hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03490.1
Complex Portal: CPX-11700
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| FEM1C | Protein fem-1 homolog C (FEM1c) (FEM1-gamma) | 5 | UniProt NCBI |
| CUL2 | Cullin-2 (CUL-2) | 5 | UniProt NCBI |
| KLHDC10 | Kelch domain-containing protein 10 | 5 | UniProt NCBI |
| RNF187 | E3 ubiquitin-protein ligase RNF187 (EC 2.3.2.27) (RING domain AP1 coactivator 1) (RACO-1) (RING finger protein 187) (RING-type E3 ubiquitin transferase RNF187) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0140627 | 6.34131776058e-05 | 0.75 | FEM1C KLHDC10 CUL2 | ubiquitin-dependent protein catabolic process via the C-end degron rule pathway |
| GO:0031462 | 0.000510886175237 | 0.75 | FEM1C KLHDC10 CUL2 | Cul2-RING ubiquitin ligase complex |
| GO:0043161 | 0.0132396737881 | 1.0 | RNF187 FEM1C KLHDC10 CUL2 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| CORUM:6736 | 0.0249718442456 | 0.25 | CUL2 | PRAME-Cullin2 ubiquitin ligase complex |
| GO:0010498 | 0.0346048712992 | 1.0 | RNF187 FEM1C KLHDC10 CUL2 | proteasomal protein catabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RNF187 | CUL2 | 0.994 | 0.156 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FEM1C | CUL2 | 0.99 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| KLHDC10 | CUL2 | 0.967 | 0.06 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM WMM_only | |
| RNF187 | FEM1C | 0.726 | bioplex_WMM bioplex3_WMM WMM_only | ||
| KLHDC10 | FEM1C | 0.53 | bioplex_WMM bioplex3_WMM WMM_only | ||
| KLHDC10 | RNF187 | 0.269 | 0.132 | bioplex3_WMM WMM_only |
Related Complexes