hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03756.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TPST1 | Protein-tyrosine sulfotransferase 1 (EC 2.8.2.20) (Tyrosylprotein sulfotransferase 1) (TPST-1) | 5 | UniProt NCBI |
| CITED2 | Cbp/p300-interacting transactivator 2 (MSG-related protein 1) (MRG-1) (P35srj) | 5 | UniProt NCBI |
| TPST2 | Protein-tyrosine sulfotransferase 2 (EC 2.8.2.20) (Tyrosylprotein sulfotransferase 2) (TPST-2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9674519 | 6.81845708859e-06 | 0.666666666667 | TPST1 TPST2 | Defective F8 sulfation at Y1699 |
| REAC:R-HSA-9662001 | 6.81752388431e-05 | 0.666666666667 | TPST1 TPST2 | Defective factor VIII causes hemophilia A |
| REAC:R-HSA-9651496 | 0.000531572756485 | 0.666666666667 | TPST1 TPST2 | Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) |
| REAC:R-HSA-9671793 | 0.000531572756485 | 0.666666666667 | TPST1 TPST2 | Diseases of hemostasis |
| REAC:R-HSA-156584 | 0.000926675585137 | 0.666666666667 | TPST1 TPST2 | Cytosolic sulfonation of small molecules |
| GO:0008476 | 0.00140460216025 | 0.666666666667 | TPST1 TPST2 | protein-tyrosine sulfotransferase activity |
| GO:0006478 | 0.00140460216025 | 0.666666666667 | TPST1 TPST2 | peptidyl-tyrosine sulfation |
| REAC:R-HSA-163841 | 0.00453384142373 | 0.666666666667 | TPST1 TPST2 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation |
| GO:0006477 | 0.0140440992017 | 0.666666666667 | TPST1 TPST2 | protein sulfation |
| REAC:R-HSA-156580 | 0.0214696523361 | 0.666666666667 | TPST1 TPST2 | Phase II - Conjugation of compounds |
| HPA:0380513 | 0.030835510288 | 1.0 | TPST2 TPST1 CITED2 | placenta; decidual cells[High] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TPST1 | TPST2 | 0.999 | 0.114 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| CITED2 | TPST2 | 0.991 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TPST1 | CITED2 | 0.73 | bioplex3_WMM WMM_only |
Related Complexes