hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_03429.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PIAS1 | E3 SUMO-protein ligase PIAS1 (EC 2.3.2.-) (DEAD/H box-binding protein 1) (E3 SUMO-protein transferase PIAS1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein) | 5 | UniProt NCBI |
| SAE1 | SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed] | 5 | UniProt NCBI |
| TRIM35 | E3 ubiquitin-protein ligase TRIM35 (EC 2.3.2.27) (Hemopoietic lineage switch protein 5) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04120 | 0.00686279305854 | 0.666666666667 | PIAS1 SAE1 | Ubiquitin mediated proteolysis |
| REAC:R-HSA-877300 | 0.0193669984414 | 0.666666666667 | PIAS1 TRIM35 | Interferon gamma signaling |
| HPA:0500112 | 0.0463845343611 | 1.0 | TRIM35 PIAS1 SAE1 | soft tissue 1; chondrocytes[>=Medium] |
| CORUM:5756 | 0.0499402709677 | 0.333333333333 | SAE1 | SUA1-UBA2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PIAS1 | TRIM35 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SAE1 | TRIM35 | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SAE1 | PIAS1 | 0.205 | 0.156 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes