hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_03854.1

Confidence: Extremely High

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Genename	Protein Name	Uniprot Annotation Score	Links
GRN	Progranulin (PGRN) (Acrogranin) (Epithelin precursor) (Glycoprotein of 88 Kda) (GP88) (Glycoprotein 88) (Granulin precursor) (PC cell-derived growth factor) (PCDGF) (Proepithelin) (PEPI) [Cleaved into: Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Epithelin-2) (Granulin B); Granulin-4 (Epithelin-1) (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)]	5	UniProt NCBI
PSAP	Prosaposin (Proactivator polypeptide) [Cleaved into: Saposin-A (Protein A); Saposin-B-Val; Saposin-B (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sphingolipid activator protein 1) (SAP-1) (Sulfatide/GM1 activator); Saposin-C (A1 activator) (Co-beta-glucosidase) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin-D (Component C) (Protein C)]	5	UniProt NCBI
SYT4	Synaptotagmin-4 (Synaptotagmin IV) (SytIV)	5	UniProt NCBI

Showing 1 to 3 of 3 entries

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Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
HP:0011813	0.000569225481094	0.666666666667	PSAP GRN	Increased cerebral lipofuscin
HP:0002333	0.00348901893966	0.666666666667	PSAP GRN	Motor deterioration
HP:0030891	0.00549749049527	0.666666666667	PSAP GRN	Periventricular white matter hyperintensities
HP:0002529	0.00708857159683	0.666666666667	PSAP GRN	Neuronal loss in central nervous system
HP:0007305	0.0103578783075	0.666666666667	PSAP GRN	CNS demyelination
HP:0002371	0.0148492820647	0.666666666667	PSAP GRN	Loss of speech
HP:0000649	0.0194392651505	0.666666666667	PSAP GRN	Abnormality of visual evoked potentials
HP:0002344	0.0215948176879	0.666666666667	PSAP GRN	Progressive neurologic deterioration
HP:0030890	0.0295957156854	0.666666666667	PSAP GRN	Hyperintensity of cerebral white matter on MRI
HP:0002312	0.0304647837379	0.666666666667	PSAP GRN	Clumsiness

Showing 1 to 10 of 11 entries

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Protein 1	Protein 2	Score	ProteomeHD	Evidence
PSAP	GRN	0.999	0.084	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
SYT4	GRN	0.962		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
PSAP	SYT4	0.16		bioplex_WMM bioplex3_WMM WMM_only

Showing 1 to 3 of 3 entries

Related Complexes

Genename	Complexes
PSAP	huMAP3_03854.1 huMAP3_11748.1 huMAP3_14105.1
SYT4	huMAP3_03854.1 huMAP3_11748.1
GRN	huMAP3_03854.1 huMAP3_11748.1