hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03586.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| WIPF1 | WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein) | 5 | UniProt NCBI |
| WIPF2 | WAS/WASL-interacting protein family member 2 (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein) (WIP-related protein) | 5 | UniProt NCBI |
| WIPF3 | WAS/WASL-interacting protein family member 3 (Corticosteroids and regional expression protein 16 homolog) | 4 | UniProt NCBI |
| WASL | Actin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP) | 5 | UniProt NCBI |
| ARHGEF10L | Rho guanine nucleotide exchange factor 10-like protein (GrinchGEF) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5663213 | 1.97771129067e-08 | 0.8 | WIPF1 WIPF2 WASL WIPF3 | RHO GTPases Activate WASPs and WAVEs |
| REAC:R-HSA-9664422 | 1.24745525372e-07 | 0.8 | WIPF1 WIPF2 WASL WIPF3 | FCGR3A-mediated phagocytosis |
| REAC:R-HSA-9664417 | 1.24745525372e-07 | 0.8 | WIPF1 WIPF2 WASL WIPF3 | Leishmania phagocytosis |
| REAC:R-HSA-9664407 | 1.24745525372e-07 | 0.8 | WIPF1 WIPF2 WASL WIPF3 | Parasite infection |
| REAC:R-HSA-2029482 | 1.5644237257e-07 | 0.8 | WIPF1 WIPF2 WASL WIPF3 | Regulation of actin dynamics for phagocytic cup formation |
| REAC:R-HSA-2029480 | 6.0683312796e-07 | 0.8 | WIPF1 WIPF2 WASL WIPF3 | Fcgamma receptor (FCGR) dependent phagocytosis |
| KEGG:05135 | 8.77682510096e-07 | 0.8 | WIPF1 WIPF2 WASL WIPF3 | Yersinia infection |
| REAC:R-HSA-9012999 | 2.25495863817e-06 | 1.0 | WIPF1 ARHGEF10L WIPF2 WASL WIPF3 | RHO GTPase cycle |
| KEGG:05130 | 3.76938783575e-06 | 0.8 | WIPF1 WIPF2 WASL WIPF3 | Pathogenic Escherichia coli infection |
| REAC:R-HSA-9013148 | 4.24686934885e-06 | 0.8 | WIPF1 WIPF2 WASL WIPF3 | CDC42 GTPase cycle |
| REAC:R-HSA-9658195 | 5.78164213131e-06 | 0.8 | WIPF1 WIPF2 WASL WIPF3 | Leishmania infection |
| REAC:R-HSA-9824443 | 5.78164213131e-06 | 0.8 | WIPF1 WIPF2 WASL WIPF3 | Parasitic Infection Pathways |
| REAC:R-HSA-9013149 | 1.05854142603e-05 | 0.8 | WIPF1 WIPF2 WASL WIPF3 | RAC1 GTPase cycle |
| KEGG:04144 | 1.45802271707e-05 | 0.8 | WIPF1 WIPF2 WASL WIPF3 | Endocytosis |
| REAC:R-HSA-194315 | 2.37966097899e-05 | 1.0 | WIPF1 ARHGEF10L WIPF2 WASL WIPF3 | Signaling by Rho GTPases |
| REAC:R-HSA-9716542 | 2.65700424583e-05 | 1.0 | WIPF1 ARHGEF10L WIPF2 WASL WIPF3 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
| REAC:R-HSA-195258 | 0.000131735072349 | 0.8 | WIPF1 WIPF2 WASL WIPF3 | RHO GTPase Effectors |
| REAC:R-HSA-162582 | 0.00823431736973 | 1.0 | WIPF1 ARHGEF10L WIPF2 WASL WIPF3 | Signal Transduction |
| REAC:R-HSA-5663205 | 0.00938555933211 | 0.8 | WIPF1 WIPF2 WASL WIPF3 | Infectious disease |
| REAC:R-HSA-168249 | 0.0104601875414 | 0.8 | WIPF1 WIPF2 WASL WIPF3 | Innate Immune System |
| HPA:0381202 | 0.0117972006822 | 0.6 | WIPF1 WIPF2 WASL | placenta; hofbauer cells[>=Medium] |
| HPA:0380201 | 0.0132378743502 | 0.6 | WIPF1 WIPF2 WASL | placenta; endothelial cells[>=Low] |
| HPA:0381201 | 0.0168291444831 | 0.6 | WIPF1 WIPF2 WASL | placenta; hofbauer cells[>=Low] |
| REAC:R-HSA-9013409 | 0.0208015819243 | 0.4 | WIPF2 WASL | RHOJ GTPase cycle |
| CORUM:2513 | 0.0498708842806 | 0.2 | WASL | N-WASp homomer complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| WIPF2 | WASL | 0.999 | 0.244 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| WIPF1 | WASL | 0.997 | 0.13 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| WIPF3 | WASL | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| WIPF1 | WIPF2 | 0.993 | 0.16 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| ARHGEF10L | WASL | 0.989 | 0.1 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| WIPF1 | WIPF3 | 0.785 | bioplex_WMM bioplex3_WMM WMM_only | |
| WIPF2 | WIPF3 | 0.785 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes