hu.MAP 3.0: Complex View

Genename	Protein Name	Uniprot Annotation Score	Links
PLEKHJ1	Pleckstrin homology domain-containing family J member 1 (PH domain-containing family J member 1) (Guanine nucleotide-releasing protein x)	3	UniProt NCBI
PHETA1	Sesquipedalian-1 (Ses1) (27 kDa inositol polyphosphate phosphatase-interacting protein A) (IPIP27A) (PH domain-containing endocytic trafficking adaptor 1)	5	UniProt NCBI
OCRL	Inositol polyphosphate 5-phosphatase OCRL (EC 3.1.3.36) (EC 3.1.3.56) (Inositol polyphosphate 5-phosphatase OCRL-1) (OCRL-1) (Lowe oculocerebrorenal syndrome protein) (Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase) (EC 3.1.3.86)	5	UniProt NCBI
INPP5B	Type II inositol 1,4,5-trisphosphate 5-phosphatase (EC 3.1.3.36) (75 kDa inositol polyphosphate-5-phosphatase) (Phosphoinositide 5-phosphatase) (5PTase)	5	UniProt NCBI
DENND4B	DENN domain-containing protein 4B	4	UniProt NCBI
PHETA2	Sesquipedalian-2 (Ses2) (27 kDa inositol polyphosphate phosphatase interacting protein B) (IPIP27B) (PH domain-containing endocytic trafficking adaptor 2)	5	UniProt NCBI

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-1855183	0.00170100530318	0.333333333333	OCRL INPP5B	Synthesis of IP2, IP, and Ins in the cytosol
REAC:R-HSA-1855204	0.00440152140132	0.333333333333	OCRL INPP5B	Synthesis of IP3 and IP4 in the cytosol
GO:0001881	0.0114488243093	0.5	PLEKHJ1 PHETA2 PHETA1	receptor recycling
KEGG:00562	0.0149489869659	0.333333333333	OCRL INPP5B	Inositol phosphate metabolism
REAC:R-HSA-1483249	0.019003715544	0.333333333333	OCRL INPP5B	Inositol phosphate metabolism
KEGG:04070	0.0255639626352	0.333333333333	OCRL INPP5B	Phosphatidylinositol signaling system
GO:0005802	0.0346435855588	0.666666666667	PLEKHJ1 OCRL PHETA2 PHETA1	trans-Golgi network
GO:0052658	0.042122686785	0.333333333333	OCRL INPP5B	inositol-1,4,5-trisphosphate 5-phosphatase activity
GO:0043112	0.0446883661999	0.5	PLEKHJ1 PHETA2 PHETA1	receptor metabolic process

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
INPP5B	PHETA2	1.0			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
PHETA1	OCRL	1.0			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
PLEKHJ1	PHETA1	1.0		mutually_exclusive (Q6ICB4)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
PLEKHJ1	PHETA2	1.0		structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
OCRL	PHETA2	1.0			hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
PHETA1	INPP5B	0.999			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
PLEKHJ1	OCRL	0.999	0.128		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM
OCRL	INPP5B	0.999	0.088		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
PHETA1	PHETA2	0.998		structurally_consistent (dimer)	bioplex3_WMM bioplex3_HCT116 WMM_only
PLEKHJ1	INPP5B	0.987	0.1		bioplex_WMM bioplex3_WMM WMM_only
PLEKHJ1	DENND4B	0.981	0.076		bioplex3_HEK293 bioplex3_WMM WMM_only
PHETA1	DENND4B	0.113			bioplex3_WMM WMM_only
OCRL	DENND4B	0.093	0.082		bioplex3_WMM WMM_only