hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03690.1
Complex Portal: CPX-13129
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NCKAP1L | Nck-associated protein 1-like (Hematopoietic protein 1) (Membrane-associated protein HEM-1) | 5 | UniProt NCBI |
| PPFIA2 | Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2) | 5 | UniProt NCBI |
| BRK1 | Protein BRICK1 (BRK1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5663213 | 0.00381957013228 | 0.666666666667 | BRK1 NCKAP1L | RHO GTPases Activate WASPs and WAVEs |
| REAC:R-HSA-9664422 | 0.00937397262456 | 0.666666666667 | BRK1 NCKAP1L | FCGR3A-mediated phagocytosis |
| REAC:R-HSA-9664417 | 0.00937397262456 | 0.666666666667 | BRK1 NCKAP1L | Leishmania phagocytosis |
| REAC:R-HSA-9664407 | 0.00937397262456 | 0.666666666667 | BRK1 NCKAP1L | Parasite infection |
| KEGG:05130 | 0.0102516009655 | 0.666666666667 | BRK1 NCKAP1L | Pathogenic Escherichia coli infection |
| REAC:R-HSA-2029482 | 0.0104745554937 | 0.666666666667 | BRK1 NCKAP1L | Regulation of actin dynamics for phagocytic cup formation |
| KEGG:04810 | 0.01431202154 | 0.666666666667 | BRK1 NCKAP1L | Regulation of actin cytoskeleton |
| KEGG:05132 | 0.0188728482722 | 0.666666666667 | BRK1 NCKAP1L | Salmonella infection |
| REAC:R-HSA-2029480 | 0.0204048321881 | 0.666666666667 | BRK1 NCKAP1L | Fcgamma receptor (FCGR) dependent phagocytosis |
| REAC:R-HSA-9013404 | 0.0231174657298 | 0.666666666667 | BRK1 NCKAP1L | RAC2 GTPase cycle |
| REAC:R-HSA-9013423 | 0.0248259565326 | 0.666666666667 | BRK1 NCKAP1L | RAC3 GTPase cycle |
| REAC:R-HSA-4420097 | 0.0254089329805 | 0.666666666667 | BRK1 NCKAP1L | VEGFA-VEGFR2 Pathway |
| REAC:R-HSA-194138 | 0.0303152414298 | 0.666666666667 | BRK1 NCKAP1L | Signaling by VEGF |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| BRK1 | NCKAP1L | 0.997 | 0.322 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PPFIA2 | BRK1 | 0.97 | 0.124 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PPFIA2 | NCKAP1L | 0.415 | 0.066 | bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| NCKAP1L | huMAP3_02474.1 huMAP3_03690.1 huMAP3_09598.1 huMAP3_13345.1 huMAP3_13550.1 |
| PPFIA2 | huMAP3_01979.1 huMAP3_03690.1 huMAP3_09598.1 huMAP3_13345.1 huMAP3_13550.1 |
| BRK1 | huMAP3_01979.1 huMAP3_03690.1 huMAP3_09598.1 huMAP3_13345.1 huMAP3_13550.1 |