hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03561.1
Complex Portal: CPX-11493
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UNG | Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) | 5 | UniProt NCBI |
| CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) | 5 | UniProt NCBI |
| CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-111932 | 6.15154230766e-05 | 1.0 | CAMK2B CAMK2D | CaMK IV-mediated phosphorylation of CREB |
| WP:WP4875 | 0.000127691105477 | 1.0 | CAMK2B CAMK2D | Disruption of postsynaptic signaling by CNV |
| REAC:R-HSA-442982 | 0.000155497319444 | 1.0 | CAMK2B CAMK2D | Ras activation upon Ca2+ influx through NMDA receptor |
| KEGG:04971 | 0.000224021038984 | 1.0 | CAMK2B CAMK2D | Gastric acid secretion |
| REAC:R-HSA-438066 | 0.00023239159829 | 1.0 | CAMK2B CAMK2D | Unblocking of NMDA receptors, glutamate binding and activation |
| REAC:R-HSA-9617324 | 0.00023239159829 | 1.0 | CAMK2B CAMK2D | Negative regulation of NMDA receptor-mediated neuronal transmission |
| KEGG:04720 | 0.000232637232791 | 1.0 | CAMK2B CAMK2D | Long-term potentiation |
| WP:WP4756 | 0.000238782367243 | 1.0 | CAMK2B CAMK2D | Renin angiotensin aldosterone system RAAS |
| KEGG:05031 | 0.00025946123238 | 1.0 | CAMK2B CAMK2D | Amphetamine addiction |
| REAC:R-HSA-9620244 | 0.000261440548076 | 1.0 | CAMK2B CAMK2D | Long-term potentiation |
| WP:WP4008 | 0.00028347425416 | 1.0 | CAMK2B CAMK2D | NO cGMP PKG mediated neuroprotection |
| KEGG:04911 | 0.000338144964505 | 1.0 | CAMK2B CAMK2D | Insulin secretion |
| KEGG:05214 | 0.00037033376401 | 1.0 | CAMK2B CAMK2D | Glioma |
| KEGG:04912 | 0.00037033376401 | 1.0 | CAMK2B CAMK2D | GnRH signaling pathway |
| KEGG:04750 | 0.000381388503235 | 1.0 | CAMK2B CAMK2D | Inflammatory mediator regulation of TRP channels |
| REAC:R-HSA-442742 | 0.000394723964742 | 1.0 | CAMK2B CAMK2D | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling |
| KEGG:04713 | 0.000427233157076 | 1.0 | CAMK2B CAMK2D | Circadian entrainment |
| REAC:R-HSA-3371571 | 0.000432316723289 | 1.0 | CAMK2B CAMK2D | HSF1-dependent transactivation |
| KEGG:04925 | 0.000439100744773 | 1.0 | CAMK2B CAMK2D | Aldosterone synthesis and secretion |
| KEGG:04012 | 0.000463323629249 | 1.0 | CAMK2B CAMK2D | ErbB signaling pathway |
| REAC:R-HSA-5576892 | 0.000471618243588 | 1.0 | CAMK2B CAMK2D | Phase 0 - rapid depolarisation |
| REAC:R-HSA-399721 | 0.000512628525639 | 1.0 | CAMK2B CAMK2D | Glutamate binding, activation of AMPA receptors and synaptic plasticity |
| REAC:R-HSA-399719 | 0.000512628525639 | 1.0 | CAMK2B CAMK2D | Trafficking of AMPA receptors |
| KEGG:04740 | 0.000539893955346 | 1.0 | CAMK2B CAMK2D | Olfactory transduction |
| KEGG:04916 | 0.000553224670293 | 1.0 | CAMK2B CAMK2D | Melanogenesis |
| KEGG:04725 | 0.000636622923558 | 1.0 | CAMK2B CAMK2D | Cholinergic synapse |
| KEGG:04922 | 0.000680516741066 | 1.0 | CAMK2B CAMK2D | Glucagon signaling pathway |
| REAC:R-HSA-9022692 | 0.000693757271364 | 1.0 | CAMK2B CAMK2D | Regulation of MECP2 expression and activity |
| REAC:R-HSA-111997 | 0.000743311362176 | 1.0 | CAMK2B CAMK2D | CaM pathway |
| REAC:R-HSA-5673000 | 0.000743311362176 | 1.0 | CAMK2B CAMK2D | RAF activation |
| REAC:R-HSA-111933 | 0.000743311362176 | 1.0 | CAMK2B CAMK2D | Calmodulin induced events |
| KEGG:04066 | 0.00078862558789 | 1.0 | CAMK2B CAMK2D | HIF-1 signaling pathway |
| KEGG:04722 | 0.000804719987643 | 1.0 | CAMK2B CAMK2D | Neurotrophin signaling pathway |
| WP:WP4341 | 0.000831269096657 | 1.0 | CAMK2B CAMK2D | Non genomic actions of 1 25 dihydroxyvitamin D3 |
| REAC:R-HSA-111996 | 0.000847545829056 | 1.0 | CAMK2B CAMK2D | Ca-dependent events |
| KEGG:04114 | 0.000870723283599 | 1.0 | CAMK2B CAMK2D | Oocyte meiosis |
| KEGG:04728 | 0.00095688522167 | 1.0 | CAMK2B CAMK2D | Dopaminergic synapse |
| REAC:R-HSA-9656223 | 0.00101671324252 | 1.0 | CAMK2B CAMK2D | Signaling by RAF1 mutants |
| REAC:R-HSA-1489509 | 0.00107651990384 | 1.0 | CAMK2B CAMK2D | DAG and IP3 signaling |
| KEGG:04921 | 0.00112221860095 | 1.0 | CAMK2B CAMK2D | Oxytocin signaling pathway |
| KEGG:04261 | 0.0011414018249 | 1.0 | CAMK2B CAMK2D | Adrenergic signaling in cardiomyocytes |
| REAC:R-HSA-9649948 | 0.00120125951175 | 1.0 | CAMK2B CAMK2D | Signaling downstream of RAS mutants |
| REAC:R-HSA-6802955 | 0.00120125951175 | 1.0 | CAMK2B CAMK2D | Paradoxical activation of RAF signaling by kinase inactive BRAF |
| REAC:R-HSA-6802946 | 0.00120125951175 | 1.0 | CAMK2B CAMK2D | Signaling by moderate kinase activity BRAF mutants |
| REAC:R-HSA-936837 | 0.00120125951175 | 1.0 | CAMK2B CAMK2D | Ion transport by P-type ATPases |
| REAC:R-HSA-6802949 | 0.00120125951175 | 1.0 | CAMK2B CAMK2D | Signaling by RAS mutants |
| REAC:R-HSA-9609736 | 0.00120125951175 | 1.0 | CAMK2B CAMK2D | Assembly and cell surface presentation of NMDA receptors |
| KEGG:04148 | 0.00123975649005 | 1.0 | CAMK2B CAMK2D | Efferocytosis |
| KEGG:04934 | 0.00125991513217 | 1.0 | CAMK2B CAMK2D | Cushing syndrome |
| WP:WP673 | 0.00137906393915 | 1.0 | CAMK2B CAMK2D | ErbB signaling pathway |
| REAC:R-HSA-5578775 | 0.00140118463675 | 1.0 | CAMK2B CAMK2D | Ion homeostasis |
| REAC:R-HSA-112043 | 0.00147124386858 | 1.0 | CAMK2B CAMK2D | PLC beta mediated events |
| KEGG:04217 | 0.00151449927371 | 1.0 | CAMK2B CAMK2D | Necroptosis |
| KEGG:05152 | 0.001720800216 | 1.0 | CAMK2B CAMK2D | Tuberculosis |
| KEGG:04310 | 0.00181671633574 | 1.0 | CAMK2B CAMK2D | Wnt signaling pathway |
| REAC:R-HSA-112040 | 0.00184717145405 | 1.0 | CAMK2B CAMK2D | G-protein mediated events |
| KEGG:04360 | 0.00191523357059 | 1.0 | CAMK2B CAMK2D | Axon guidance |
| KEGG:04024 | 0.00201635192055 | 1.0 | CAMK2B CAMK2D | cAMP signaling pathway |
| WP:WP428 | 0.0021494669422 | 1.0 | CAMK2B CAMK2D | Wnt signaling |
| REAC:R-HSA-8986944 | 0.00235467369443 | 1.0 | CAMK2B CAMK2D | Transcriptional Regulation by MECP2 |
| KEGG:04020 | 0.00239074992693 | 1.0 | CAMK2B CAMK2D | Calcium signaling pathway |
| WP:WP5083 | 0.00259851399646 | 1.0 | CAMK2B CAMK2D | Neuroinflammation and glutamatergic signaling |
| KEGG:05417 | 0.00261899777797 | 1.0 | CAMK2B CAMK2D | Lipid and atherosclerosis |
| REAC:R-HSA-6802952 | 0.00263149309828 | 1.0 | CAMK2B CAMK2D | Signaling by BRAF and RAF1 fusions |
| WP:WP536 | 0.00264575970549 | 1.0 | CAMK2B CAMK2D | Calcium regulation in cardiac cells |
| KEGG:05205 | 0.00267768543767 | 1.0 | CAMK2B CAMK2D | Proteoglycans in cancer |
| KEGG:05415 | 0.00267768543767 | 1.0 | CAMK2B CAMK2D | Diabetic cardiomyopathy |
| GO:0005954 | 0.0028092043205 | 1.0 | CAMK2B CAMK2D | calcium- and calmodulin-dependent protein kinase complex |
| WP:WP289 | 0.00362429921046 | 1.0 | CAMK2B CAMK2D | Myometrial relaxation and contraction pathways |
| REAC:R-HSA-438064 | 0.00389255927135 | 1.0 | CAMK2B CAMK2D | Post NMDA receptor activation events |
| REAC:R-HSA-6802957 | 0.00424627295404 | 1.0 | CAMK2B CAMK2D | Oncogenic MAPK signaling |
| KEGG:05012 | 0.00458495309323 | 1.0 | CAMK2B CAMK2D | Parkinson disease |
| REAC:R-HSA-877300 | 0.00486997099357 | 1.0 | CAMK2B CAMK2D | Interferon gamma signaling |
| REAC:R-HSA-111885 | 0.00513141154164 | 1.0 | CAMK2B CAMK2D | Opioid Signalling |
| REAC:R-HSA-442755 | 0.00539968713673 | 1.0 | CAMK2B CAMK2D | Activation of NMDA receptors and postsynaptic events |
| REAC:R-HSA-5576891 | 0.0061002794551 | 1.0 | CAMK2B CAMK2D | Cardiac conduction |
| REAC:R-HSA-3371556 | 0.0061002794551 | 1.0 | CAMK2B CAMK2D | Cellular response to heat stress |
| REAC:R-HSA-983712 | 0.0130310171217 | 1.0 | CAMK2B CAMK2D | Ion channel transport |
| KEGG:05022 | 0.0138982457502 | 1.0 | CAMK2B CAMK2D | Pathways of neurodegeneration - multiple diseases |
| KEGG:05200 | 0.0161326036311 | 1.0 | CAMK2B CAMK2D | Pathways in cancer |
| REAC:R-HSA-397014 | 0.01909541258 | 1.0 | CAMK2B CAMK2D | Muscle contraction |
| REAC:R-HSA-112314 | 0.0211937720117 | 1.0 | CAMK2B CAMK2D | Neurotransmitter receptors and postsynaptic signal transmission |
| REAC:R-HSA-913531 | 0.0260158976762 | 1.0 | CAMK2B CAMK2D | Interferon Signaling |
| REAC:R-HSA-418594 | 0.0293992459454 | 1.0 | CAMK2B CAMK2D | G alpha (i) signalling events |
| REAC:R-HSA-112315 | 0.0350347422039 | 1.0 | CAMK2B CAMK2D | Transmission across Chemical Synapses |
| REAC:R-HSA-5673001 | 0.0385804228396 | 1.0 | CAMK2B CAMK2D | RAF/MAP kinase cascade |
| REAC:R-HSA-5684996 | 0.0400465404229 | 1.0 | CAMK2B CAMK2D | MAPK1/MAPK3 signaling |
| WP:WP1991 | 0.0435328773163 | 0.5 | CAMK2D | SRF and miRs in smooth muscle differentiation and proliferation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CAMK2B | CAMK2D | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM | ||
| UNG | CAMK2D | 0.973 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| UNG | CAMK2B | 0.284 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes