hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_03647.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NUP42 | Nucleoporin NUP42 (NLP-1) (NUP42 homolog) (Nucleoporin hCG1) (Nucleoporin-42) (Nucleoporin-like protein 2) | 5 | UniProt NCBI |
| NUP62 | Nuclear pore glycoprotein p62 (62 kDa nucleoporin) (Nucleoporin Nup62) | 5 | UniProt NCBI |
| GLE1 | mRNA export factor GLE1 (hGLE1) (GLE1 RNA export mediator) (GLE1-like protein) (Nucleoporin GLE1) | 5 | UniProt NCBI |
| RAE1 | mRNA export factor RAE1 (Rae1 protein homolog) (mRNA-associated protein mrnp 41) | 5 | UniProt NCBI |
| NUP98 | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | 5 | UniProt NCBI |
| NXT1 | NTF2-related export protein 1 (Protein p15) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03013 | 4.85144779109e-12 | 1.0 | NXT1 GLE1 NUP42 RAE1 NUP62 NUP98 | Nucleocytoplasmic transport |
| GO:0005643 | 1.39576248645e-09 | 1.0 | NXT1 GLE1 NUP42 RAE1 NUP62 NUP98 | nuclear pore |
| WP:WP3998 | 2.24052150595e-09 | 0.833333333333 | NUP42 GLE1 RAE1 NUP98 NUP62 | Prader Willi and Angelman syndrome |
| REAC:R-HSA-159236 | 2.39506375957e-09 | 0.833333333333 | NUP42 NXT1 GLE1 RAE1 NUP62 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| REAC:R-HSA-72202 | 4.45764769353e-09 | 0.833333333333 | NUP42 NXT1 GLE1 RAE1 NUP62 | Transport of Mature Transcript to Cytoplasm |
| GO:0051168 | 3.7833177994e-08 | 1.0 | NXT1 GLE1 NUP42 RAE1 NUP62 NUP98 | nuclear export |
| GO:0051169 | 9.69147168835e-07 | 1.0 | NXT1 GLE1 NUP42 RAE1 NUP62 NUP98 | nuclear transport |
| GO:0006913 | 9.69147168835e-07 | 1.0 | NXT1 GLE1 NUP42 RAE1 NUP62 NUP98 | nucleocytoplasmic transport |
| KEGG:05014 | 1.58391086806e-06 | 0.833333333333 | NUP62 NXT1 RAE1 NUP98 GLE1 | Amyotrophic lateral sclerosis |
| GO:0006405 | 1.7640596292e-06 | 0.833333333333 | NUP62 NXT1 RAE1 NUP98 GLE1 | RNA export from nucleus |
| REAC:R-HSA-72203 | 2.42636100074e-06 | 0.833333333333 | NUP42 NXT1 GLE1 RAE1 NUP62 | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0050657 | 5.71004820433e-06 | 0.833333333333 | NUP62 NXT1 RAE1 NUP98 GLE1 | nucleic acid transport |
| GO:0050658 | 5.71004820433e-06 | 0.833333333333 | NUP62 NXT1 RAE1 NUP98 GLE1 | RNA transport |
| GO:0051236 | 6.57276483676e-06 | 0.833333333333 | NUP62 NXT1 RAE1 NUP98 GLE1 | establishment of RNA localization |
| GO:0005635 | 9.20043332604e-06 | 1.0 | NXT1 GLE1 NUP42 RAE1 NUP62 NUP98 | nuclear envelope |
| GO:0006403 | 2.2353660091e-05 | 0.833333333333 | NUP62 NXT1 RAE1 NUP98 GLE1 | RNA localization |
| REAC:R-HSA-5619107 | 2.30646071149e-05 | 0.5 | NUP42 RAE1 NUP62 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) |
| REAC:R-HSA-170822 | 2.30646071149e-05 | 0.5 | NUP42 RAE1 NUP62 | Regulation of Glucokinase by Glucokinase Regulatory Protein |
| REAC:R-HSA-168333 | 2.57219421737e-05 | 0.5 | NUP42 RAE1 NUP62 | NEP/NS2 Interacts with the Cellular Export Machinery |
| REAC:R-HSA-168274 | 2.57219421737e-05 | 0.5 | NUP42 RAE1 NUP62 | Export of Viral Ribonucleoproteins from Nucleus |
| REAC:R-HSA-168271 | 2.57219421737e-05 | 0.5 | NUP42 RAE1 NUP62 | Transport of Ribonucleoproteins into the Host Nucleus |
| GO:0015931 | 3.06428171392e-05 | 0.833333333333 | NUP62 NXT1 RAE1 NUP98 GLE1 | nucleobase-containing compound transport |
| REAC:R-HSA-159227 | 3.16323162923e-05 | 0.5 | NUP42 RAE1 NUP62 | Transport of the SLBP independent Mature mRNA |
| REAC:R-HSA-180746 | 3.16323162923e-05 | 0.5 | NUP42 RAE1 NUP62 | Nuclear import of Rev protein |
| REAC:R-HSA-180910 | 3.16323162923e-05 | 0.5 | NUP42 RAE1 NUP62 | Vpr-mediated nuclear import of PICs |
| REAC:R-HSA-165054 | 3.48992434538e-05 | 0.5 | NUP42 RAE1 NUP62 | Rev-mediated nuclear export of HIV RNA |
| REAC:R-HSA-4085377 | 3.48992434538e-05 | 0.5 | NUP42 RAE1 NUP62 | SUMOylation of SUMOylation proteins |
| REAC:R-HSA-159230 | 3.48992434538e-05 | 0.5 | NUP42 RAE1 NUP62 | Transport of the SLBP Dependant Mature mRNA |
| REAC:R-HSA-3301854 | 3.83832488858e-05 | 0.5 | NUP42 RAE1 NUP62 | Nuclear Pore Complex (NPC) Disassembly |
| REAC:R-HSA-176033 | 4.20912658431e-05 | 0.5 | NUP42 RAE1 NUP62 | Interactions of Vpr with host cellular proteins |
| REAC:R-HSA-177243 | 4.20912658431e-05 | 0.5 | NUP42 RAE1 NUP62 | Interactions of Rev with host cellular proteins |
| REAC:R-HSA-3232142 | 4.60302232639e-05 | 0.5 | NUP42 RAE1 NUP62 | SUMOylation of ubiquitinylation proteins |
| CORUM:1348 | 5.12534978153e-05 | 0.333333333333 | NUP42 GLE1 | GLE1-NUPL2-NUP155 complex |
| REAC:R-HSA-168276 | 5.46286536752e-05 | 0.5 | NUP42 RAE1 NUP62 | NS1 Mediated Effects on Host Pathways |
| REAC:R-HSA-159231 | 5.93019629716e-05 | 0.5 | NUP42 RAE1 NUP62 | Transport of Mature mRNA Derived from an Intronless Transcript |
| REAC:R-HSA-159234 | 6.42338853456e-05 | 0.5 | NUP42 RAE1 NUP62 | Transport of Mature mRNAs Derived from Intronless Transcripts |
| REAC:R-HSA-168325 | 6.94313281717e-05 | 0.5 | NUP42 RAE1 NUP62 | Viral Messenger RNA Synthesis |
| REAC:R-HSA-4615885 | 8.06503831344e-05 | 0.5 | NUP42 RAE1 NUP62 | SUMOylation of DNA replication proteins |
| REAC:R-HSA-4570464 | 8.6685788479e-05 | 0.5 | NUP42 RAE1 NUP62 | SUMOylation of RNA binding proteins |
| REAC:R-HSA-2980766 | 0.000113827315454 | 0.5 | NUP42 RAE1 NUP62 | Nuclear Envelope Breakdown |
| REAC:R-HSA-194441 | 0.000146098747122 | 0.5 | NUP42 RAE1 NUP62 | Metabolism of non-coding RNA |
| REAC:R-HSA-191859 | 0.000146098747122 | 0.5 | NUP42 RAE1 NUP62 | snRNP Assembly |
| REAC:R-HSA-6784531 | 0.000183939263613 | 0.5 | NUP42 RAE1 NUP62 | tRNA processing in the nucleus |
| REAC:R-HSA-8953854 | 0.000234756919958 | 0.833333333333 | NUP42 NXT1 GLE1 RAE1 NUP62 | Metabolism of RNA |
| REAC:R-HSA-70171 | 0.000305777502474 | 0.5 | NUP42 RAE1 NUP62 | Glycolysis |
| REAC:R-HSA-3371453 | 0.000305777502474 | 0.5 | NUP42 RAE1 NUP62 | Regulation of HSF1-mediated heat shock response |
| REAC:R-HSA-4551638 | 0.000320288872929 | 0.5 | NUP42 RAE1 NUP62 | SUMOylation of chromatin organization proteins |
| REAC:R-HSA-1169408 | 0.000320288872929 | 0.5 | NUP42 RAE1 NUP62 | ISG15 antiviral mechanism |
| REAC:R-HSA-5619102 | 0.00038290615081 | 0.5 | NUP42 RAE1 NUP62 | SLC transporter disorders |
| REAC:R-HSA-3108214 | 0.000399737323057 | 0.5 | NUP42 RAE1 NUP62 | SUMOylation of DNA damage response and repair proteins |
| REAC:R-HSA-1169410 | 0.000417052782963 | 0.5 | NUP42 RAE1 NUP62 | Antiviral mechanism by IFN-stimulated genes |
| REAC:R-HSA-70326 | 0.000552388845795 | 0.5 | NUP42 RAE1 NUP62 | Glucose metabolism |
| REAC:R-HSA-3371556 | 0.000689296551176 | 0.5 | NUP42 RAE1 NUP62 | Cellular response to heat stress |
| REAC:R-HSA-5578749 | 0.00084703415394 | 0.5 | NUP42 RAE1 NUP62 | Transcriptional regulation by small RNAs |
| KEGG:05164 | 0.000948949329765 | 0.5 | NUP98 RAE1 NXT1 | Influenza A |
| REAC:R-HSA-72306 | 0.00109225187932 | 0.5 | NUP42 RAE1 NUP62 | tRNA processing |
| REAC:R-HSA-9610379 | 0.00109225187932 | 0.5 | NUP42 RAE1 NUP62 | HCMV Late Events |
| REAC:R-HSA-9705671 | 0.00158398146364 | 0.5 | NUP42 RAE1 NUP62 | SARS-CoV-2 activates/modulates innate and adaptive immune responses |
| REAC:R-HSA-211000 | 0.00185327127259 | 0.5 | NUP42 RAE1 NUP62 | Gene Silencing by RNA |
| REAC:R-HSA-9609690 | 0.00194934586886 | 0.5 | NUP42 RAE1 NUP62 | HCMV Early Events |
| REAC:R-HSA-68875 | 0.00204866370827 | 0.5 | NUP42 RAE1 NUP62 | Mitotic Prophase |
| REAC:R-HSA-162909 | 0.00220383625716 | 0.5 | NUP42 RAE1 NUP62 | Host Interactions of HIV factors |
| REAC:R-HSA-162599 | 0.00247941542207 | 0.5 | NUP42 RAE1 NUP62 | Late Phase of HIV Life Cycle |
| REAC:R-HSA-168273 | 0.00253713376791 | 0.5 | NUP42 RAE1 NUP62 | Influenza Viral RNA Transcription and Replication |
| GO:0031967 | 0.00310405054115 | 1.0 | NXT1 GLE1 NUP42 RAE1 NUP62 NUP98 | organelle envelope |
| GO:0031975 | 0.00310405054115 | 1.0 | NXT1 GLE1 NUP42 RAE1 NUP62 NUP98 | envelope |
| REAC:R-HSA-5619115 | 0.00316393974757 | 0.5 | NUP42 RAE1 NUP62 | Disorders of transmembrane transporters |
| REAC:R-HSA-9609646 | 0.00323172543915 | 0.5 | NUP42 RAE1 NUP62 | HCMV Infection |
| REAC:R-HSA-162587 | 0.00323172543915 | 0.5 | NUP42 RAE1 NUP62 | HIV Life Cycle |
| REAC:R-HSA-168255 | 0.00365870216205 | 0.5 | NUP42 RAE1 NUP62 | Influenza Infection |
| REAC:R-HSA-3108232 | 0.00445044283113 | 0.5 | NUP42 RAE1 NUP62 | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-2990846 | 0.00488555199885 | 0.5 | NUP42 RAE1 NUP62 | SUMOylation |
| REAC:R-HSA-913531 | 0.00604240808777 | 0.5 | NUP42 RAE1 NUP62 | Interferon Signaling |
| REAC:R-HSA-9705683 | 0.00748536008797 | 0.5 | NUP42 RAE1 NUP62 | SARS-CoV-2-host interactions |
| GO:0071705 | 0.00786016878989 | 1.0 | NXT1 GLE1 NUP42 RAE1 NUP62 NUP98 | nitrogen compound transport |
| GO:0046907 | 0.008082403103 | 1.0 | NXT1 GLE1 NUP42 RAE1 NUP62 NUP98 | intracellular transport |
| GO:0140513 | 0.0092737157774 | 1.0 | NXT1 GLE1 NUP42 RAE1 NUP62 NUP98 | nuclear protein-containing complex |
| REAC:R-HSA-162906 | 0.0121264165673 | 0.5 | NUP42 RAE1 NUP62 | HIV Infection |
| WP:WP5039 | 0.0132394005765 | 0.333333333333 | NUP98 RAE1 | SARS CoV 2 innate immunity evasion and cell specific immune response |
| REAC:R-HSA-71387 | 0.0187811350588 | 0.5 | NUP42 RAE1 NUP62 | Metabolism of carbohydrates |
| GO:0044614 | 0.0210651876021 | 0.333333333333 | GLE1 NUP98 | nuclear pore cytoplasmic filaments |
| REAC:R-HSA-9694516 | 0.0227330941007 | 0.5 | NUP42 RAE1 NUP62 | SARS-CoV-2 Infection |
| GO:0071702 | 0.0264962382684 | 1.0 | NXT1 GLE1 NUP42 RAE1 NUP62 NUP98 | organic substance transport |
| KEGG:03015 | 0.029291198851 | 0.333333333333 | GLE1 NXT1 | mRNA surveillance pathway |
| GO:0051649 | 0.0361725108126 | 1.0 | NXT1 GLE1 NUP42 RAE1 NUP62 NUP98 | establishment of localization in cell |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RAE1 | NUP62 | 1.0 | 0.528 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM |
| NUP42 | NXT1 | 0.998 | 0.16 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| NUP62 | NUP98 | 0.998 | 0.828 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM |
| NUP42 | GLE1 | 0.998 | 0.36 | hein_WMM youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| NXT1 | NUP62 | 0.998 | 0.25 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| RAE1 | GLE1 | 0.998 | 0.212 | hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| NUP42 | RAE1 | 0.994 | 0.522 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| NXT1 | RAE1 | 0.994 | 0.242 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| NXT1 | NUP98 | 0.993 | 0.486 | hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM hein () |
| NXT1 | GLE1 | 0.99 | 0.204 | hein_WMM youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| RAE1 | NUP98 | 0.987 | 0.514 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () gupta_WMM fraction boldt_WMM |
| NUP42 | NUP62 | 0.966 | 0.384 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| GLE1 | NUP98 | 0.944 | 0.384 | hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM hein () |
| NUP62 | GLE1 | 0.868 | 0.146 | hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| NUP42 | NUP98 | 0.393 | 0.492 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
Related Complexes