hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03530.1
Complex Portal: CPX-23841
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NPRL2 | GATOR1 complex protein NPRL2 (Gene 21 protein) (G21 protein) (Nitrogen permease regulator 2-like protein) (NPR2-like protein) (Tumor suppressor candidate 4) | 5 | UniProt NCBI |
| OGA | Protein O-GlcNAcase (OGA) (EC 3.2.1.169) (Beta-N-acetylglucosaminidase) (Beta-N-acetylhexosaminidase) (Beta-hexosaminidase) (Meningioma-expressed antigen 5) (N-acetyl-beta-D-glucosaminidase) (N-acetyl-beta-glucosaminidase) (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) (NCOAT) | 5 | UniProt NCBI |
| BMT2 | S-adenosylmethionine sensor upstream of mTORC1 (Probable methyltransferase BMT2 homolog) (EC 2.1.1.-) | 5 | UniProt NCBI |
| DEPDC5 | GATOR1 complex protein DEPDC5 (DEP domain-containing protein 5) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6215 | 1.53774525569e-05 | 0.5 | DEPDC5 NPRL2 | GATOR1 complex |
| REAC:R-HSA-9639288 | 3.27872895639e-05 | 0.75 | DEPDC5 NPRL2 BMT2 | Amino acids regulate mTORC1 |
| CORUM:6217 | 0.000143457417375 | 0.5 | DEPDC5 NPRL2 | GATOR complex |
| HP:0012005 | 0.000501460556964 | 0.5 | DEPDC5 NPRL2 | Deja vu aura |
| HP:0012004 | 0.000501460556964 | 0.5 | DEPDC5 NPRL2 | Focal cognitive seizure with deja vu/jamais vu |
| HP:0032680 | 0.000501460556964 | 0.5 | DEPDC5 NPRL2 | Focal cognitive seizure |
| HP:0008765 | 0.000701980712879 | 0.5 | DEPDC5 NPRL2 | Auditory hallucination |
| REAC:R-HSA-9711097 | 0.00081494341463 | 0.75 | DEPDC5 NPRL2 BMT2 | Cellular response to starvation |
| HP:0033346 | 0.00120317586686 | 0.5 | DEPDC5 NPRL2 | Psychic epileptic aura |
| HP:0012002 | 0.00120317586686 | 0.5 | DEPDC5 NPRL2 | Experiential epileptic aura |
| HP:0002427 | 0.00183784982408 | 0.5 | DEPDC5 NPRL2 | Expressive aphasia |
| HP:0032046 | 0.00303997345979 | 0.5 | DEPDC5 NPRL2 | Focal cortical dysplasia |
| HP:0007206 | 0.00303997345979 | 0.5 | DEPDC5 NPRL2 | Hemimegalencephaly |
| HP:0031951 | 0.00303997345979 | 0.5 | DEPDC5 NPRL2 | Nocturnal seizures |
| HP:0002367 | 0.00350734148159 | 0.5 | DEPDC5 NPRL2 | Visual hallucination |
| GO:1904262 | 0.00440499676786 | 0.75 | DEPDC5 NPRL2 BMT2 | negative regulation of TORC1 signaling |
| GO:0034198 | 0.00473512798232 | 0.75 | DEPDC5 NPRL2 BMT2 | cellular response to amino acid starvation |
| GO:1990928 | 0.00544401218013 | 0.75 | DEPDC5 NPRL2 BMT2 | response to amino acid starvation |
| HP:0033348 | 0.0057098705025 | 0.5 | DEPDC5 NPRL2 | Epileptic aura |
| HP:0011171 | 0.00701084122037 | 0.5 | DEPDC5 NPRL2 | Simple febrile seizure |
| HP:0002349 | 0.00701084122037 | 0.5 | DEPDC5 NPRL2 | Focal aware seizure |
| GO:0032007 | 0.0124631389739 | 0.75 | DEPDC5 NPRL2 BMT2 | negative regulation of TOR signaling |
| WP:WP4657 | 0.0125286636678 | 0.5 | DEPDC5 NPRL2 | 22q11 2 copy number variation syndrome |
| HP:0032679 | 0.018706736024 | 0.5 | DEPDC5 NPRL2 | Focal non-motor seizure |
| HP:0001355 | 0.0222019103471 | 0.5 | DEPDC5 NPRL2 | Megalencephaly |
| KEGG:04150 | 0.0269222811984 | 0.5 | DEPDC5 NPRL2 | mTOR signaling pathway |
| GO:1990130 | 0.0280843539964 | 0.5 | DEPDC5 NPRL2 | GATOR1 complex |
| HP:0031284 | 0.0315158796726 | 0.5 | DEPDC5 NPRL2 | Flushing |
| GO:1903432 | 0.0378152735667 | 0.75 | DEPDC5 NPRL2 BMT2 | regulation of TORC1 signaling |
| HP:0002539 | 0.0424493051949 | 0.5 | DEPDC5 NPRL2 | Cortical dysplasia |
| GO:0038202 | 0.0434703685672 | 0.75 | DEPDC5 NPRL2 BMT2 | TORC1 signaling |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| NPRL2 | DEPDC5 | 1.0 | 0.138 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| BMT2 | DEPDC5 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| NPRL2 | BMT2 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| OGA | BMT2 | 0.982 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| OGA | DEPDC5 | 0.345 | 0.074 | bioplex_WMM bioplex3_WMM WMM_only | |
| NPRL2 | OGA | 0.254 | 0.05 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes