hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03546.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GABRB2 | Gamma-aminobutyric acid receptor subunit beta-2 (GABA(A) receptor subunit beta-2) | 5 | UniProt NCBI |
| GABRB3 | Gamma-aminobutyric acid receptor subunit beta-3 (GABA(A) receptor subunit beta-3) | 5 | UniProt NCBI |
| GABRA6 | Gamma-aminobutyric acid receptor subunit alpha-6 (GABA(A) receptor subunit alpha-6) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:05033 | 1.05732045184e-07 | 1.0 | GABRB2 GABRB3 GABRA6 | Nicotine addiction |
| WP:WP4159 | 1.56892712209e-07 | 1.0 | GABRB2 GABRB3 GABRA6 | GABA receptor signaling |
| WP:WP4829 | 2.83244056527e-07 | 1.0 | GABRB2 GABRB3 GABRA6 | mBDNF and proBDNF regulation of GABA neurotransmission |
| KEGG:04727 | 2.50251661292e-06 | 1.0 | GABRB2 GABRB3 GABRA6 | GABAergic synapse |
| KEGG:05032 | 2.61801737967e-06 | 1.0 | GABRB2 GABRB3 GABRA6 | Morphine addiction |
| REAC:R-HSA-977443 | 4.97397882464e-06 | 1.0 | GABRB2 GABRB3 GABRA6 | GABA receptor activation |
| GO:0022851 | 5.38272230028e-06 | 1.0 | GABRB2 GABRB3 GABRA6 | GABA-gated chloride ion channel activity |
| GO:0004890 | 1.15344049292e-05 | 1.0 | GABRB2 GABRB3 GABRA6 | GABA-A receptor activity |
| GO:1902711 | 1.15344049292e-05 | 1.0 | GABRB2 GABRB3 GABRA6 | GABA-A receptor complex |
| KEGG:04723 | 1.43040725693e-05 | 1.0 | GABRB2 GABRB3 GABRA6 | Retrograde endocannabinoid signaling |
| GO:1902710 | 2.11464090368e-05 | 1.0 | GABRB2 GABRB3 GABRA6 | GABA receptor complex |
| GO:0099095 | 2.11464090368e-05 | 1.0 | GABRB2 GABRB3 GABRA6 | ligand-gated monoatomic anion channel activity |
| GO:0016917 | 2.74903317479e-05 | 1.0 | GABRB2 GABRB3 GABRA6 | GABA receptor activity |
| GO:0007214 | 3.49876949518e-05 | 1.0 | GABRB2 GABRB3 GABRA6 | gamma-aminobutyric acid signaling pathway |
| KEGG:04080 | 5.60236181806e-05 | 1.0 | GABRB2 GABRB3 GABRA6 | Neuroactive ligand-receptor interaction |
| GO:0051932 | 0.000170228592746 | 1.0 | GABRB2 GABRB3 GABRA6 | synaptic transmission, GABAergic |
| REAC:R-HSA-112314 | 0.000300937850546 | 1.0 | GABRB2 GABRB3 GABRA6 | Neurotransmitter receptors and postsynaptic signal transmission |
| GO:1902476 | 0.000629105668845 | 1.0 | GABRB2 GABRB3 GABRA6 | chloride transmembrane transport |
| REAC:R-HSA-112315 | 0.000640971827897 | 1.0 | GABRB2 GABRB3 GABRA6 | Transmission across Chemical Synapses |
| GO:0022835 | 0.000949666005835 | 1.0 | GABRB2 GABRB3 GABRA6 | transmitter-gated channel activity |
| GO:0022824 | 0.000949666005835 | 1.0 | GABRB2 GABRB3 GABRA6 | transmitter-gated monoatomic ion channel activity |
| GO:0005254 | 0.00136394338287 | 1.0 | GABRB2 GABRB3 GABRA6 | chloride channel activity |
| GO:0005230 | 0.00136394338287 | 1.0 | GABRB2 GABRB3 GABRA6 | extracellular ligand-gated monoatomic ion channel activity |
| GO:0098656 | 0.00136394338287 | 1.0 | GABRB2 GABRB3 GABRA6 | monoatomic anion transmembrane transport |
| GO:0098661 | 0.00145910222354 | 1.0 | GABRB2 GABRB3 GABRA6 | inorganic anion transmembrane transport |
| GO:0030594 | 0.00200169985542 | 1.0 | GABRB2 GABRB3 GABRA6 | neurotransmitter receptor activity |
| REAC:R-HSA-112316 | 0.00203732306248 | 1.0 | GABRB2 GABRB3 GABRA6 | Neuronal System |
| GO:0006821 | 0.00238416149886 | 1.0 | GABRB2 GABRB3 GABRA6 | chloride transport |
| KEGG:04726 | 0.00265115528622 | 0.666666666667 | GABRB2 GABRB3 | Serotonergic synapse |
| GO:0005253 | 0.00266444753864 | 1.0 | GABRB2 GABRB3 GABRA6 | monoatomic anion channel activity |
| GO:0015108 | 0.00439845307966 | 1.0 | GABRB2 GABRB3 GABRA6 | chloride transmembrane transporter activity |
| REAC:R-HSA-1236394 | 0.00614555007695 | 0.666666666667 | GABRB2 GABRB3 | Signaling by ERBB4 |
| GO:0006820 | 0.00623088554274 | 1.0 | GABRB2 GABRB3 GABRA6 | monoatomic anion transport |
| GO:0015698 | 0.00649050577369 | 1.0 | GABRB2 GABRB3 GABRA6 | inorganic anion transport |
| GO:0008509 | 0.00820096190464 | 1.0 | GABRB2 GABRB3 GABRA6 | monoatomic anion transmembrane transporter activity |
| GO:0015103 | 0.00949377645712 | 1.0 | GABRB2 GABRB3 GABRA6 | inorganic anion transmembrane transporter activity |
| GO:0071420 | 0.0140440992017 | 0.666666666667 | GABRB2 GABRB3 | cellular response to histamine |
| GO:0022834 | 0.0180186629002 | 1.0 | GABRB2 GABRB3 GABRA6 | ligand-gated channel activity |
| GO:0015276 | 0.0180186629002 | 1.0 | GABRB2 GABRB3 GABRA6 | ligand-gated monoatomic ion channel activity |
| GO:0034776 | 0.0294899169624 | 0.666666666667 | GABRB2 GABRB3 | response to histamine |
| HPA:0091062 | 0.0344398444789 | 0.666666666667 | GABRB2 GABRA6 | cerebellum; synaptic glomeruli - core[>=Medium] |
| WP:WP5420 | 0.0379798583444 | 0.666666666667 | GABRB2 GABRB3 | ADHD and autism ASD linked metabolic pathways and SNP |
| CORUM:5809 | 0.0499402709677 | 0.333333333333 | GABRB2 | GABA-A receptor (GABRA1, GABRB2, GABRG2) |
| CORUM:7461 | 0.0499402709677 | 0.333333333333 | GABRB2 | GABA-A receptor (GABRA1, GABRB2, GABRG2) |
| CORUM:7462 | 0.0499402709677 | 0.333333333333 | GABRB2 | GABA-A receptor (GABRA1, GABRB2, GABRD) |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GABRB2 | GABRB3 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| GABRB3 | GABRA6 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes