hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03484.1
Complex Portal: CPX-23053
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) | 5 | UniProt NCBI |
| SETD2 | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | 5 | UniProt NCBI |
| HSPB8 | Heat shock protein beta-8 (HspB8) (Alpha-crystallin C chain) (E2-induced gene 1 protein) (Protein kinase H11) (Small stress protein-like protein HSP22) | 5 | UniProt NCBI |
| LONRF2 | LON peptidase N-terminal domain and RING finger protein 2 (Neuroblastoma apoptosis-related protease) (RING finger protein 192) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3371571 | 0.00258893271292 | 0.5 | CAMK2B HSPB8 | HSF1-dependent transactivation |
| REAC:R-HSA-3371556 | 0.0363250695065 | 0.5 | CAMK2B HSPB8 | Cellular response to heat stress |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| SETD2 | HSPB8 | 0.987 | 0.04 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| HSPB8 | LONRF2 | 0.96 | 0.116 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CAMK2B | HSPB8 | 0.959 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SETD2 | CAMK2B | 0.134 | bioplex3_WMM gupta_WMM WMM_only | ||
| SETD2 | LONRF2 | 0.108 | 0.11 | bioplex_WMM bioplex3_WMM WMM_only | |
| CAMK2B | LONRF2 | 0.028 | bioplex3_WMM WMM_only |
Related Complexes