hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03542.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RPS6KA3 | Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) | 5 | UniProt NCBI |
| RPS6KA1 | Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-444257 | 3.58839967947e-05 | 1.0 | RPS6KA3 RPS6KA1 | RSK activation |
| REAC:R-HSA-199920 | 3.58839967947e-05 | 1.0 | RPS6KA3 RPS6KA1 | CREB phosphorylation |
| WP:WP4877 | 0.000185152102942 | 1.0 | RPS6KA3 RPS6KA1 | Host pathogen interaction of human coronaviruses MAPK signaling |
| REAC:R-HSA-881907 | 0.000205051410255 | 1.0 | RPS6KA3 RPS6KA1 | Gastrin-CREB signalling pathway via PKC and MAPK |
| KEGG:04720 | 0.000232637232791 | 1.0 | RPS6KA3 RPS6KA1 | Long-term potentiation |
| REAC:R-HSA-198753 | 0.000358839967947 | 1.0 | RPS6KA3 RPS6KA1 | ERK/MAPK targets |
| REAC:R-HSA-442742 | 0.000394723964742 | 1.0 | RPS6KA3 RPS6KA1 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling |
| KEGG:04914 | 0.000539893955346 | 1.0 | RPS6KA3 RPS6KA1 | Progesterone-mediated oocyte maturation |
| WP:WP304 | 0.000542687198278 | 1.0 | RPS6KA3 RPS6KA1 | Kit receptor signaling pathway |
| REAC:R-HSA-450282 | 0.000743311362176 | 1.0 | RPS6KA3 RPS6KA1 | MAPK targets/ Nuclear events mediated by MAP kinases |
| KEGG:04931 | 0.000772693757832 | 1.0 | RPS6KA3 RPS6KA1 | Insulin resistance |
| KEGG:04722 | 0.000804719987643 | 1.0 | RPS6KA3 RPS6KA1 | Neurotrophin signaling pathway |
| KEGG:04114 | 0.000870723283599 | 1.0 | RPS6KA3 RPS6KA1 | Oocyte meiosis |
| KEGG:05135 | 0.00106564434727 | 1.0 | RPS6KA3 RPS6KA1 | Yersinia infection |
| WP:WP5353 | 0.00114964558631 | 1.0 | RPS6KA3 RPS6KA1 | A network map of Macrophage stimulating protein MSP signaling |
| WP:WP477 | 0.0015923080853 | 1.0 | RPS6KA3 RPS6KA1 | Cytoplasmic ribosomal proteins |
| WP:WP4321 | 0.00174298358976 | 1.0 | RPS6KA3 RPS6KA1 | Thermogenesis |
| KEGG:04150 | 0.00176843313648 | 1.0 | RPS6KA3 RPS6KA1 | mTOR signaling pathway |
| REAC:R-HSA-437239 | 0.00176856841345 | 1.0 | RPS6KA3 RPS6KA1 | Recycling pathway of L1 |
| KEGG:05207 | 0.00214640767613 | 1.0 | RPS6KA3 RPS6KA1 | Chemical carcinogenesis - receptor activation |
| REAC:R-HSA-198725 | 0.0024452380673 | 1.0 | RPS6KA3 RPS6KA1 | Nuclear Events (kinase and transcription factor activation) |
| REAC:R-HSA-450294 | 0.00263149309828 | 1.0 | RPS6KA3 RPS6KA1 | MAP kinase activation |
| WP:WP3915 | 0.0027415280346 | 1.0 | RPS6KA3 RPS6KA1 | Angiopoietin like protein 8 regulatory pathway |
| WP:WP2380 | 0.00319355454799 | 1.0 | RPS6KA3 RPS6KA1 | Brain derived neurotrophic factor BDNF signaling pathway |
| REAC:R-HSA-448424 | 0.00323126847328 | 1.0 | RPS6KA3 RPS6KA1 | Interleukin-17 signaling |
| KEGG:04714 | 0.00339933231144 | 1.0 | RPS6KA3 RPS6KA1 | Thermogenesis |
| REAC:R-HSA-438064 | 0.00389255927135 | 1.0 | RPS6KA3 RPS6KA1 | Post NMDA receptor activation events |
| WP:WP481 | 0.00432149264637 | 1.0 | RPS6KA3 RPS6KA1 | Insulin signaling |
| WP:WP437 | 0.00438235873998 | 1.0 | RPS6KA3 RPS6KA1 | EGF EGFR signaling pathway |
| GO:0004711 | 0.00468200720083 | 1.0 | RPS6KA3 RPS6KA1 | ribosomal protein S6 kinase activity |
| KEGG:04010 | 0.0047800367266 | 1.0 | RPS6KA3 RPS6KA1 | MAPK signaling pathway |
| REAC:R-HSA-442755 | 0.00539968713673 | 1.0 | RPS6KA3 RPS6KA1 | Activation of NMDA receptors and postsynaptic events |
| REAC:R-HSA-975871 | 0.00567479777882 | 1.0 | RPS6KA3 RPS6KA1 | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-168176 | 0.00567479777882 | 1.0 | RPS6KA3 RPS6KA1 | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-168142 | 0.00567479777882 | 1.0 | RPS6KA3 RPS6KA1 | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-975138 | 0.00595674346792 | 1.0 | RPS6KA3 RPS6KA1 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| REAC:R-HSA-168181 | 0.0061002794551 | 1.0 | RPS6KA3 RPS6KA1 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REAC:R-HSA-975155 | 0.0061002794551 | 1.0 | RPS6KA3 RPS6KA1 | MyD88 dependent cascade initiated on endosome |
| REAC:R-HSA-168138 | 0.00669151102134 | 1.0 | RPS6KA3 RPS6KA1 | Toll Like Receptor 9 (TLR9) Cascade |
| REAC:R-HSA-168164 | 0.00699737937497 | 1.0 | RPS6KA3 RPS6KA1 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-937061 | 0.00731008277561 | 1.0 | RPS6KA3 RPS6KA1 | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-166166 | 0.00731008277561 | 1.0 | RPS6KA3 RPS6KA1 | MyD88-independent TLR4 cascade |
| REAC:R-HSA-166058 | 0.00762962122326 | 1.0 | RPS6KA3 RPS6KA1 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-168188 | 0.00762962122326 | 1.0 | RPS6KA3 RPS6KA1 | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-181438 | 0.00795599471791 | 1.0 | RPS6KA3 RPS6KA1 | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-187037 | 0.00795599471791 | 1.0 | RPS6KA3 RPS6KA1 | Signaling by NTRK1 (TRKA) |
| REAC:R-HSA-168179 | 0.00795599471791 | 1.0 | RPS6KA3 RPS6KA1 | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-2559582 | 0.00795599471791 | 1.0 | RPS6KA3 RPS6KA1 | Senescence-Associated Secretory Phenotype (SASP) |
| REAC:R-HSA-373760 | 0.00880183178522 | 1.0 | RPS6KA3 RPS6KA1 | L1CAM interactions |
| REAC:R-HSA-166520 | 0.0110061344455 | 1.0 | RPS6KA3 RPS6KA1 | Signaling by NTRKs |
| REAC:R-HSA-166016 | 0.0128208394262 | 1.0 | RPS6KA3 RPS6KA1 | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-416476 | 0.0145501063194 | 1.0 | RPS6KA3 RPS6KA1 | G alpha (q) signalling events |
| REAC:R-HSA-168898 | 0.0171064139006 | 1.0 | RPS6KA3 RPS6KA1 | Toll-like Receptor Cascades |
| REAC:R-HSA-112314 | 0.0211937720117 | 1.0 | RPS6KA3 RPS6KA1 | Neurotransmitter receptors and postsynaptic signal transmission |
| REAC:R-HSA-2559583 | 0.0260158976762 | 1.0 | RPS6KA3 RPS6KA1 | Cellular Senescence |
| WP:WP5087 | 0.0293715080819 | 1.0 | RPS6KA3 RPS6KA1 | Pleural mesothelioma |
| REAC:R-HSA-112315 | 0.0350347422039 | 1.0 | RPS6KA3 RPS6KA1 | Transmission across Chemical Synapses |
| GO:0043027 | 0.0491610756088 | 1.0 | RPS6KA3 RPS6KA1 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process |
| HP:0009746 | 0.0499436884913 | 0.5 | RPS6KA3 | Thick nasal septum |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RPS6KA3 | RPS6KA1 | 0.998 | 0.154 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes