hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03497.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ALG8 | Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase (EC 2.4.1.265) (Asparagine-linked glycosylation protein 8 homolog) (Dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1,3-glucosyltransferase) (Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase) | 5 | UniProt NCBI |
| ALG6 | Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase (EC 2.4.1.267) (Asparagine-linked glycosylation protein 6 homolog) (Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase) (Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4521 | 0.000107686165619 | 1.0 | ALG8 ALG6 | Glycosylation and related congenital defects |
| HP:0005543 | 0.000123030846153 | 1.0 | ALG8 ALG6 | Reduced protein C activity |
| KEGG:00510 | 0.000183378615366 | 1.0 | ALG8 ALG6 | N-Glycan biosynthesis |
| HP:0030780 | 0.000225556551281 | 1.0 | ALG8 ALG6 | Abnormality of the protein C anticoagulant pathway |
| HP:0001929 | 0.000225556551281 | 1.0 | ALG8 ALG6 | Reduced factor XI activity |
| HP:0001976 | 0.000266566833332 | 1.0 | ALG8 ALG6 | Reduced antithrombin III activity |
| REAC:R-HSA-3781860 | 0.000324664732905 | 1.0 | ALG8 ALG6 | Diseases associated with N-glycosylation of proteins |
| HP:0010988 | 0.000358839967947 | 1.0 | ALG8 ALG6 | Abnormality of the extrinsic pathway |
| HP:0002243 | 0.000464783196579 | 1.0 | ALG8 ALG6 | Protein-losing enteropathy |
| GO:0004583 | 0.000468200720083 | 1.0 | ALG8 ALG6 | dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity |
| WP:WP5153 | 0.000542687198278 | 1.0 | ALG8 ALG6 | N glycan biosynthesis |
| HP:0003642 | 0.000584396519228 | 1.0 | ALG8 ALG6 | Type I transferrin isoform profile |
| HP:0010989 | 0.00158914842948 | 1.0 | ALG8 ALG6 | Abnormality of the intrinsic pathway |
| HP:0003160 | 0.00266566833332 | 1.0 | ALG8 ALG6 | Abnormal isoelectric focusing of serum transferrin |
| HP:0012347 | 0.00294248773717 | 1.0 | ALG8 ALG6 | Abnormal protein N-linked glycosylation |
| HP:0012346 | 0.00308602372434 | 1.0 | ALG8 ALG6 | Abnormal protein glycosylation |
| HP:0012345 | 0.0038549665128 | 1.0 | ALG8 ALG6 | Abnormal glycosylation |
| REAC:R-HSA-446193 | 0.00449062588459 | 1.0 | ALG8 ALG6 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| REAC:R-HSA-3781865 | 0.0106216630512 | 1.0 | ALG8 ALG6 | Diseases of glycosylation |
| HP:0012116 | 0.0159119894358 | 1.0 | ALG8 ALG6 | Abnormal circulating albumin concentration |
| HP:0003073 | 0.0159119894358 | 1.0 | ALG8 ALG6 | Hypoalbuminemia |
| REAC:R-HSA-4724289 | 0.0249718442457 | 0.5 | ALG6 | Defective ALG6 causes CDG-1c |
| REAC:R-HSA-4724325 | 0.0249718442457 | 0.5 | ALG8 | Defective ALG8 causes CDG-1h |
| HP:0003256 | 0.0252247409849 | 1.0 | ALG8 ALG6 | Abnormality of the coagulation cascade |
| HP:0000158 | 0.026912997596 | 1.0 | ALG8 ALG6 | Macroglossia |
| HP:0032245 | 0.0291002126388 | 1.0 | ALG8 ALG6 | Abnormal metabolism |
| REAC:R-HSA-5668914 | 0.0297170756313 | 1.0 | ALG8 ALG6 | Diseases of metabolism |
| GO:0006488 | 0.0491610756088 | 1.0 | ALG8 ALG6 | dolichol-linked oligosaccharide biosynthetic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ALG6 | ALG8 | 0.997 | 0.22 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| ALG8 | huMAP3_03497.1 huMAP3_07262.1 huMAP3_09877.1 huMAP3_15312.1 |
| ALG6 | huMAP3_00455.1 huMAP3_00859.1 huMAP3_03497.1 huMAP3_05559.1 huMAP3_07952.1 huMAP3_09877.1 |