hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03783.1
Complex Portal: CPX-22809
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ATP8B2 | Phospholipid-transporting ATPase ID (EC 7.6.2.1) (ATPase class I type 8B member 2) (P4-ATPase flippase complex alpha subunit ATP8B2) | 5 | UniProt NCBI |
| ADCY6 | Adenylate cyclase type 6 (EC 4.6.1.1) (ATP pyrophosphate-lyase 6) (Adenylate cyclase type VI) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) | 5 | UniProt NCBI |
| YIPF3 | Protein YIPF3 (Killer lineage protein 1) (Natural killer cell-specific antigen KLIP1) (YIP1 family member 3) [Cleaved into: Protein YIPF3, 36 kDa form III] | 5 | UniProt NCBI |
| SLC43A1 | Large neutral amino acids transporter small subunit 3 (L-type amino acid transporter 3) (Prostate cancer overexpressed gene 1 protein) (Solute carrier family 43 member 1) | 5 | UniProt NCBI |
| EBP | 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EC 5.3.3.5) (Cholestenol Delta-isomerase) (Delta(8)-Delta(7) sterol isomerase) (D8-D7 sterol isomerase) (Emopamil-binding protein) | 5 | UniProt NCBI |
| SLC22A5 | Organic cation/carnitine transporter 2 (High-affinity sodium-dependent carnitine cotransporter) (Solute carrier family 22 member 5) | 5 | UniProt NCBI |
| PIGW | Phosphatidylinositol-glycan biosynthesis class W protein (PIG-W) (EC 2.3.-.-) | 5 | UniProt NCBI |
| SLC6A8 | Sodium- and chloride-dependent creatine transporter 1 (CT1) (Creatine transporter 1) (Solute carrier family 6 member 8) | 5 | UniProt NCBI |
| SLC43A2 | Large neutral amino acids transporter small subunit 4 (L-type amino acid transporter 4) (Solute carrier family 43 member 2) | 5 | UniProt NCBI |
| ENDOD1 | Endonuclease domain-containing 1 protein (EC 3.1.30.-) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-382551 | 0.00331038810687 | 0.5 | ATP8B2 SLC22A5 SLC43A2 ADCY6 SLC43A1 | Transport of small molecules |
| GO:0060357 | 0.0210690324038 | 0.2 | SLC43A1 SLC43A2 | regulation of leucine import |
| GO:0060358 | 0.0210690324038 | 0.2 | SLC43A1 SLC43A2 | negative regulation of leucine import |
| GO:1905532 | 0.0210690324038 | 0.2 | SLC43A1 SLC43A2 | regulation of leucine import across plasma membrane |
| GO:1905533 | 0.0210690324038 | 0.2 | SLC43A1 SLC43A2 | negative regulation of leucine import across plasma membrane |
| REAC:R-HSA-352230 | 0.0233407803855 | 0.2 | SLC43A1 SLC43A2 | Amino acid transport across the plasma membrane |
| REAC:R-HSA-425407 | 0.0352765903098 | 0.3 | SLC22A5 SLC43A1 SLC43A2 | SLC-mediated transmembrane transport |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ENDOD1 | YIPF3 | 0.999 | 0.026 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PIGW | YIPF3 | 0.99 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ATP8B2 | YIPF3 | 0.987 | 0.066 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| YIPF3 | SLC43A1 | 0.981 | 0.094 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| YIPF3 | SLC22A5 | 0.978 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| YIPF3 | SLC6A8 | 0.977 | 0.076 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | |
| YIPF3 | SLC43A2 | 0.965 | 0.042 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| YIPF3 | EBP | 0.958 | 0.06 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | |
| ADCY6 | YIPF3 | 0.957 | 0.104 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ENDOD1 | EBP | 0.951 | 0.054 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| ADCY6 | ATP8B2 | 0.798 | 0.098 | bioplex_WMM bioplex3_WMM WMM_only | |
| ENDOD1 | SLC6A8 | 0.791 | 0.072 | bioplex_WMM bioplex3_WMM WMM_only | |
| ATP8B2 | SLC43A1 | 0.502 | 0.122 | bioplex_WMM bioplex3_WMM WMM_only | |
| SLC43A1 | SLC43A2 | 0.502 | 0.114 | bioplex_WMM bioplex3_WMM WMM_only | |
| ADCY6 | PIGW | 0.501 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PIGW | ATP8B2 | 0.473 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ATP8B2 | EBP | 0.38 | 0.074 | bioplex_WMM bioplex3_WMM WMM_only | |
| SLC22A5 | SLC43A2 | 0.333 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SLC43A1 | SLC22A5 | 0.262 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PIGW | EBP | 0.246 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | ||
| ATP8B2 | SLC22A5 | 0.239 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PIGW | SLC43A1 | 0.237 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PIGW | SLC22A5 | 0.202 | bioplex_WMM bioplex3_WMM WMM_only | ||
| EBP | SLC22A5 | 0.198 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | ||
| ENDOD1 | SLC22A5 | 0.186 | bioplex_WMM bioplex3_WMM WMM_only | ||
| EBP | SLC43A2 | 0.18 | 0.056 | bioplex_WMM bioplex3_WMM WMM_only | |
| SLC6A8 | SLC43A2 | 0.172 | 0.052 | bioplex_WMM bioplex3_WMM WMM_only | |
| PIGW | SLC43A2 | 0.172 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ENDOD1 | SLC43A1 | 0.169 | 0.062 | bioplex_WMM bioplex3_WMM WMM_only | |
| SLC43A1 | SLC6A8 | 0.165 | 0.09 | bioplex_WMM bioplex3_WMM WMM_only | |
| ADCY6 | SLC43A1 | 0.164 | 0.098 | bioplex_WMM bioplex3_WMM WMM_only | |
| SLC43A1 | EBP | 0.154 | 0.062 | bioplex_WMM bioplex3_WMM WMM_only | |
| ADCY6 | SLC43A2 | 0.143 | 0.21 | bioplex_WMM bioplex3_WMM WMM_only | |
| ATP8B2 | SLC43A2 | 0.143 | 0.118 | bioplex_WMM bioplex3_WMM WMM_only | |
| ENDOD1 | SLC43A2 | 0.143 | 0.044 | bioplex_WMM bioplex3_WMM WMM_only | |
| ADCY6 | EBP | 0.114 | 0.112 | bioplex_WMM bioplex3_WMM WMM_only | |
| ATP8B2 | SLC6A8 | 0.101 | 0.074 | bioplex_WMM bioplex3_WMM WMM_only | |
| ADCY6 | SLC22A5 | 0.091 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SLC22A5 | SLC6A8 | 0.091 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | ||
| PIGW | ENDOD1 | 0.075 | bioplex_WMM bioplex3_WMM WMM_only | ||
| EBP | SLC6A8 | 0.072 | 0.09 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| ENDOD1 | ATP8B2 | 0.052 | 0.04 | bioplex_WMM bioplex3_WMM WMM_only | |
| ADCY6 | SLC6A8 | 0.05 | 0.128 | bioplex_WMM bioplex3_WMM WMM_only | |
| PIGW | SLC6A8 | 0.043 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | ||
| ADCY6 | ENDOD1 | 0.023 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes