hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03577.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MFN2 | Mitofusin-2 (EC 3.6.5.-) (Transmembrane GTPase MFN2) | 5 | UniProt NCBI |
| TMC1 | Transmembrane channel-like protein 1 (Transmembrane cochlear-expressed protein 1) | 5 | UniProt NCBI |
| MFN1 | Mitofusin-1 (EC 3.6.5.-) (Fzo homolog) (Transmembrane GTPase MFN1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9013419 | 0.000143154936711 | 0.666666666667 | MFN1 MFN2 | RHOT2 GTPase cycle |
| REAC:R-HSA-9715370 | 0.000190864539041 | 0.666666666667 | MFN1 MFN2 | Miro GTPase Cycle |
| REAC:R-HSA-5205685 | 0.00143063482691 | 0.666666666667 | MFN1 MFN2 | PINK1-PRKN Mediated Mitophagy |
| REAC:R-HSA-5205647 | 0.00221357222266 | 0.666666666667 | MFN1 MFN2 | Mitophagy |
| KEGG:04137 | 0.00361241039138 | 0.666666666667 | MFN1 MFN2 | Mitophagy - animal |
| KEGG:04621 | 0.00802719593767 | 0.666666666667 | MFN1 MFN2 | NOD-like receptor signaling pathway |
| HP:0000360 | 0.0180650213362 | 0.666666666667 | MFN2 TMC1 | Tinnitus |
| REAC:R-HSA-9663891 | 0.0188582038017 | 0.666666666667 | MFN1 MFN2 | Selective autophagy |
| KEGG:05012 | 0.0212975456297 | 0.666666666667 | MFN1 MFN2 | Parkinson disease |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MFN1 | MFN2 | 0.994 | 0.286 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| TMC1 | MFN1 | 0.971 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TMC1 | MFN2 | 0.172 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes