hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03767.1
Complex Portal: CPX-18485
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CAPN1 | Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP) | 5 | UniProt NCBI |
| CAPNS1 | Calpain small subunit 1 (CSS1) (Calcium-activated neutral proteinase small subunit) (CANP small subunit) (Calcium-dependent protease small subunit) (CDPS) (Calcium-dependent protease small subunit 1) (Calpain regulatory subunit) | 5 | UniProt NCBI |
| CAPN2 | Calpain-2 catalytic subunit (EC 3.4.22.53) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain large polypeptide L2) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6710 | 1.70876175213e-06 | 1.0 | CAPN1 CAPNS1 | Calpain 1 |
| REAC:R-HSA-8862803 | 0.000358839967947 | 1.0 | CAPN1 CAPNS1 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
| REAC:R-HSA-8863678 | 0.000358839967947 | 1.0 | CAPN1 CAPNS1 | Neurodegenerative Diseases |
| REAC:R-HSA-9734009 | 0.000471618243588 | 1.0 | CAPN1 CAPNS1 | Defective Intrinsic Pathway for Apoptosis |
| WP:WP185 | 0.00148377064565 | 1.0 | CAPN1 CAPNS1 | Integrin mediated cell adhesion |
| GO:0110158 | 0.0028092043205 | 1.0 | CAPN1 CAPNS1 | calpain complex |
| REAC:R-HSA-6809371 | 0.00377807223396 | 1.0 | CAPN1 CAPNS1 | Formation of the cornified envelope |
| REAC:R-HSA-6805567 | 0.00400875507049 | 1.0 | CAPN1 CAPNS1 | Keratinization |
| KEGG:05131 | 0.00417007523294 | 1.0 | CAPN1 CAPNS1 | Shigellosis |
| REAC:R-HSA-9645723 | 0.00699737937497 | 1.0 | CAPN1 CAPNS1 | Diseases of programmed cell death |
| REAC:R-HSA-1474228 | 0.00932983916662 | 1.0 | CAPN1 CAPNS1 | Degradation of the extracellular matrix |
| GO:0008303 | 0.016855225923 | 1.0 | CAPN1 CAPNS1 | caspase complex |
| HPA:0291163 | 0.0257438179996 | 1.0 | CAPN1 CAPNS1 | liver; cholangiocytes[High] |
| GO:0004198 | 0.0257510396046 | 1.0 | CAPN1 CAPNS1 | calcium-dependent cysteine-type endopeptidase activity |
| REAC:R-HSA-1474244 | 0.0442193366216 | 1.0 | CAPN1 CAPNS1 | Extracellular matrix organization |
| CORUM:6706 | 0.0499419797295 | 0.5 | CAPN1 | CAPN1-HSP90AB1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CAPN1 | CAPNS1 | 1.0 | 0.604 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| CAPN2 | CAPNS1 | 0.987 | 0.336 |
mutually_exclusive (Q96L46)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| CAPN2 | CAPN1 | 0.963 | 0.16 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM |
Related Complexes