hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03520.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SIK3 | Serine/threonine-protein kinase SIK3 (EC 2.7.11.1) (Salt-inducible kinase 3) (SIK-3) (Serine/threonine-protein kinase QSK) | 5 | UniProt NCBI |
| NFATC1 | Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1) (NFATc1) (NFAT transcription complex cytosolic component) (NF-ATc) (NFATc) | 5 | UniProt NCBI |
| PPP3R2 | Calcineurin subunit B type 2 (Calcineurin B-like protein) (CBLP) (Calcineurin BII) (CNBII) (PPP3R1-like) (Protein phosphatase 2B regulatory subunit 2) (Protein phosphatase 3 regulatory subunit B beta isoform) | 5 | UniProt NCBI |
| NFATC3 | Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (NFATx) (T-cell transcription factor NFAT4) (NF-AT4) (NF-AT4c) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3414 | 1.27546878771e-06 | 0.75 | NFATC1 NFATC3 PPP3R2 | Initiation of transcription and translation elongation at the HIV 1 LTR |
| KEGG:04662 | 1.71467161414e-05 | 0.75 | NFATC1 NFATC3 PPP3R2 | B cell receptor signaling pathway |
| KEGG:04658 | 2.21720662311e-05 | 0.75 | NFATC1 NFATC3 PPP3R2 | Th1 and Th2 cell differentiation |
| KEGG:05235 | 2.80928961665e-05 | 0.75 | NFATC1 NFATC3 PPP3R2 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| KEGG:04625 | 3.37636371132e-05 | 0.75 | NFATC1 NFATC3 PPP3R2 | C-type lectin receptor signaling pathway |
| KEGG:04659 | 4.01491324891e-05 | 0.75 | NFATC1 NFATC3 PPP3R2 | Th17 cell differentiation |
| WP:WP428 | 5.79557471679e-05 | 0.75 | NFATC1 NFATC3 PPP3R2 | Wnt signaling |
| KEGG:04660 | 6.03988351827e-05 | 0.75 | NFATC1 NFATC3 PPP3R2 | T cell receptor signaling pathway |
| KEGG:04921 | 9.10876349728e-05 | 0.75 | NFATC1 NFATC3 PPP3R2 | Oxytocin signaling pathway |
| KEGG:04022 | 0.000108396031683 | 0.75 | NFATC1 NFATC3 PPP3R2 | cGMP-PKG signaling pathway |
| KEGG:04218 | 0.000152567450385 | 0.75 | NFATC1 NFATC3 PPP3R2 | Cellular senescence |
| KEGG:04310 | 0.00018782554568 | 0.75 | NFATC1 NFATC3 PPP3R2 | Wnt signaling pathway |
| REAC:R-HSA-2025928 | 0.000215205765992 | 0.5 | NFATC1 NFATC3 | Calcineurin activates NFAT |
| KEGG:05167 | 0.000264207276718 | 0.75 | NFATC1 NFATC3 PPP3R2 | Kaposi sarcoma-associated herpesvirus infection |
| KEGG:04020 | 0.000283592326998 | 0.75 | NFATC1 NFATC3 PPP3R2 | Calcium signaling pathway |
| KEGG:05417 | 0.000325152133201 | 0.75 | NFATC1 NFATC3 PPP3R2 | Lipid and atherosclerosis |
| REAC:R-HSA-5607763 | 0.000368856835097 | 0.5 | NFATC1 NFATC3 | CLEC7A (Dectin-1) induces NFAT activation |
| KEGG:05163 | 0.000394783718861 | 0.75 | NFATC1 NFATC3 PPP3R2 | Human cytomegalovirus infection |
| KEGG:05170 | 0.00040099636109 | 0.75 | NFATC1 NFATC3 PPP3R2 | Human immunodeficiency virus 1 infection |
| KEGG:05166 | 0.000433035444638 | 0.75 | NFATC1 NFATC3 PPP3R2 | Human T-cell leukemia virus 1 infection |
| WP:WP4585 | 0.000436026474737 | 0.5 | NFATC1 NFATC3 | Cancer immunotherapy by PD 1 blockade |
| WP:WP382 | 0.000461288756706 | 0.75 | NFATC1 NFATC3 PPP3R2 | MAPK signaling pathway |
| KEGG:04010 | 0.000800866642312 | 0.75 | NFATC1 NFATC3 PPP3R2 | MAPK signaling pathway |
| WP:WP1591 | 0.00142851438729 | 0.5 | NFATC1 NFATC3 | Heart development |
| REAC:R-HSA-2871809 | 0.00175047124894 | 0.5 | NFATC1 NFATC3 | FCERI mediated Ca+2 mobilization |
| GO:0033173 | 0.00209449363787 | 0.75 | NFATC1 NFATC3 PPP3R2 | calcineurin-NFAT signaling cascade |
| GO:0097720 | 0.00229706847948 | 0.75 | NFATC1 NFATC3 PPP3R2 | calcineurin-mediated signaling |
| KEGG:04650 | 0.014619629343 | 0.5 | NFATC1 PPP3R2 | Natural killer cell mediated cytotoxicity |
| KEGG:04380 | 0.0162723391924 | 0.5 | NFATC1 PPP3R2 | Osteoclast differentiation |
| KEGG:05135 | 0.0162723391924 | 0.5 | NFATC1 NFATC3 | Yersinia infection |
| KEGG:04148 | 0.0189154103852 | 0.5 | NFATC1 NFATC3 | Efferocytosis |
| WP:WP4666 | 0.023499356813 | 0.5 | NFATC1 NFATC3 | Hepatitis B infection |
| KEGG:05161 | 0.0269222811984 | 0.5 | NFATC1 NFATC3 | Hepatitis B |
| REAC:R-HSA-1168372 | 0.0275106007785 | 0.5 | NFATC1 NFATC3 | Downstream signaling events of B Cell Receptor (BCR) |
| KEGG:04360 | 0.0291410886797 | 0.5 | PPP3R2 NFATC3 | Axon guidance |
| REAC:R-HSA-5607764 | 0.0407325822829 | 0.5 | NFATC1 NFATC3 | CLEC7A (Dectin-1) signaling |
| REAC:R-HSA-983705 | 0.046351696636 | 0.5 | NFATC1 NFATC3 | Signaling by the B Cell Receptor (BCR) |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SIK3 | PPP3R2 | 0.998 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| NFATC1 | PPP3R2 | 0.996 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PPP3R2 | NFATC3 | 0.996 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SIK3 | NFATC1 | 0.922 | 0.052 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| NFATC1 | NFATC3 | 0.904 | 0.112 | bioplex3_WMM WMM_only |
| SIK3 | NFATC3 | 0.892 | 0.094 | bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| SIK3 | huMAP3_03520.1 huMAP3_07944.1 huMAP3_10807.1 huMAP3_15008.1 |
| NFATC1 | huMAP3_03520.1 huMAP3_07944.1 huMAP3_10807.1 huMAP3_15008.1 |
| PPP3R2 | huMAP3_03520.1 huMAP3_08071.1 huMAP3_10807.1 huMAP3_15008.1 |
| NFATC3 | huMAP3_03520.1 huMAP3_08071.1 huMAP3_10807.1 huMAP3_15008.1 |