hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03710.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UBE2M | NEDD8-conjugating enzyme Ubc12 (EC 2.3.2.34) (NEDD8 carrier protein) (Ubiquitin-conjugating enzyme E2 M) | 5 | UniProt NCBI |
| NAE1 | NEDD8-activating enzyme E1 regulatory subunit (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1) (Amyloid protein-binding protein 1) (Proto-oncogene protein 1) | 5 | UniProt NCBI |
| UBA3 | NEDD8-activating enzyme E1 catalytic subunit (EC 6.2.1.64) (NEDD8-activating enzyme E1C) (Ubiquitin-activating enzyme E1C) (Ubiquitin-like modifier-activating enzyme 3) (Ubiquitin-activating enzyme 3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2162 | 3.41752350426e-06 | 0.666666666667 | NAE1 UBA3 | APPBP1-UBA3 complex |
| WP:WP4860 | 3.17081411632e-05 | 0.666666666667 | NAE1 UBA3 | Hijack of ubiquitination by SARS CoV 2 |
| GO:0045116 | 0.000281151120149 | 1.0 | UBE2M NAE1 UBA3 | protein neddylation |
| REAC:R-HSA-8951664 | 0.000874039130798 | 1.0 | UBE2M NAE1 UBA3 | Neddylation |
| GO:0019781 | 0.00140460216025 | 0.666666666667 | NAE1 UBA3 | NEDD8 activating enzyme activity |
| KEGG:04120 | 0.00686279305854 | 0.666666666667 | UBE2M UBA3 | Ubiquitin mediated proteolysis |
| REAC:R-HSA-5676590 | 0.0112421146161 | 0.666666666667 | UBE2M UBA3 | NIK-->noncanonical NF-kB signaling |
| REAC:R-HSA-5607761 | 0.0116360425406 | 0.666666666667 | UBE2M UBA3 | Dectin-1 mediated noncanonical NF-kB signaling |
| REAC:R-HSA-5668541 | 0.0248259565326 | 0.666666666667 | UBE2M UBA3 | TNFR2 non-canonical NF-kB pathway |
| REAC:R-HSA-5607764 | 0.0271982878007 | 0.666666666667 | UBE2M UBA3 | CLEC7A (Dectin-1) signaling |
| GO:0019788 | 0.0294899169624 | 0.666666666667 | UBE2M UBA3 | NEDD8 transferase activity |
| REAC:R-HSA-5621481 | 0.0484217025219 | 0.666666666667 | UBE2M UBA3 | C-type lectin receptors (CLRs) |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| UBE2M | UBA3 | 0.995 | 0.276 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| UBE2M | NAE1 | 0.993 | 0.202 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM |
| NAE1 | UBA3 | 0.982 | 0.98 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM fraction treiber_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| UBE2M | huMAP3_03710.1 huMAP3_05842.1 huMAP3_14442.1 |
| NAE1 | huMAP3_03710.1 huMAP3_06965.1 huMAP3_10866.1 huMAP3_11227.1 huMAP3_11249.1 |
| UBA3 | huMAP3_03710.1 huMAP3_05842.1 huMAP3_11227.1 |