hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03754.1
Complex Portal: CPX-12171
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HLA-DQA2 | HLA class II histocompatibility antigen, DQ alpha 2 chain (DX alpha chain) (HLA class II histocompatibility antigen, DQ(6) alpha chain) (HLA-DQA1) (MHC class II DQA2) | 5 | UniProt NCBI |
| DOP1B | Protein dopey-2 | 5 | UniProt NCBI |
| HLA-DPB1 | HLA class II histocompatibility antigen, DP beta 1 chain (HLA class II histocompatibility antigen, DP(W4) beta chain) (MHC class II antigen DPB1) | 5 | UniProt NCBI |
| TYW1B | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1B (EC 4.1.3.44) (Radical S-adenosyl methionine and flavodoxin domain-containing protein 2) (tRNA wybutosine-synthesizing protein 1 homolog B) | 4 | UniProt NCBI |
| HLA-DQA1 | HLA class II histocompatibility antigen, DQ alpha 1 chain (DC-1 alpha chain) (DC-alpha) (HLA-DCA) (MHC class II DQA1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-202430 | 8.91627220919e-07 | 0.6 | HLA-DQA2 HLA-DQA1 HLA-DPB1 | Translocation of ZAP-70 to Immunological synapse |
| REAC:R-HSA-202427 | 2.11908198931e-06 | 0.6 | HLA-DQA2 HLA-DQA1 HLA-DPB1 | Phosphorylation of CD3 and TCR zeta chains |
| REAC:R-HSA-389948 | 2.54263716986e-06 | 0.6 | HLA-DQA2 HLA-DQA1 HLA-DPB1 | PD-1 signaling |
| REAC:R-HSA-202433 | 6.30285051125e-06 | 0.6 | HLA-DQA2 HLA-DQA1 HLA-DPB1 | Generation of second messenger molecules |
| REAC:R-HSA-388841 | 9.08085842447e-05 | 0.6 | HLA-DQA2 HLA-DQA1 HLA-DPB1 | Costimulation by the CD28 family |
| GO:0002399 | 0.000115261178119 | 0.6 | HLA-DQA2 HLA-DQA1 HLA-DPB1 | MHC class II protein complex assembly |
| GO:0002503 | 0.000115261178119 | 0.6 | HLA-DQA2 HLA-DQA1 HLA-DPB1 | peptide antigen assembly with MHC class II protein complex |
| GO:0042613 | 0.000158467845213 | 0.6 | HLA-DQA2 HLA-DQA1 HLA-DPB1 | MHC class II protein complex |
| REAC:R-HSA-877300 | 0.000217750033404 | 0.6 | HLA-DQA2 HLA-DQA1 HLA-DPB1 | Interferon gamma signaling |
| GO:0002396 | 0.000274621184043 | 0.6 | HLA-DQA2 HLA-DQA1 HLA-DPB1 | MHC protein complex assembly |
| GO:0002501 | 0.000274621184043 | 0.6 | HLA-DQA2 HLA-DQA1 HLA-DPB1 | peptide antigen assembly with MHC protein complex |
| REAC:R-HSA-202424 | 0.000351286759397 | 0.6 | HLA-DQA2 HLA-DQA1 HLA-DPB1 | Downstream TCR signaling |
| GO:0042611 | 0.000537554131189 | 0.6 | HLA-DQA2 HLA-DQA1 HLA-DPB1 | MHC protein complex |
| REAC:R-HSA-202403 | 0.000595712868223 | 0.6 | HLA-DQA2 HLA-DQA1 HLA-DPB1 | TCR signaling |
| KEGG:05310 | 0.000616938529993 | 0.4 | HLA-DQA2 HLA-DPB1 | Asthma |
| REAC:R-HSA-2132295 | 0.000802337674321 | 0.6 | HLA-DQA2 HLA-DQA1 HLA-DPB1 | MHC class II antigen presentation |
| GO:0023026 | 0.00109385703544 | 0.6 | HLA-DQA2 HLA-DQA1 HLA-DPB1 | MHC class II protein complex binding |
| GO:0019886 | 0.00127603542925 | 0.6 | HLA-DQA2 HLA-DQA1 HLA-DPB1 | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| GO:0098553 | 0.00147736290187 | 0.6 | HLA-DQA2 HLA-DQA1 HLA-DPB1 | lumenal side of endoplasmic reticulum membrane |
| KEGG:05330 | 0.0015900664359 | 0.4 | HLA-DQA2 HLA-DPB1 | Allograft rejection |
| KEGG:04672 | 0.00171214467432 | 0.4 | HLA-DQA2 HLA-DPB1 | Intestinal immune network for IgA production |
| GO:0002495 | 0.00194127795747 | 0.6 | HLA-DQA2 HLA-DQA1 HLA-DPB1 | antigen processing and presentation of peptide antigen via MHC class II |
| KEGG:05332 | 0.00210534424221 | 0.4 | HLA-DQA2 HLA-DPB1 | Graft-versus-host disease |
| GO:0042605 | 0.00220577099344 | 0.6 | HLA-DQA2 HLA-DQA1 HLA-DPB1 | peptide antigen binding |
| GO:0002504 | 0.00220577099344 | 0.6 | HLA-DQA2 HLA-DQA1 HLA-DPB1 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
| REAC:R-HSA-913531 | 0.00269181495124 | 0.6 | HLA-DQA2 HLA-DQA1 HLA-DPB1 | Interferon Signaling |
| KEGG:04940 | 0.00269245905375 | 0.4 | HLA-DQA2 HLA-DPB1 | Type I diabetes mellitus |
| GO:0023023 | 0.00280458876292 | 0.6 | HLA-DQA2 HLA-DQA1 HLA-DPB1 | MHC protein complex binding |
| GO:0002478 | 0.00280458876292 | 0.6 | HLA-DQA2 HLA-DQA1 HLA-DPB1 | antigen processing and presentation of exogenous peptide antigen |
| KEGG:05320 | 0.00352719256651 | 0.4 | HLA-DQA2 HLA-DPB1 | Autoimmune thyroid disease |
| GO:0098576 | 0.00389166490199 | 0.6 | HLA-DQA2 HLA-DQA1 HLA-DPB1 | lumenal side of membrane |
| KEGG:05321 | 0.00408172507551 | 0.4 | HLA-DQA2 HLA-DPB1 | Inflammatory bowel disease |
| GO:0019884 | 0.00430818612204 | 0.6 | HLA-DQA2 HLA-DQA1 HLA-DPB1 | antigen processing and presentation of exogenous antigen |
| KEGG:05150 | 0.0057569162449 | 0.4 | HLA-DQA2 HLA-DPB1 | Staphylococcus aureus infection |
| KEGG:05416 | 0.00645863473927 | 0.4 | HLA-DQA2 HLA-DPB1 | Viral myocarditis |
| KEGG:04640 | 0.00771708586936 | 0.4 | HLA-DQA2 HLA-DPB1 | Hematopoietic cell lineage |
| KEGG:04612 | 0.00825154536734 | 0.4 | HLA-DQA2 HLA-DPB1 | Antigen processing and presentation |
| KEGG:05140 | 0.00852542753416 | 0.4 | HLA-DQA2 HLA-DPB1 | Leishmaniasis |
| KEGG:05323 | 0.0102617382696 | 0.4 | HLA-DQA2 HLA-DPB1 | Rheumatoid arthritis |
| GO:0005802 | 0.0116840674116 | 0.8 | HLA-DQA2 DOP1B HLA-DQA1 HLA-DPB1 | trans-Golgi network |
| KEGG:04658 | 0.012157220678 | 0.4 | HLA-DQA2 HLA-DPB1 | Th1 and Th2 cell differentiation |
| WP:WP2328 | 0.0128896073912 | 0.4 | HLA-DQA2 HLA-DPB1 | Allograft rejection |
| GO:0003823 | 0.0145266888919 | 0.6 | HLA-DQA2 HLA-DQA1 HLA-DPB1 | antigen binding |
| GO:0012507 | 0.016548216138 | 0.6 | HLA-DQA2 HLA-DQA1 HLA-DPB1 | ER to Golgi transport vesicle membrane |
| KEGG:04659 | 0.0179869923441 | 0.4 | HLA-DQA2 HLA-DPB1 | Th17 cell differentiation |
| KEGG:05145 | 0.0183886697314 | 0.4 | HLA-DQA2 HLA-DPB1 | Toxoplasmosis |
| GO:0048002 | 0.019918492568 | 0.6 | HLA-DQA2 HLA-DQA1 HLA-DPB1 | antigen processing and presentation of peptide antigen |
| GO:0098791 | 0.0223258532034 | 0.8 | HLA-DQA2 DOP1B HLA-DQA1 HLA-DPB1 | Golgi apparatus subcompartment |
| KEGG:04514 | 0.024008315736 | 0.4 | HLA-DQA2 HLA-DPB1 | Cell adhesion molecules |
| KEGG:05322 | 0.0258857078716 | 0.4 | HLA-DQA2 HLA-DPB1 | Systemic lupus erythematosus |
| GO:0030669 | 0.0327001087246 | 0.6 | HLA-DQA2 HLA-DQA1 HLA-DPB1 | clathrin-coated endocytic vesicle membrane |
| KEGG:04145 | 0.038606937256 | 0.4 | HLA-DQA2 HLA-DPB1 | Phagosome |
| WP:WP4217 | 0.0386238148414 | 0.4 | HLA-DQA2 HLA-DPB1 | Ebola virus infection in host |
| KEGG:05164 | 0.0458988724567 | 0.4 | HLA-DQA2 HLA-DPB1 | Influenza A |
| KEGG:05152 | 0.0471742362289 | 0.4 | HLA-DQA2 HLA-DPB1 | Tuberculosis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| HLA-DQA2 | HLA-DQA1 | 0.998 | 0.352 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| HLA-DPB1 | HLA-DQA1 | 0.994 | 0.342 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TYW1B | HLA-DQA1 | 0.985 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| DOP1B | HLA-DQA1 | 0.984 | 0.078 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TYW1B | HLA-DQA2 | 0.73 | bioplex3_WMM WMM_only | ||
| DOP1B | HLA-DQA2 | 0.703 | 0.054 | bioplex3_WMM WMM_only | |
| TYW1B | DOP1B | 0.153 | bioplex3_WMM WMM_only | ||
| HLA-DPB1 | TYW1B | 0.072 | bioplex_WMM bioplex3_WMM WMM_only | ||
| HLA-DPB1 | HLA-DQA2 | 0.045 | 0.406 | bioplex3_WMM WMM_only | |
| HLA-DPB1 | DOP1B | 0.013 | 0.106 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes