hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_03810.1

Complex Portal: CPX-17363

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
CCT4	T-complex protein 1 subunit delta (TCP-1-delta) (CCT-delta) (Stimulator of TAR RNA-binding)	5	UniProt NCBI
TUBA1B	Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain]	5	UniProt NCBI
KLHDC8A	Kelch domain-containing protein 8A (Substitute for delta-EGFR expression 1) (S-delta-E1)	2	UniProt NCBI
CSTF1	Cleavage stimulation factor subunit 1 (CF-1 50 kDa subunit) (Cleavage stimulation factor 50 kDa subunit) (CSTF 50 kDa subunit) (CstF-50)	4	UniProt NCBI
PDCD5	Programmed cell death protein 5 (TF-1 cell apoptosis-related protein 19) (Protein TFAR19)	5	UniProt NCBI
KLHL33	Kelch-like protein 33	2	UniProt NCBI
CCT6A	T-complex protein 1 subunit zeta (TCP-1-zeta) (Acute morphine dependence-related protein 2) (CCT-zeta-1) (HTR3) (Tcp20)	5	UniProt NCBI
CCT2	T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta)	5	UniProt NCBI
TUBD1	Tubulin delta chain (Delta-tubulin)	5	UniProt NCBI
TCP1	T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha)	5	UniProt NCBI
DNAAF10	Dynein axonemal assembly factor 10 (WD repeat-containing protein 92) (WD repeat-containing protein Monad)	4	UniProt NCBI
CCT8	T-complex protein 1 subunit theta (TCP-1-theta) (CCT-theta) (Chaperonin containing T-complex polypeptide 1 subunit 8) (Renal carcinoma antigen NY-REN-15)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:126	4.8526101193e-13	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	CCT complex (chaperonin containing TCP1 complex)
REAC:R-HSA-389960	3.26679106091e-12	0.5	TCP1 CCT2 CCT4 CCT6A TUBA1B CCT8	Formation of tubulin folding intermediates by CCT/TriC
REAC:R-HSA-390450	9.74753896145e-12	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	Folding of actin by CCT/TriC
REAC:R-HSA-389958	1.66744451073e-11	0.5	TCP1 CCT2 CCT4 CCT6A TUBA1B CCT8	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
GO:0005832	1.79354716891e-09	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	chaperonin-containing T-complex
GO:1904851	1.79354716891e-09	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	positive regulation of establishment of protein localization to telomere
REAC:R-HSA-389957	3.10155279603e-09	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	Prefoldin mediated transfer of substrate to CCT/TriC
GO:1904871	3.28685663218e-09	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	positive regulation of protein localization to Cajal body
GO:1904869	3.28685663218e-09	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	regulation of protein localization to Cajal body
GO:0070203	3.28685663218e-09	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	regulation of establishment of protein localization to telomere
CORUM:6247	3.31875503169e-09	0.333333333333	CCT4 CCT8 TCP1 CCT2	BBS-chaperonin complex
GO:0070202	5.63236100073e-09	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	regulation of establishment of protein localization to chromosome
GO:1904867	5.63236100073e-09	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	protein localization to Cajal body
GO:1903405	5.63236100073e-09	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	protein localization to nuclear body
REAC:R-HSA-390466	7.89836558114e-09	0.5	TCP1 CCT2 CCT4 CCT6A TUBA1B CCT8	Chaperonin-mediated protein folding
GO:1904816	9.14893106478e-09	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	positive regulation of protein localization to chromosome, telomeric region
REAC:R-HSA-6814122	1.24321544543e-08	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
REAC:R-HSA-391251	1.28457867429e-08	0.5	TCP1 CCT2 CCT4 CCT6A TUBA1B CCT8	Protein folding
GO:1990173	1.42259861189e-08	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	protein localization to nucleoplasm
REAC:R-HSA-390471	1.44315680825e-08	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	Association of TriC/CCT with target proteins during biosynthesis
GO:1904874	2.13304555418e-08	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	positive regulation of telomerase RNA localization to Cajal body
GO:1904814	2.13304555418e-08	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	regulation of protein localization to chromosome, telomeric region
GO:0070200	3.10137235014e-08	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	establishment of protein localization to telomere
GO:1904872	6.07860159258e-08	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	regulation of telomerase RNA localization to Cajal body
GO:0090685	8.24623491931e-08	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	RNA localization to nucleus
GO:0090670	8.24623491931e-08	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	RNA localization to Cajal body
GO:0090672	8.24623491931e-08	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	telomerase RNA localization
GO:0090671	8.24623491931e-08	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	telomerase RNA localization to Cajal body
GO:0061077	1.86078692347e-07	0.5	TCP1 CCT2 CCT4 CCT6A PDCD5 CCT8	chaperone-mediated protein folding
WP:WP4949	2.11290204713e-07	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	16p11 2 proximal deletion syndrome
REAC:R-HSA-5620922	4.20513695266e-07	0.333333333333	CCT4 CCT8 TCP1 CCT2	BBSome-mediated cargo-targeting to cilium
GO:0070199	4.65189095178e-07	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	establishment of protein localization to chromosome
GO:0070198	1.00617686388e-06	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	protein localization to chromosome, telomeric region
GO:0032212	1.19919285529e-06	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	positive regulation of telomere maintenance via telomerase
GO:1904358	1.9615126067e-06	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	positive regulation of telomere maintenance via telomere lengthening
GO:0044183	3.06908842743e-06	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	protein folding chaperone
GO:0101031	4.62738438832e-06	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	protein folding chaperone complex
REAC:R-HSA-5620920	1.1340547608e-05	0.333333333333	CCT4 CCT8 TCP1 CCT2	Cargo trafficking to the periciliary membrane
GO:0032210	1.64470159466e-05	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	regulation of telomere maintenance via telomerase
GO:0005874	2.61926015817e-05	0.583333333333	TCP1 TUBD1 CCT4 TUBA1B CCT2 CCT8 CCT6A	microtubule
GO:2000573	3.49402977733e-05	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	positive regulation of DNA biosynthetic process
GO:1904356	3.81014307417e-05	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	regulation of telomere maintenance via telomere lengthening
GO:0006278	6.71865565892e-05	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	RNA-templated DNA biosynthetic process
GO:0007004	6.71865565892e-05	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	telomere maintenance via telomerase
GO:0032206	6.71865565892e-05	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	positive regulation of telomere maintenance
REAC:R-HSA-5617833	6.85923705755e-05	0.416666666667	TCP1 CCT4 CCT8 TUBA1B CCT2	Cilium Assembly
GO:1900182	8.40974231799e-05	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	positive regulation of protein localization to nucleus
GO:0006457	8.56427135034e-05	0.5	TCP1 CCT2 CCT4 CCT6A PDCD5 CCT8	protein folding
GO:0010833	0.00015603756477	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	telomere maintenance via telomere lengthening
GO:0050821	0.000193162285739	0.5	TCP1 CCT2 DNAAF10 CCT4 CCT6A CCT8	protein stabilization
GO:0090666	0.000211268761872	0.25	CCT4 TCP1 CCT2	scaRNA localization to Cajal body
GO:1904951	0.000332677365007	0.5	TCP1 CCT2 CCT4 CCT6A PDCD5 CCT8	positive regulation of establishment of protein localization
REAC:R-HSA-1852241	0.000439377558667	0.416666666667	TCP1 CCT4 CCT8 TUBA1B CCT2	Organelle biogenesis and maintenance
GO:2000278	0.000442981130501	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	regulation of DNA biosynthetic process
GO:0032204	0.000516879718045	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	regulation of telomere maintenance
GO:0051082	0.000516879718045	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	unfolded protein binding
GO:1900180	0.000516879718045	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	regulation of protein localization to nucleus
GO:0099513	0.000529813417556	0.583333333333	TCP1 TUBD1 CCT4 TUBA1B CCT2 CCT8 CCT6A	polymeric cytoskeletal fiber
GO:2001252	0.000661600004126	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	positive regulation of chromosome organization
GO:0034502	0.000799182945333	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	protein localization to chromosome
GO:0031647	0.00154856511611	0.5	TCP1 CCT2 DNAAF10 CCT4 CCT6A CCT8	regulation of protein stability
GO:0006403	0.00281703067384	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	RNA localization
GO:0071897	0.00313308982074	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	DNA biosynthetic process
GO:0000723	0.00313308982074	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	telomere maintenance
GO:0099512	0.00377229059867	0.583333333333	TCP1 TUBD1 CCT4 TUBA1B CCT2 CCT8 CCT6A	supramolecular fiber
GO:0099081	0.00410996034142	0.583333333333	TCP1 TUBD1 CCT4 TUBA1B CCT2 CCT8 CCT6A	supramolecular polymer
GO:1903829	0.00531310018164	0.5	TCP1 CCT2 CCT4 CCT6A PDCD5 CCT8	positive regulation of protein localization
GO:0070201	0.00601455162263	0.5	TCP1 CCT2 CCT4 CCT6A PDCD5 CCT8	regulation of establishment of protein localization
GO:0072594	0.0061207283043	0.5	TCP1 CCT2 CCT4 CCT6A PDCD5 CCT8	establishment of protein localization to organelle
GO:0032200	0.00812179610849	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	telomere organization
HPA:0130242	0.0134896860779	0.75	CSTF1 TUBD1 DNAAF10 CCT4 CCT6A CCT8 TCP1 PDCD5 TUBA1B	colon; peripheral nerve/ganglion[>=Medium]
GO:0051604	0.0140146935419	0.5	TCP1 CCT2 CCT4 CCT6A PDCD5 CCT8	protein maturation
GO:0010638	0.0144439603156	0.5	TCP1 CCT2 CCT4 CCT6A PDCD5 CCT8	positive regulation of organelle organization
GO:0034504	0.0280697456527	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	protein localization to nucleus
GO:0033044	0.034176581638	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	regulation of chromosome organization
HPA:0570813	0.0347082956399	0.5	CCT8 CCT2 CCT4 CCT6A PDCD5 CSTF1	testis; spermatogonia cells[High]
GO:0051054	0.0404476283983	0.416666666667	TCP1 CCT4 CCT8 CCT6A CCT2	positive regulation of DNA metabolic process
REAC:R-HSA-9013418	0.0420840222149	0.166666666667	CCT2 CCT6A	RHOBTB2 GTPase cycle

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
CCT6A	TCP1	1.0	0.976
CCT2	CCT8	1.0	0.992
CCT6A	CCT2	0.999	0.988
CCT2	TCP1	0.999	0.992
CCT4	CCT2	0.999	0.98
CCT4	CCT6A	0.999	0.992
TCP1	CCT8	0.999	0.992
CCT4	TCP1	0.999	0.996
CCT6A	CCT8	0.999	0.988
CCT4	CCT8	0.999	0.992
CSTF1	CCT2	0.996	0.284
CCT2	TUBD1	0.996
PDCD5	CCT2	0.996	0.894
TUBA1B	TCP1	0.994		structurally_consistent (dimer)
TUBA1B	CCT8	0.992
KLHL33	TCP1	0.991
TUBA1B	CCT6A	0.991		structurally_consistent (dimer)
PDCD5	CCT6A	0.99	0.752
CCT4	PDCD5	0.989	0.88
CCT4	KLHDC8A	0.989
TUBA1B	CCT4	0.989
CCT4	TUBD1	0.988
PDCD5	CCT8	0.987	0.8784
CCT6A	TUBD1	0.987
DNAAF10	CCT6A	0.985	0.546
TUBD1	CCT8	0.983
DNAAF10	CCT2	0.981	0.356
TUBA1B	CCT2	0.981		structurally_consistent (dimer)
KLHDC8A	TCP1	0.979
DNAAF10	CCT8	0.978	0.684
DNAAF10	TCP1	0.977	0.654
TUBD1	TCP1	0.975
PDCD5	TCP1	0.975	0.812	structurally_consistent (dimer)
KLHDC8A	CCT6A	0.974
CSTF1	CCT4	0.973	0.23
KLHL33	CCT4	0.972
KLHDC8A	CCT2	0.972
KLHDC8A	CCT8	0.971
CSTF1	DNAAF10	0.971	0.074
DNAAF10	CCT4	0.969	0.508
KLHL33	CCT2	0.967
CSTF1	CCT8	0.967	0.298
CSTF1	TCP1	0.959	0.17
CSTF1	CCT6A	0.938	0.162
KLHL33	CCT8	0.888
KLHL33	CCT6A	0.885
TUBA1B	PDCD5	0.827
KLHL33	PDCD5	0.778
KLHL33	TUBA1B	0.616
DNAAF10	PDCD5	0.594	0.066
CSTF1	PDCD5	0.521	0.112
DNAAF10	TUBD1	0.428
KLHDC8A	PDCD5	0.354
CSTF1	TUBD1	0.176
PDCD5	TUBD1	0.15
DNAAF10	KLHL33	0.112
TUBA1B	KLHDC8A	0.061
DNAAF10	TUBA1B	0.043
TUBA1B	TUBD1	0.012
CSTF1	TUBA1B	0.001

Related Complexes

Genename	Complexes
CCT4	huMAP3_03810.1 huMAP3_06559.1 huMAP3_07938.1 huMAP3_09191.1 huMAP3_10656.1 huMAP3_14584.1
TUBA1B	huMAP3_02724.1 huMAP3_03810.1 huMAP3_06559.1 huMAP3_07544.1 huMAP3_07864.1 huMAP3_07938.1 huMAP3_08094.1 huMAP3_08179.1 huMAP3_09191.1 huMAP3_09233.1 huMAP3_09603.1 huMAP3_09670.1 huMAP3_10475.1 huMAP3_10656.1 huMAP3_10665.1 huMAP3_11156.1 huMAP3_14584.1
KLHDC8A	huMAP3_03810.1 huMAP3_06559.1 huMAP3_07938.1 huMAP3_09191.1 huMAP3_10656.1 huMAP3_14584.1
CSTF1	huMAP3_00102.1 huMAP3_03810.1 huMAP3_06559.1 huMAP3_07938.1 huMAP3_09096.1 huMAP3_09191.1 huMAP3_10656.1 huMAP3_11757.1 huMAP3_14584.1
PDCD5	huMAP3_03810.1 huMAP3_03993.1 huMAP3_06559.1 huMAP3_07938.1 huMAP3_09191.1 huMAP3_10656.1 huMAP3_14584.1 huMAP3_14626.1
KLHL33	huMAP3_02198.1 huMAP3_03810.1 huMAP3_06559.1 huMAP3_07061.1 huMAP3_07938.1 huMAP3_09191.1 huMAP3_10238.1 huMAP3_10656.1 huMAP3_14584.1
CCT6A	huMAP3_03810.1 huMAP3_06559.1 huMAP3_07938.1 huMAP3_09191.1 huMAP3_10656.1 huMAP3_14584.1
CCT2	huMAP3_03810.1 huMAP3_06559.1 huMAP3_07938.1 huMAP3_09191.1 huMAP3_10656.1 huMAP3_14584.1
TUBD1	huMAP3_03810.1 huMAP3_06559.1 huMAP3_07063.1 huMAP3_07938.1 huMAP3_09191.1 huMAP3_10656.1 huMAP3_12425.1 huMAP3_14584.1
TCP1	huMAP3_03810.1 huMAP3_06559.1 huMAP3_07938.1 huMAP3_09191.1 huMAP3_10656.1 huMAP3_14584.1
DNAAF10	huMAP3_00807.1 huMAP3_03810.1 huMAP3_06426.1 huMAP3_06559.1 huMAP3_07938.1 huMAP3_08487.1 huMAP3_09057.1 huMAP3_09191.1 huMAP3_10656.1 huMAP3_11092.1 huMAP3_14318.1 huMAP3_14584.1
CCT8	huMAP3_03810.1 huMAP3_06559.1 huMAP3_07938.1 huMAP3_09191.1 huMAP3_10656.1 huMAP3_14584.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_03810.1

Complex Portal: CPX-17363