hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_03635.1
Complex Portal: CPX-24480
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CBX2 | Chromobox protein homolog 2 | 5 | UniProt NCBI |
| PHC1 | Polyhomeotic-like protein 1 (hPH1) (Early development regulatory protein 1) | 5 | UniProt NCBI |
| SCMH1 | Polycomb protein SCMH1 (Sex comb on midleg homolog 1) | 5 | UniProt NCBI |
| SFMBT2 | Scm-like with four MBT domains protein 2 (Scm-like with 4 MBT domains protein 2) | 5 | UniProt NCBI |
| SCML1 | Sex comb on midleg-like protein 1 | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03083 | 2.23987247742e-10 | 1.0 | CBX2 SCML1 SFMBT2 PHC1 SCMH1 | Polycomb repressive complex |
| CORUM:115 | 4.62005379629e-07 | 0.6 | CBX2 PHC1 SCMH1 | Polycomb repressive complex 1 (PRC1, hPRC-H) |
| CORUM:116 | 4.62005379629e-07 | 0.6 | CBX2 PHC1 SCMH1 | Polycomb repressive complex 1 (PRC1, hPRC-H) |
| GO:0042393 | 2.71638125757e-05 | 1.0 | CBX2 SCML1 SFMBT2 PHC1 SCMH1 | histone binding |
| REAC:R-HSA-4655427 | 0.001593300657 | 0.4 | CBX2 PHC1 | SUMOylation of DNA methylation proteins |
| REAC:R-HSA-8939243 | 0.00953234360475 | 0.4 | CBX2 PHC1 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
| REAC:R-HSA-3899300 | 0.0106339701454 | 0.4 | CBX2 PHC1 | SUMOylation of transcription cofactors |
| REAC:R-HSA-4570464 | 0.0136499247655 | 0.4 | CBX2 PHC1 | SUMOylation of RNA binding proteins |
| REAC:R-HSA-8943724 | 0.0240791876622 | 0.4 | CBX2 PHC1 | Regulation of PTEN gene transcription |
| REAC:R-HSA-4551638 | 0.0323221445549 | 0.4 | CBX2 PHC1 | SUMOylation of chromatin organization proteins |
| GO:0045892 | 0.0359189932811 | 1.0 | CBX2 SCML1 SFMBT2 PHC1 SCMH1 | negative regulation of DNA-templated transcription |
| REAC:R-HSA-3108214 | 0.0374197925333 | 0.4 | CBX2 PHC1 | SUMOylation of DNA damage response and repair proteins |
| GO:1902679 | 0.0380488436301 | 1.0 | CBX2 SCML1 SFMBT2 PHC1 SCMH1 | negative regulation of RNA biosynthetic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PHC1 | SCMH1 | 1.0 | 0.156 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CBX2 | PHC1 | 0.999 | 0.13 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| PHC1 | SFMBT2 | 0.99 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| SCML1 | PHC1 | 0.984 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | ||
| CBX2 | SCMH1 | 0.861 | 0.152 | bioplex_WMM bioplex3_WMM WMM_only | |
| SCMH1 | SFMBT2 | 0.502 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CBX2 | SFMBT2 | 0.35 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SCML1 | SFMBT2 | 0.303 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SCML1 | SCMH1 | 0.202 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SCML1 | CBX2 | 0.198 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes