hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_03481.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PIP4K2A | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-Phosphate 4-Kinase) (PI5P4Kalpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha) | 5 | UniProt NCBI |
| MEX3B | RNA-binding protein MEX3B (RING finger and KH domain-containing protein 3) (RING finger protein 195) | 5 | UniProt NCBI |
| PIP4K2B | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta) | 5 | UniProt NCBI |
| GRM3 | Metabotropic glutamate receptor 3 (mGluR3) | 5 | UniProt NCBI |
| MEX3C | RNA-binding E3 ubiquitin-protein ligase MEX3C (EC 2.3.2.27) (RING finger and KH domain-containing protein 2) (RING finger protein 194) (RING-type E3 ubiquitin transferase MEX3C) | 5 | UniProt NCBI |
| PNISR | Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18) | 5 | UniProt NCBI |
| AHCYL1 | S-adenosylhomocysteine hydrolase-like protein 1 (DC-expressed AHCY-like molecule) (IP(3)Rs binding protein released with IP(3)) (IRBIT) (Putative adenosylhomocysteinase 2) (S-adenosyl-L-homocysteine hydrolase 2) (AdoHcyase 2) | 5 | UniProt NCBI |
| NOS1AP | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C-terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein) | 5 | UniProt NCBI |
| PLCD3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3) | 5 | UniProt NCBI |
| C1orf226 | Uncharacterized protein C1orf226 | 2 | UniProt NCBI |
| DIP2C | Disco-interacting protein 2 homolog C (DIP2 homolog C) | 3 | UniProt NCBI |
| RTF1 | RNA polymerase-associated protein RTF1 homolog | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4971 | 0.000557064052793 | 0.25 | PLCD3 PIP4K2A PIP4K2B | Phosphoinositides metabolism |
| WP:WP5411 | 0.000557064052793 | 0.25 | PLCD3 PIP4K2A PIP4K2B | Phosphatidyl inositol phosphate pathway |
| KEGG:00562 | 0.000933025920257 | 0.25 | PLCD3 PIP4K2A PIP4K2B | Inositol phosphate metabolism |
| REAC:R-HSA-8847453 | 0.0010067301791 | 0.166666666667 | PIP4K2A PIP4K2B | Synthesis of PIPs in the nucleus |
| KEGG:04070 | 0.00209033529143 | 0.25 | PLCD3 PIP4K2A PIP4K2B | Phosphatidylinositol signaling system |
| REAC:R-HSA-6811555 | 0.00602661540197 | 0.166666666667 | PIP4K2A PIP4K2B | PI5P Regulates TP53 Acetylation |
| CORUM:6371 | 0.0499436884912 | 0.0833333333333 | GRM3 | mGluR3-mGluR8 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| PIP4K2A | PIP4K2B | 1.0 | 0.318 |
| PIP4K2A | PLCD3 | 0.999 | 0.068 |
| PIP4K2A | NOS1AP | 0.997 | 0.074 |
| PIP4K2A | PNISR | 0.99 | 0.024 |
| PIP4K2A | DIP2C | 0.99 | 0.106 |
| PIP4K2A | GRM3 | 0.983 | |
| PIP4K2A | MEX3B | 0.978 | 0.098 |
| PIP4K2A | AHCYL1 | 0.974 | 0.048 |
| NOS1AP | C1orf226 | 0.973 | 0.166 |
| PIP4K2A | RTF1 | 0.973 | 0.114 |
| PIP4K2B | NOS1AP | 0.971 | 0.042 |
| PIP4K2A | MEX3C | 0.96 | 0.106 |
| PIP4K2A | C1orf226 | 0.952 | 0.104 |
| AHCYL1 | PLCD3 | 0.951 | 0.082 |
| PIP4K2B | PLCD3 | 0.95 | 0.068 |
| PLCD3 | NOS1AP | 0.948 | 0.18 |
| PLCD3 | PNISR | 0.902 | 0.066 |
| PLCD3 | DIP2C | 0.851 | 0.138 |
| PLCD3 | RTF1 | 0.83 | 0.064 |
| MEX3B | GRM3 | 0.572 | |
| GRM3 | MEX3C | 0.572 | |
| MEX3B | NOS1AP | 0.557 | 0.128 |
| GRM3 | DIP2C | 0.557 | |
| PIP4K2B | AHCYL1 | 0.552 | 0.042 |
| AHCYL1 | RTF1 | 0.512 | 0.078 |
| PNISR | GRM3 | 0.502 | |
| PIP4K2B | GRM3 | 0.333 | |
| PNISR | DIP2C | 0.333 | 0.104 |
| MEX3B | DIP2C | 0.333 | 0.098 |
| MEX3C | DIP2C | 0.333 | 0.094 |
| GRM3 | C1orf226 | 0.333 | |
| RTF1 | GRM3 | 0.303 | |
| AHCYL1 | MEX3C | 0.276 | 0.132 |
| AHCYL1 | MEX3B | 0.276 | 0.178 |
| RTF1 | DIP2C | 0.265 | 0.072 |
| PIP4K2B | DIP2C | 0.265 | 0.04 |
| MEX3B | MEX3C | 0.265 | 0.226 |
| AHCYL1 | DIP2C | 0.241 | 0.1792 |
| NOS1AP | DIP2C | 0.23 | 0.138 |
| PIP4K2B | MEX3B | 0.213 | 0.068 |
| PIP4K2B | MEX3C | 0.213 | 0.098 |
| PLCD3 | C1orf226 | 0.211 | 0.072 |
| PLCD3 | MEX3B | 0.193 | 0.116 |
| PLCD3 | MEX3C | 0.193 | 0.072 |
| AHCYL1 | NOS1AP | 0.191 | 0.16 |
| PNISR | C1orf226 | 0.189 | 0.108 |
| AHCYL1 | GRM3 | 0.18 | |
| MEX3B | PNISR | 0.172 | 0.088 |
| PNISR | MEX3C | 0.172 | 0.076 |
| PNISR | NOS1AP | 0.167 | 0.114 |
| RTF1 | MEX3C | 0.164 | 0.138 |
| C1orf226 | DIP2C | 0.164 | 0.082 |
| MEX3C | C1orf226 | 0.164 | 0.068 |
| MEX3B | C1orf226 | 0.164 | 0.056 |
| RTF1 | MEX3B | 0.164 | 0.172 |
| RTF1 | NOS1AP | 0.145 | 0.076 |
| PLCD3 | GRM3 | 0.142 | |
| MEX3C | NOS1AP | 0.14 | 0.096 |
| RTF1 | C1orf226 | 0.139 | 0.098 |
| PIP4K2B | C1orf226 | 0.131 | 0.078 |
| GRM3 | NOS1AP | 0.123 | |
| RTF1 | PNISR | 0.107 | 0.254 |
| AHCYL1 | PNISR | 0.088 | 0.032 |
| PIP4K2B | PNISR | 0.082 | 0.022 |
| AHCYL1 | C1orf226 | 0.06 | 0.092 |
| PIP4K2B | RTF1 | 0.05 | 0.03 |
Related Complexes