hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03482.1
Complex Portal: CPX-23719
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MORN3 | MORN repeat-containing protein 3 | 5 | UniProt NCBI |
| CASP7 | Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] | 5 | UniProt NCBI |
| ADAMTS4 | A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAM-TS 4) (ADAM-TS4) (ADAMTS-4) (EC 3.4.24.82) (ADMP-1) (Aggrecanase-1) | 5 | UniProt NCBI |
| XIAP | E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-111459 | 0.000102497642323 | 0.5 | CASP7 XIAP | Activation of caspases through apoptosome-mediated cleavage |
| REAC:R-HSA-111463 | 0.000153732433522 | 0.5 | CASP7 XIAP | SMAC (DIABLO) binds to IAPs |
| REAC:R-HSA-111464 | 0.000153732433522 | 0.5 | CASP7 XIAP | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes |
| REAC:R-HSA-111469 | 0.000153732433522 | 0.5 | CASP7 XIAP | SMAC, XIAP-regulated apoptotic response |
| REAC:R-HSA-111461 | 0.000676052383047 | 0.5 | CASP7 XIAP | Cytochrome c-mediated apoptotic response |
| WP:WP1433 | 0.000828175715845 | 0.5 | CASP7 XIAP | Nucleotide binding oligomerization domain NOD pathway |
| KEGG:04215 | 0.00101582950709 | 0.5 | CASP7 XIAP | Apoptosis - multiple species |
| REAC:R-HSA-111471 | 0.0013924419067 | 0.5 | CASP7 XIAP | Apoptotic factor-mediated response |
| WP:WP254 | 0.00666804419641 | 0.5 | CASP7 XIAP | Apoptosis |
| WP:WP1772 | 0.00761604886135 | 0.5 | CASP7 XIAP | Apoptosis modulation and signaling |
| WP:WP5090 | 0.00992155513194 | 0.5 | CASP7 XIAP | Complement system in neuronal development and plasticity |
| KEGG:04668 | 0.011104386562 | 0.5 | CASP7 XIAP | TNF signaling pathway |
| REAC:R-HSA-109606 | 0.0135329645116 | 0.5 | CASP7 XIAP | Intrinsic Pathway for Apoptosis |
| KEGG:04210 | 0.0177164397058 | 0.5 | CASP7 XIAP | Apoptosis |
| CORUM:6292 | 0.049938562206 | 0.25 | XIAP | HAX-1-XIAP complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| XIAP | ADAMTS4 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| CASP7 | XIAP | 0.987 | 0.21 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| MORN3 | XIAP | 0.975 | bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes