hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03477.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CDK3 | Cyclin-dependent kinase 3 (EC 2.7.11.22) (Cell division protein kinase 3) | 5 | UniProt NCBI |
| E2F5 | Transcription factor E2F5 (E2F-5) | 5 | UniProt NCBI |
| RBL2 | Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2) | 5 | UniProt NCBI |
| GMNN | Geminin | 5 | UniProt NCBI |
| E2F4 | Transcription factor E2F4 (E2F-4) | 5 | UniProt NCBI |
| RBL1 | Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1) | 5 | UniProt NCBI |
| CDK2 | Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5180 | 2.44449534404e-10 | 0.833333333333 | GMNN E2F4 RBL1 E2F5 RBL2 | DYRK1A involvement regarding cell proliferation in brain development |
| REAC:R-HSA-1362300 | 1.97831742843e-09 | 0.666666666667 | RBL1 E2F4 E2F5 RBL2 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 |
| REAC:R-HSA-1362277 | 4.43345168711e-09 | 0.666666666667 | RBL1 E2F4 E2F5 RBL2 | Transcription of E2F targets under negative control by DREAM complex |
| REAC:R-HSA-1538133 | 2.16411786968e-08 | 0.666666666667 | RBL1 E2F4 E2F5 RBL2 | G0 and Early G1 |
| REAC:R-HSA-69205 | 2.5402076735e-08 | 0.666666666667 | RBL1 E2F4 E2F5 RBL2 | G1/S-Specific Transcription |
| CORUM:2975 | 4.675933868e-08 | 0.5 | RBL1 E2F5 E2F4 | SMAD3-E2F4/5-p107-DP1 complex |
| CORUM:5117 | 4.675933868e-08 | 0.5 | E2F4 E2F5 RBL2 | RBL2 complex (DNMT1, E2F4, E2F5, HDAC1, SUV39H1, RBL2) |
| REAC:R-HSA-69206 | 5.64501636203e-08 | 0.833333333333 | GMNN E2F4 RBL1 E2F5 RBL2 | G1/S Transition |
| CORUM:1474 | 9.35042757897e-08 | 0.5 | RBL1 E2F5 E2F4 | SMAD3/4-E2F4/5-p107-DP1 complex |
| CORUM:5118 | 9.35042757897e-08 | 0.5 | E2F4 E2F5 RBL2 | RBL2 complex (E2F4, E2F5, HDAC1, SUV39H1, P300, RBL2) |
| REAC:R-HSA-453279 | 1.05210790032e-07 | 0.833333333333 | GMNN E2F4 RBL1 E2F5 RBL2 | Mitotic G1 phase and G1/S transition |
| REAC:R-HSA-69231 | 2.35704115547e-07 | 0.666666666667 | RBL1 E2F4 E2F5 RBL2 | Cyclin D associated events in G1 |
| REAC:R-HSA-69236 | 2.35704115547e-07 | 0.666666666667 | RBL1 E2F4 E2F5 RBL2 | G1 Phase |
| WP:WP179 | 4.00505303048e-06 | 0.666666666667 | RBL1 E2F4 E2F5 RBL2 | Cell cycle |
| WP:WP366 | 4.44015808998e-06 | 0.666666666667 | RBL1 E2F4 E2F5 RBL2 | TGF beta signaling pathway |
| REAC:R-HSA-6804114 | 4.79564882828e-06 | 0.5 | RBL1 RBL2 E2F4 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest |
| KEGG:04218 | 6.1704720267e-06 | 0.666666666667 | RBL1 E2F4 E2F5 RBL2 | Cellular senescence |
| KEGG:04110 | 8.36690855792e-06 | 0.666666666667 | RBL1 E2F4 E2F5 RBL2 | Cell cycle |
| CORUM:5159 | 1.70876175213e-05 | 0.333333333333 | RBL1 E2F4 | E2F4-p107-cyclinE complex |
| CORUM:5160 | 1.70876175213e-05 | 0.333333333333 | RBL2 E2F4 | E2F4-p130 complex |
| REAC:R-HSA-69242 | 3.65722772768e-05 | 0.666666666667 | GMNN E2F4 E2F5 RBL2 | S Phase |
| REAC:R-HSA-2173796 | 5.02070457715e-05 | 0.5 | RBL1 E2F5 E2F4 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| CORUM:1473 | 5.12534978153e-05 | 0.333333333333 | E2F5 RBL2 | E2F5-RB2-DP1 complex |
| CORUM:1661 | 5.12534978153e-05 | 0.333333333333 | RBL1 E2F4 | E2F4-p107-cyclinA complex |
| REAC:R-HSA-69278 | 6.34457226533e-05 | 0.833333333333 | GMNN E2F4 RBL1 E2F5 RBL2 | Cell Cycle, Mitotic |
| REAC:R-HSA-6791312 | 9.96428056205e-05 | 0.5 | RBL1 RBL2 E2F4 | TP53 Regulates Transcription of Cell Cycle Genes |
| REAC:R-HSA-2173793 | 0.000137525924177 | 0.5 | RBL1 E2F5 E2F4 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
| CORUM:1471 | 0.000170782642132 | 0.333333333333 | E2F5 RBL2 | pRb2/p130-multimolecular complex (RB2, E2F5, HDAC1, SUV39H1, P300) |
| REAC:R-HSA-1640170 | 0.000178011057657 | 0.833333333333 | GMNN E2F4 RBL1 E2F5 RBL2 | Cell Cycle |
| KEGG:04350 | 0.000208220726788 | 0.5 | RBL1 E2F5 E2F4 | TGF-beta signaling pathway |
| CORUM:5596 | 0.00025612721106 | 0.333333333333 | RBL2 E2F4 | LINC complex, quiescent cells |
| CORUM:6444 | 0.00025612721106 | 0.333333333333 | RBL1 RBL2 | SMAR1-HDAC1-SIN3A-SIN3B-p107-p130 repressor complex |
| WP:WP236 | 0.000538725402882 | 0.5 | RBL1 RBL2 E2F4 | Adipogenesis |
| REAC:R-HSA-69202 | 0.000618329565809 | 0.5 | E2F4 E2F5 RBL2 | Cyclin E associated events during G1/S transition |
| WP:WP53 | 0.000663806947581 | 0.333333333333 | RBL1 RBL2 | ID signaling pathway |
| REAC:R-HSA-69656 | 0.000665071217307 | 0.5 | E2F4 E2F5 RBL2 | Cyclin A:Cdk2-associated events at S phase entry |
| REAC:R-HSA-170834 | 0.00073948978705 | 0.5 | RBL1 E2F5 E2F4 | Signaling by TGF-beta Receptor Complex |
| REAC:R-HSA-9006936 | 0.00141970658079 | 0.5 | RBL1 E2F5 E2F4 | Signaling by TGFB family members |
| GO:0005667 | 0.0025579351051 | 0.833333333333 | GMNN E2F4 RBL1 E2F5 RBL2 | transcription regulator complex |
| CORUM:5614 | 0.00291292900525 | 0.333333333333 | RBL1 RBL2 | Emerin complex 32 |
| GO:1990841 | 0.0136563164499 | 0.5 | RBL1 RBL2 E2F4 | promoter-specific chromatin binding |
| REAC:R-HSA-3700989 | 0.0427993747798 | 0.5 | RBL1 RBL2 E2F4 | Transcriptional Regulation by TP53 |
| CORUM:2628 | 0.0499436884912 | 0.166666666667 | CDK3 | CCNC-CDK3 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RBL1 | CDK2 | 1.0 | 0.184 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
| RBL2 | CDK2 | 1.0 | 0.126 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM |
| CDK3 | CDK2 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| RBL2 | RBL1 | 0.996 | 0.118 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM |
| GMNN | CDK2 | 0.996 | 0.193555555556 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM |
| E2F4 | GMNN | 0.974 | 0.072 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM |
| E2F4 | E2F5 | 0.974 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| GMNN | CDK3 | 0.967 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| E2F5 | CDK2 | 0.965 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| E2F4 | CDK2 | 0.962 | 0.284 | bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| GMNN | E2F5 | 0.961 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM | |
| RBL2 | CDK3 | 0.761 | bioplex_WMM bioplex3_WMM WMM_only | |
| RBL1 | CDK3 | 0.702 | bioplex_WMM bioplex3_WMM WMM_only | |
| CDK3 | E2F5 | 0.675 | bioplex3_WMM WMM_only | |
| RBL1 | GMNN | 0.638 | 0.13 | bioplex_WMM bioplex3_WMM WMM_only |
| RBL2 | GMNN | 0.625 | 0.094 | bioplex_WMM bioplex3_WMM WMM_only |
| E2F4 | RBL1 | 0.526 | 0.154 | bioplex3_WMM WMM_only |
| E2F4 | RBL2 | 0.524 | 0.09 | bioplex3_WMM WMM_only |
| RBL2 | E2F5 | 0.404 | bioplex3_WMM WMM_only | |
| RBL1 | E2F5 | 0.384 | bioplex3_WMM WMM_only | |
| E2F4 | CDK3 | 0.325 | bioplex3_WMM WMM_only |
Related Complexes