hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03755.1
Complex Portal: CPX-15943
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| IGF1R | Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] | 5 | UniProt NCBI |
| HPSE | Heparanase (EC 3.2.1.166) (Endo-glucoronidase) (Heparanase-1) (Hpa1) [Cleaved into: Heparanase 8 kDa subunit; Heparanase 50 kDa subunit] | 5 | UniProt NCBI |
| FIBIN | Fin bud initiation factor homolog | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:05205 | 0.0124702277162 | 0.666666666667 | IGF1R HPSE | Proteoglycans in cancer |
| WP:WP4186 | 0.0496447587094 | 0.333333333333 | IGF1R | Somatroph axis GH and its relationship to dietary restriction and aging |
| CORUM:6251 | 0.0499402709677 | 0.333333333333 | IGF1R | Shc-ERalpha-IGF-1R complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| IGF1R | FIBIN | 0.976 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| IGF1R | HPSE | 0.965 | 0.082 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| HPSE | FIBIN | 0.952 | bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| IGF1R | huMAP3_02023.1 huMAP3_03755.1 huMAP3_08471.1 huMAP3_08814.1 huMAP3_09152.1 huMAP3_09703.1 huMAP3_11006.1 |
| HPSE | huMAP3_03755.1 huMAP3_09152.1 |
| FIBIN | huMAP3_03755.1 huMAP3_09152.1 |