |
| XRCC2 | huMAP3_03417.1 huMAP3_07905.1 huMAP3_12173.1 huMAP3_12847.1 huMAP3_14586.1 |
| RAD51C | huMAP3_03417.1 huMAP3_07905.1 huMAP3_11889.1 |