hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_03536.1

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
AP3B1	AP-3 complex subunit beta-1 (Adaptor protein complex AP-3 subunit beta-1) (Adaptor-related protein complex 3 subunit beta-1) (Beta-3A-adaptin) (Clathrin assembly protein complex 3 beta-1 large chain)	5	UniProt NCBI
RNF167	E3 ubiquitin-protein ligase RNF167 (EC 2.3.2.27) (RING finger protein 167)	5	UniProt NCBI
AP3S1	AP-3 complex subunit sigma-1 (AP-3 complex subunit sigma-3A) (Adaptor-related protein complex 3 subunit sigma-1) (Clathrin-associated/assembly/adaptor protein, small 3) (Sigma-3A-adaptin) (Sigma3A-adaptin) (Sigma-adaptin 3a)	5	UniProt NCBI
AP3D1	AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adaptor-related protein complex 3 subunit delta-1) (Delta-adaptin)	5	UniProt NCBI
AP3B2	AP-3 complex subunit beta-2 (Adaptor protein complex AP-3 subunit beta-2) (Adaptor-related protein complex 3 subunit beta-2) (Beta-3B-adaptin) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:59	1.34226065824e-11	0.8	AP3B2 AP3B1 AP3S1 AP3D1	AP3 adaptor complex
CORUM:652	5.23252320392e-10	0.8	AP3B2 AP3B1 AP3S1 AP3D1	AP3-BLOC1 complex
GO:0035654	4.60395405777e-09	0.8	AP3B2 AP3B1 AP3S1 AP3D1	clathrin-coated vesicle cargo loading, AP-3-mediated
GO:0035652	4.60395405777e-09	0.8	AP3B2 AP3B1 AP3S1 AP3D1	clathrin-coated vesicle cargo loading
GO:0030123	1.65724193228e-08	0.8	AP3B2 AP3B1 AP3S1 AP3D1	AP-3 adaptor complex
GO:0048490	4.02274655956e-07	0.8	AP3B2 AP3B1 AP3S1 AP3D1	anterograde synaptic vesicle transport
GO:0099517	4.02274655956e-07	0.8	AP3B2 AP3B1 AP3S1 AP3D1	synaptic vesicle transport along microtubule
GO:0099514	4.02274655956e-07	0.8	AP3B2 AP3B1 AP3S1 AP3D1	synaptic vesicle cytoskeletal transport
KEGG:04142	1.15206877781e-06	0.8	AP3B2 AP3B1 AP3S1 AP3D1	Lysosome
GO:0035459	4.13351489328e-06	0.8	AP3B2 AP3B1 AP3S1 AP3D1	vesicle cargo loading
GO:0048489	4.72375798258e-06	0.8	AP3B2 AP3B1 AP3S1 AP3D1	synaptic vesicle transport
WP:WP5408	5.97157271838e-06	0.6	AP3B2 AP3S1 AP3D1	15q25 copy number variation
GO:0030119	6.87695434453e-06	0.8	AP3B2 AP3B1 AP3S1 AP3D1	AP-type membrane coat adaptor complex
GO:0097479	8.67338862712e-06	0.8	AP3B2 AP3B1 AP3S1 AP3D1	synaptic vesicle localization
GO:0016183	9.61003071434e-06	0.6	AP3B2 AP3S1 AP3D1	synaptic vesicle coating
GO:0047496	1.32964092214e-05	0.8	AP3B2 AP3B1 AP3S1 AP3D1	vesicle transport along microtubule
CORUM:2308	1.36501667663e-05	0.4	AP3S1 AP3D1	AP3D1-AP3S1 complex
GO:0008089	1.46952249556e-05	0.8	AP3B2 AP3B1 AP3S1 AP3D1	anterograde axonal transport
GO:0070142	3.362820138e-05	0.6	AP3B2 AP3S1 AP3D1	synaptic vesicle budding
GO:0016185	3.362820138e-05	0.6	AP3B2 AP3S1 AP3D1	synaptic vesicle budding from presynaptic endocytic zone membrane
GO:0098930	4.14930734417e-05	0.8	AP3B2 AP3B1 AP3S1 AP3D1	axonal transport
GO:0008088	6.39580887555e-05	0.8	AP3B2 AP3B1 AP3S1 AP3D1	axo-dendritic transport
GO:0099518	7.81144048072e-05	0.8	AP3B2 AP3B1 AP3S1 AP3D1	vesicle cytoskeletal trafficking
GO:0072384	0.000127362420754	0.8	AP3B2 AP3B1 AP3S1 AP3D1	organelle transport along microtubule
GO:0030117	0.00029151492518	0.8	AP3B2 AP3B1 AP3S1 AP3D1	membrane coat
GO:0048475	0.00029151492518	0.8	AP3B2 AP3B1 AP3S1 AP3D1	coated membrane
HP:0011125	0.000641107533884	0.4	AP3B1 AP3D1	Abnormality of dermal melanosomes
GO:1903232	0.000783132248318	0.6	AP3B1 AP3S1 AP3D1	melanosome assembly
GO:0060155	0.00127603542925	0.6	AP3B1 AP3S1 AP3D1	platelet dense granule organization
GO:0051640	0.0016666620207	1.0	AP3B2 AP3B1 AP3D1 AP3S1 RNF167	organelle localization
GO:0010970	0.00178074577644	0.8	AP3B2 AP3B1 AP3S1 AP3D1	transport along microtubule
GO:0099111	0.00286397125166	0.8	AP3B2 AP3B1 AP3S1 AP3D1	microtubule-based transport
GO:0051650	0.00417468244626	0.8	AP3B2 AP3B1 AP3S1 AP3D1	establishment of vesicle localization
GO:0030705	0.00469791606681	0.8	AP3B2 AP3B1 AP3S1 AP3D1	cytoskeleton-dependent intracellular transport
GO:0051648	0.00480818953079	0.8	AP3B2 AP3B1 AP3S1 AP3D1	vesicle localization
GO:0006901	0.00627040828674	0.6	AP3B2 AP3S1 AP3D1	vesicle coating
GO:0048753	0.00683974211741	0.6	AP3B1 AP3S1 AP3D1	pigment granule organization
GO:0032438	0.00683974211741	0.6	AP3B1 AP3S1 AP3D1	melanosome organization
HP:0001022	0.00768171284681	0.4	AP3B1 AP3D1	Albinism
GO:0033363	0.00807957978043	0.6	AP3B1 AP3S1 AP3D1	secretory granule organization
GO:0005768	0.0132545753315	1.0	AP3B2 AP3B1 AP3D1 AP3S1 RNF167	endosome
HP:0001107	0.0134337956242	0.4	AP3B1 AP3D1	Ocular albinism
GO:0048488	0.0135806930791	0.6	AP3B2 AP3S1 AP3D1	synaptic vesicle endocytosis
GO:0140238	0.0135806930791	0.6	AP3B2 AP3S1 AP3D1	presynaptic endocytosis
HP:0007513	0.0207761643339	0.4	AP3B1 AP3D1	Generalized hypopigmentation
REAC:R-HSA-432722	0.0215986811086	0.4	AP3B1 AP3S1	Golgi Associated Vesicle Biogenesis
GO:0036465	0.0237169649094	0.6	AP3B2 AP3S1 AP3D1	synaptic vesicle recycling
GO:0033059	0.0250826699056	0.6	AP3B1 AP3S1 AP3D1	cellular pigmentation
GO:0005769	0.0280745884658	0.8	AP3B2 AP3B1 AP3S1 AP3D1	early endosome
GO:0007018	0.0284935982879	0.8	AP3B2 AP3B1 AP3S1 AP3D1	microtubule-based movement
GO:0016050	0.0329457298686	0.8	AP3B2 AP3B1 AP3S1 AP3D1	vesicle organization
REAC:R-HSA-199992	0.0363707033179	0.4	AP3B1 AP3S1	trans-Golgi Network Vesicle Budding

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
AP3S1	AP3B2	1.0	0.054	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116
AP3B1	AP3S1	1.0	0.262	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction
AP3S1	AP3D1	0.999	0.482	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction
AP3S1	RNF167	0.999	0.044	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
AP3B1	AP3D1	0.993	0.806	bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM
AP3B1	AP3B2	0.991	0.04	bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
AP3D1	AP3B2	0.921	0.038	bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
AP3B1	RNF167	0.849	0.106	bioplex_WMM bioplex3_WMM WMM_only
AP3B2	RNF167	0.749	0.022	bioplex_WMM bioplex3_WMM WMM_only
AP3D1	RNF167	0.667	0.102	bioplex_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
AP3B1	huMAP3_03149.1 huMAP3_03536.1 huMAP3_04281.1 huMAP3_06230.1 huMAP3_11077.1 huMAP3_11493.1 huMAP3_12157.1 huMAP3_12325.1 huMAP3_12813.1 huMAP3_13727.1 huMAP3_13786.1 huMAP3_14281.1 huMAP3_15082.1
RNF167	huMAP3_03536.1 huMAP3_04969.1 huMAP3_05469.1 huMAP3_05839.1 huMAP3_06650.1 huMAP3_07176.1 huMAP3_08379.1 huMAP3_09767.1 huMAP3_12157.1 huMAP3_12660.1 huMAP3_13197.1 huMAP3_13699.1 huMAP3_14844.1 huMAP3_15082.1
AP3S1	huMAP3_03149.1 huMAP3_03536.1 huMAP3_04238.1 huMAP3_06230.1 huMAP3_12157.1 huMAP3_12325.1 huMAP3_12813.1 huMAP3_15082.1
AP3D1	huMAP3_03149.1 huMAP3_03536.1 huMAP3_04238.1 huMAP3_06230.1 huMAP3_11493.1 huMAP3_12157.1 huMAP3_12325.1 huMAP3_12813.1 huMAP3_13727.1 huMAP3_14281.1 huMAP3_15082.1
AP3B2	huMAP3_03149.1 huMAP3_03536.1 huMAP3_04238.1 huMAP3_06230.1 huMAP3_11493.1 huMAP3_12157.1 huMAP3_12325.1 huMAP3_12813.1 huMAP3_13727.1 huMAP3_14281.1 huMAP3_15082.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_03536.1