hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03523.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UGT1A10 | UDP-glucuronosyltransferase 1A10 (UGT1A10) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-10) (UDPGT 1-10) (UGT1*10) (UGT1-10) (UGT1.10) (UDP-glucuronosyltransferase 1-J) (UGT-1J) (UGT1J) | 5 | UniProt NCBI |
| UGT1A8 | UDP-glucuronosyltransferase 1A8 (UGT1A8) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-8) (UDPGT 1-8) (UGT1*8) (UGT1-08) (UGT1.8) (UDP-glucuronosyltransferase 1-H) (UGT-1H) (UGT1H) | 5 | UniProt NCBI |
| UGT1A7 | UDP-glucuronosyltransferase 1A7 (UGT1A7) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-7) (UDPGT 1-7) (UGT1*7) (UGT1-07) (UGT1.7) (UDP-glucuronosyltransferase 1-G) (UGT-1G) (UGT1G) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP698 | 6.32531883213e-08 | 1.0 | UGT1A8 UGT1A10 UGT1A7 | Glucuronidation |
| KEGG:00053 | 8.04482952488e-08 | 1.0 | UGT1A8 UGT1A10 UGT1A7 | Ascorbate and aldarate metabolism |
| KEGG:00040 | 1.20150051346e-07 | 1.0 | UGT1A8 UGT1A10 UGT1A7 | Pentose and glucuronate interconversions |
| REAC:R-HSA-156588 | 2.61297199043e-07 | 1.0 | UGT1A8 UGT1A10 UGT1A7 | Glucuronidation |
| KEGG:00860 | 2.85016817453e-07 | 1.0 | UGT1A8 UGT1A10 UGT1A7 | Porphyrin metabolism |
| GO:0051552 | 3.84480164306e-07 | 1.0 | UGT1A8 UGT1A10 UGT1A7 | flavone metabolic process |
| KEGG:00140 | 5.16122829258e-07 | 1.0 | UGT1A8 UGT1A10 UGT1A7 | Steroid hormone biosynthesis |
| KEGG:00830 | 1.0878803562e-06 | 1.0 | UGT1A8 UGT1A10 UGT1A7 | Retinol metabolism |
| KEGG:05204 | 1.22375439253e-06 | 1.0 | UGT1A8 UGT1A10 UGT1A7 | Chemical carcinogenesis - DNA adducts |
| KEGG:00982 | 1.29573994503e-06 | 1.0 | UGT1A8 UGT1A10 UGT1A7 | Drug metabolism - cytochrome P450 |
| KEGG:04976 | 1.61189129753e-06 | 1.0 | UGT1A8 UGT1A10 UGT1A7 | Bile secretion |
| KEGG:00980 | 1.69824261704e-06 | 1.0 | UGT1A8 UGT1A10 UGT1A7 | Metabolism of xenobiotics by cytochrome P450 |
| KEGG:00983 | 2.50251661292e-06 | 1.0 | UGT1A8 UGT1A10 UGT1A7 | Drug metabolism - other enzymes |
| GO:0009812 | 3.36420143768e-06 | 1.0 | UGT1A8 UGT1A10 UGT1A7 | flavonoid metabolic process |
| WP:WP5224 | 1.45311797582e-05 | 1.0 | UGT1A8 UGT1A10 UGT1A7 | 2q37 copy number variation syndrome |
| KEGG:01240 | 2.04821359703e-05 | 1.0 | UGT1A8 UGT1A10 UGT1A7 | Biosynthesis of cofactors |
| GO:0052695 | 3.49876949518e-05 | 1.0 | UGT1A8 UGT1A10 UGT1A7 | cellular glucuronidation |
| KEGG:05207 | 3.7014626318e-05 | 1.0 | UGT1A8 UGT1A10 UGT1A7 | Chemical carcinogenesis - receptor activation |
| REAC:R-HSA-156580 | 3.83360319167e-05 | 1.0 | UGT1A8 UGT1A10 UGT1A7 | Phase II - Conjugation of compounds |
| REAC:R-HSA-9748784 | 3.98104946827e-05 | 1.0 | UGT1A8 UGT1A10 UGT1A7 | Drug ADME |
| GO:0006063 | 4.37346186898e-05 | 1.0 | UGT1A8 UGT1A10 UGT1A7 | uronic acid metabolic process |
| GO:0019585 | 4.37346186898e-05 | 1.0 | UGT1A8 UGT1A10 UGT1A7 | glucuronate metabolic process |
| WP:WP1604 | 5.0954861614e-05 | 0.666666666667 | UGT1A8 UGT1A10 | Codeine and morphine metabolism |
| WP:WP691 | 0.000103023242897 | 0.666666666667 | UGT1A8 UGT1A10 | Tamoxifen metabolism |
| GO:0015020 | 0.000194546963139 | 1.0 | UGT1A8 UGT1A10 UGT1A7 | glucuronosyltransferase activity |
| WP:WP5276 | 0.000237669979309 | 0.666666666667 | UGT1A8 UGT1A10 | Estrogen metabolism |
| REAC:R-HSA-211859 | 0.000330616079734 | 1.0 | UGT1A8 UGT1A10 UGT1A7 | Biological oxidations |
| GO:0001889 | 0.000746852719164 | 1.0 | UGT1A8 UGT1A10 UGT1A7 | liver development |
| GO:0061008 | 0.000810868666521 | 1.0 | UGT1A8 UGT1A10 UGT1A7 | hepaticobiliary system development |
| GO:0042440 | 0.00200169985542 | 1.0 | UGT1A8 UGT1A10 UGT1A7 | pigment metabolic process |
| REAC:R-HSA-9749641 | 0.00296224002415 | 0.666666666667 | UGT1A8 UGT1A7 | Aspirin ADME |
| GO:0052696 | 0.00842684400117 | 0.666666666667 | UGT1A8 UGT1A7 | flavonoid glucuronidation |
| WP:WP702 | 0.0101834993772 | 0.666666666667 | UGT1A7 UGT1A10 | Metapathway biotransformation Phase I and II |
| GO:0006805 | 0.0101882437539 | 1.0 | UGT1A8 UGT1A10 UGT1A7 | xenobiotic metabolic process |
| GO:0009804 | 0.0140440992017 | 0.666666666667 | UGT1A8 UGT1A7 | coumarin metabolic process |
| GO:0009698 | 0.0140440992017 | 0.666666666667 | UGT1A8 UGT1A7 | phenylpropanoid metabolic process |
| KEGG:01100 | 0.0189521995452 | 1.0 | UGT1A8 UGT1A10 UGT1A7 | Metabolic pathways |
| GO:0071466 | 0.0201788647033 | 1.0 | UGT1A8 UGT1A10 UGT1A7 | cellular response to xenobiotic stimulus |
| GO:0052697 | 0.0210651876021 | 0.666666666667 | UGT1A8 UGT1A7 | xenobiotic glucuronidation |
| GO:0048732 | 0.0225051619375 | 1.0 | UGT1A8 UGT1A10 UGT1A7 | gland development |
| GO:0008194 | 0.023732518742 | 1.0 | UGT1A8 UGT1A10 UGT1A7 | UDP-glycosyltransferase activity |
| GO:0009410 | 0.0439566559847 | 1.0 | UGT1A8 UGT1A10 UGT1A7 | response to xenobiotic stimulus |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| UGT1A7 | UGT1A10 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| UGT1A8 | UGT1A7 | 0.972 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| UGT1A8 | UGT1A10 | 0.415 | bioplex3_WMM WMM_only |
Related Complexes