hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_03518.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CREB3L3 | Cyclic AMP-responsive element-binding protein 3-like protein 3 (cAMP-responsive element-binding protein 3-like protein 3) (Transcription factor CREB-H) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 3] | 5 | UniProt NCBI |
| CREB3 | Cyclic AMP-responsive element-binding protein 3 (CREB-3) (cAMP-responsive element-binding protein 3) (Leucine zipper protein) (Luman) (Transcription factor LZIP-alpha) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3 (N-terminal Luman) (Transcriptionally active form)] | 5 | UniProt NCBI |
| CREB3L4 | Cyclic AMP-responsive element-binding protein 3-like protein 4 (cAMP-responsive element-binding protein 3-like protein 4) (Androgen-induced basic leucine zipper protein) (AIbZIP) (Attaching to CRE-like 1) (ATCE1) (Cyclic AMP-responsive element-binding protein 4) (CREB-4) (cAMP-responsive element-binding protein 4) (Transcript induced in spermiogenesis protein 40) (Tisp40) (hJAL) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 4] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8874211 | 1.63310749402e-08 | 1.0 | CREB3 CREB3L3 CREB3L4 | CREB3 factors activate genes |
| WP:WP5272 | 7.51131611315e-08 | 1.0 | CREB3 CREB3L3 CREB3L4 | LDL influence on CD14 and TLR4 |
| WP:WP4756 | 4.63856714356e-07 | 1.0 | CREB3 CREB3L3 CREB3L4 | Renin angiotensin aldosterone system RAAS |
| KEGG:04962 | 5.16122829258e-07 | 1.0 | CREB3 CREB3L3 CREB3L4 | Vasopressin-regulated water reabsorption |
| KEGG:05030 | 5.5686936841e-07 | 1.0 | CREB3 CREB3L3 CREB3L4 | Cocaine addiction |
| KEGG:04927 | 5.99705473673e-07 | 1.0 | CREB3 CREB3L3 CREB3L4 | Cortisol synthesis and secretion |
| WP:WP5085 | 7.65859682125e-07 | 1.0 | CREB3 CREB3L3 CREB3L4 | Vasopressin regulated water reabsorption |
| KEGG:05031 | 1.52851760973e-06 | 1.0 | CREB3 CREB3L3 CREB3L4 | Amphetamine addiction |
| KEGG:04918 | 1.78762380741e-06 | 1.0 | CREB3 CREB3L3 CREB3L4 | Thyroid hormone synthesis |
| KEGG:04911 | 2.28180619251e-06 | 1.0 | CREB3 CREB3L3 CREB3L4 | Insulin secretion |
| WP:WP45 | 3.22963338017e-06 | 1.0 | CREB3 CREB3L3 CREB3L4 | G1 to S cell cycle control |
| KEGG:04925 | 3.38635083845e-06 | 1.0 | CREB3 CREB3L3 CREB3L4 | Aldosterone synthesis and secretion |
| KEGG:04211 | 4.45704451339e-06 | 1.0 | CREB3 CREB3L3 CREB3L4 | Longevity regulating pathway |
| KEGG:04916 | 4.79978559464e-06 | 1.0 | CREB3 CREB3L3 CREB3L4 | Melanogenesis |
| KEGG:04928 | 4.79978559464e-06 | 1.0 | CREB3 CREB3L3 CREB3L4 | Parathyroid hormone synthesis, secretion and action |
| KEGG:04725 | 5.93248714392e-06 | 1.0 | CREB3 CREB3L3 CREB3L4 | Cholinergic synapse |
| KEGG:05215 | 6.13705566612e-06 | 1.0 | CREB3 CREB3L3 CREB3L4 | Prostate cancer |
| KEGG:04915 | 6.56019280347e-06 | 1.0 | CREB3 CREB3L3 CREB3L4 | Estrogen signaling pathway |
| KEGG:04922 | 6.56019280347e-06 | 1.0 | CREB3 CREB3L3 CREB3L4 | Glucagon signaling pathway |
| KEGG:04668 | 7.23068232913e-06 | 1.0 | CREB3 CREB3L3 CREB3L4 | TNF signaling pathway |
| KEGG:04931 | 7.94536617802e-06 | 1.0 | CREB3 CREB3L3 CREB3L4 | Insulin resistance |
| KEGG:04935 | 8.44707100112e-06 | 1.0 | CREB3 CREB3L3 CREB3L4 | Growth hormone synthesis, secretion and action |
| WP:WP4321 | 9.41705095982e-06 | 1.0 | CREB3 CREB3L3 CREB3L4 | Thermogenesis |
| KEGG:04926 | 1.06649364707e-05 | 1.0 | CREB3 CREB3L3 CREB3L4 | Relaxin signaling pathway |
| KEGG:04728 | 1.09667742953e-05 | 1.0 | CREB3 CREB3L3 CREB3L4 | Dopaminergic synapse |
| KEGG:04152 | 1.22310662704e-05 | 1.0 | CREB3 CREB3L3 CREB3L4 | AMPK signaling pathway |
| KEGG:04261 | 1.43040725693e-05 | 1.0 | CREB3 CREB3L3 CREB3L4 | Adrenergic signaling in cardiomyocytes |
| KEGG:04022 | 1.65989907892e-05 | 1.0 | CREB3 CREB3L3 CREB3L4 | cGMP-PKG signaling pathway |
| KEGG:04934 | 1.65989907892e-05 | 1.0 | CREB3 CREB3L3 CREB3L4 | Cushing syndrome |
| KEGG:05161 | 2.7655198514e-05 | 1.0 | CREB3 CREB3L3 CREB3L4 | Hepatitis B |
| KEGG:05034 | 2.82234560177e-05 | 1.0 | CREB3 CREB3L3 CREB3L4 | Alcoholism |
| WP:WP4666 | 3.24963255001e-05 | 1.0 | CREB3 CREB3L3 CREB3L4 | Hepatitis B infection |
| KEGG:04024 | 3.36919550068e-05 | 1.0 | CREB3 CREB3L3 CREB3L4 | cAMP signaling pathway |
| KEGG:05207 | 3.7014626318e-05 | 1.0 | CREB3 CREB3L3 CREB3L4 | Chemical carcinogenesis - receptor activation |
| REAC:R-HSA-381119 | 4.44597184171e-05 | 1.0 | CREB3 CREB3L3 CREB3L4 | Unfolded Protein Response (UPR) |
| KEGG:05203 | 5.51248435573e-05 | 1.0 | CREB3 CREB3L3 CREB3L4 | Viral carcinogenesis |
| KEGG:05163 | 6.06642833159e-05 | 1.0 | CREB3 CREB3L3 CREB3L4 | Human cytomegalovirus infection |
| KEGG:05166 | 6.65629194888e-05 | 1.0 | CREB3 CREB3L3 CREB3L4 | Human T-cell leukemia virus 1 infection |
| KEGG:04714 | 7.39136996301e-05 | 1.0 | CREB3 CREB3L3 CREB3L4 | Thermogenesis |
| KEGG:05020 | 0.000126475690353 | 1.0 | CREB3 CREB3L3 CREB3L4 | Prion disease |
| KEGG:05016 | 0.000171368189864 | 1.0 | CREB3 CREB3L3 CREB3L4 | Huntington disease |
| WP:WP3932 | 0.000194681531196 | 1.0 | CREB3 CREB3L3 CREB3L4 | Focal adhesion PI3K Akt mTOR signaling pathway |
| KEGG:04151 | 0.000201545964825 | 1.0 | CREB3 CREB3L3 CREB3L4 | PI3K-Akt signaling pathway |
| KEGG:05165 | 0.000218999274719 | 1.0 | CREB3 CREB3L3 CREB3L4 | Human papillomavirus infection |
| WP:WP4172 | 0.000254288281733 | 1.0 | CREB3 CREB3L3 CREB3L4 | PI3K Akt signaling pathway |
| REAC:R-HSA-2262752 | 0.0292688889279 | 1.0 | CREB3 CREB3L3 CREB3L4 | Cellular responses to stress |
| REAC:R-HSA-8953897 | 0.0301284815898 | 1.0 | CREB3 CREB3L3 CREB3L4 | Cellular responses to stimuli |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CREB3L3 | CREB3 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CREB3L3 | CREB3L4 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CREB3 | CREB3L4 | 0.977 | bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes