hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03468.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GCLM | Glutamate--cysteine ligase regulatory subunit (GCS light chain) (Gamma-ECS regulatory subunit) (Gamma-glutamylcysteine synthetase regulatory subunit) (Glutamate--cysteine ligase modifier subunit) | 5 | UniProt NCBI |
| GCLC | Glutamate--cysteine ligase catalytic subunit (EC 6.3.2.2) (GCS heavy chain) (Gamma-ECS) (Gamma-glutamylcysteine synthetase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7186 | 1.70876175213e-06 | 1.0 | GCLM GCLC | Glutamate-cysteine ligase |
| REAC:R-HSA-5578999 | 1.70876175213e-06 | 1.0 | GCLM GCLC | Defective GCLC causes HAGGSD |
| WP:WP3 | 3.87329686614e-05 | 1.0 | GCLM GCLC | Transcriptional activation by NRF2 in response to phytochemicals |
| WP:WP100 | 5.7886634483e-05 | 1.0 | GCLM GCLC | Glutathione metabolism |
| REAC:R-HSA-174403 | 9.39818963671e-05 | 1.0 | GCLM GCLC | Glutathione synthesis and recycling |
| WP:WP4357 | 9.83221512175e-05 | 1.0 | GCLM GCLC | NRF2 ARE regulation |
| WP:WP3612 | 9.83221512175e-05 | 1.0 | GCLM GCLC | Photodynamic therapy induced NFE2L2 NRF2 survival signaling |
| KEGG:04216 | 0.000102418907518 | 1.0 | GCLM GCLC | Ferroptosis |
| WP:WP5113 | 0.000138332030934 | 1.0 | GCLM GCLC | Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway |
| KEGG:00270 | 0.00016825963378 | 1.0 | GCLM GCLC | Cysteine and methionine metabolism |
| KEGG:00480 | 0.00019914787573 | 1.0 | GCLM GCLC | Glutathione metabolism |
| REAC:R-HSA-9818027 | 0.000205051410255 | 1.0 | GCLM GCLC | NFE2L2 regulating anti-oxidant/detoxification enzymes |
| REAC:R-HSA-5579029 | 0.00023239159829 | 1.0 | GCLM GCLC | Metabolic disorders of biological oxidation enzymes |
| WP:WP3940 | 0.000384350227487 | 1.0 | GCLM GCLC | One carbon metabolism and related pathways |
| GO:0004357 | 0.000468200720083 | 1.0 | GCLM GCLC | glutamate-cysteine ligase activity |
| GO:0017109 | 0.000468200720083 | 1.0 | GCLM GCLC | glutamate-cysteine ligase complex |
| WP:WP2525 | 0.000632070972113 | 1.0 | GCLM GCLC | Trans sulfuration one carbon metabolism and related pathways |
| WP:WP4313 | 0.00070357799118 | 1.0 | GCLM GCLC | Ferroptosis |
| REAC:R-HSA-156590 | 0.000847545829056 | 1.0 | GCLM GCLC | Glutathione conjugation |
| KEGG:01240 | 0.00144865854745 | 1.0 | GCLM GCLC | Biosynthesis of cofactors |
| WP:WP2884 | 0.00264575970549 | 1.0 | GCLM GCLC | NRF2 pathway |
| REAC:R-HSA-9759194 | 0.00513141154164 | 1.0 | GCLM GCLC | Nuclear events mediated by NFE2L2 |
| REAC:R-HSA-156580 | 0.00539968713673 | 1.0 | GCLM GCLC | Phase II - Conjugation of compounds |
| REAC:R-HSA-9755511 | 0.0091521279444 | 1.0 | GCLM GCLC | KEAP1-NFE2L2 pathway |
| GO:0006750 | 0.00983221512175 | 1.0 | GCLM GCLC | glutathione biosynthetic process |
| GO:0019184 | 0.0131096201623 | 1.0 | GCLM GCLC | nonribosomal peptide biosynthetic process |
| WP:WP2882 | 0.0133543614478 | 1.0 | GCLM GCLC | Nuclear receptors meta pathway |
| REAC:R-HSA-211859 | 0.0225607814134 | 1.0 | GCLM GCLC | Biological oxidations |
| REAC:R-HSA-9711123 | 0.0284560094582 | 1.0 | GCLM GCLC | Cellular response to chemical stress |
| REAC:R-HSA-5668914 | 0.0297170756313 | 1.0 | GCLM GCLC | Diseases of metabolism |
| WP:WP4518 | 0.0373151717536 | 0.5 | GCLC | Gamma glutamyl cycle for the biosynthesis and degradation of glutathione including diseases |
| WP:WP2333 | 0.049750157242 | 0.5 | GCLM | Trans sulfuration pathway |
| HP:0006904 | 0.0499436884913 | 0.5 | GCLC | Late-onset spinocerebellar degeneration |
| HP:6000132 | 0.0499436884913 | 0.5 | GCLC | Reduced erythrocyte gamma-glutamyl cysteine synthetase activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GCLM | GCLC | 1.0 | 0.104 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM bioplex3_HCT116 fraction |
Related Complexes
| Genename | Complexes |
|---|---|
| GCLM | huMAP3_03468.1 huMAP3_07229.1 huMAP3_11353.1 huMAP3_12407.1 huMAP3_14769.1 |
| GCLC | huMAP3_03468.1 huMAP3_11353.1 huMAP3_11687.1 huMAP3_12407.1 |