hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_03708.1
Complex Portal: CPX-10608
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MAP3K3 | Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) | 5 | UniProt NCBI |
| MAP3K2 | Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) | 5 | UniProt NCBI |
| MAP2K5 | Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3915 | 1.86398464173e-05 | 1.0 | MAP3K3 MAP3K2 MAP2K5 | Angiopoietin like protein 8 regulatory pathway |
| WP:WP481 | 3.69900149365e-05 | 1.0 | MAP3K3 MAP3K2 MAP2K5 | Insulin signaling |
| WP:WP437 | 3.77770365309e-05 | 1.0 | MAP3K3 MAP3K2 MAP2K5 | EGF EGFR signaling pathway |
| KEGG:04010 | 0.000123391020622 | 1.0 | MAP3K3 MAP3K2 MAP2K5 | MAPK signaling pathway |
| WP:WP422 | 0.000397139561296 | 0.666666666667 | MAP3K3 MAP3K2 | MAPK cascade |
| CORUM:5199 | 0.000409840887552 | 0.666666666667 | MAP3K3 MAP2K5 | Kinase maturation complex 1 |
| WP:WP5087 | 0.000659719901928 | 1.0 | MAP3K3 MAP3K2 MAP2K5 | Pleural mesothelioma |
| WP:WP195 | 0.00127505342928 | 0.666666666667 | MAP3K3 MAP3K2 | IL 1 signaling pathway |
| KEGG:04912 | 0.00173372250929 | 0.666666666667 | MAP3K3 MAP3K2 | GnRH signaling pathway |
| KEGG:04540 | 0.00189100482952 | 0.666666666667 | MAP2K5 MAP3K2 | Gap junction |
| KEGG:04722 | 0.00376179101737 | 0.666666666667 | MAP3K3 MAP2K5 | Neurotrophin signaling pathway |
| WP:WP2380 | 0.00845205977617 | 0.666666666667 | MAP2K5 MAP3K2 | Brain derived neurotrophic factor BDNF signaling pathway |
| WP:WP382 | 0.0225614433222 | 0.666666666667 | MAP2K5 MAP3K2 | MAPK signaling pathway |
| CORUM:7580 | 0.0499402709677 | 0.333333333333 | MAP3K3 | MAP2K4-MAP3K3-NBR1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MAP3K2 | MAP2K5 | 0.995 | 0.192 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| MAP3K3 | MAP2K5 | 0.994 | 0.082 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| MAP3K3 | MAP3K2 | 0.986 | 0.16 |
mutually_exclusive (Q13163)
|
hein_WMM bioplex_WMM bioplex3_WMM boldt hein () boldt_WMM |
Related Complexes