hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03854.1
Complex Portal: CPX-14280
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PSAP | Prosaposin (Proactivator polypeptide) [Cleaved into: Saposin-A (Protein A); Saposin-B-Val; Saposin-B (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sphingolipid activator protein 1) (SAP-1) (Sulfatide/GM1 activator); Saposin-C (A1 activator) (Co-beta-glucosidase) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin-D (Component C) (Protein C)] | 5 | UniProt NCBI |
| SYT4 | Synaptotagmin-4 (Synaptotagmin IV) (SytIV) | 5 | UniProt NCBI |
| GRN | Progranulin (PGRN) (Acrogranin) (Epithelin precursor) (Glycoprotein of 88 Kda) (GP88) (Glycoprotein 88) (Granulin precursor) (PC cell-derived growth factor) (PCDGF) (Proepithelin) (PEPI) [Cleaved into: Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Epithelin-2) (Granulin B); Granulin-4 (Epithelin-1) (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0011813 | 0.000569225481094 | 0.666666666667 | GRN PSAP | Increased cerebral lipofuscin |
| HP:0002333 | 0.00348901893966 | 0.666666666667 | GRN PSAP | Motor deterioration |
| HP:0030891 | 0.00549749049527 | 0.666666666667 | GRN PSAP | Periventricular white matter hyperintensities |
| HP:0002529 | 0.00708857159683 | 0.666666666667 | GRN PSAP | Neuronal loss in central nervous system |
| HP:0007305 | 0.0103578783075 | 0.666666666667 | GRN PSAP | CNS demyelination |
| HP:0002371 | 0.0148492820647 | 0.666666666667 | GRN PSAP | Loss of speech |
| HP:0000649 | 0.0194392651505 | 0.666666666667 | GRN PSAP | Abnormality of visual evoked potentials |
| HP:0002344 | 0.0215948176879 | 0.666666666667 | GRN PSAP | Progressive neurologic deterioration |
| HP:0030890 | 0.0295957156854 | 0.666666666667 | GRN PSAP | Hyperintensity of cerebral white matter on MRI |
| HP:0002312 | 0.0304647837379 | 0.666666666667 | GRN PSAP | Clumsiness |
| CORUM:7099 | 0.0499402709677 | 0.333333333333 | PSAP | ASAH1-NR5A1-SAPD complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PSAP | GRN | 0.999 | 0.084 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SYT4 | GRN | 0.962 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| PSAP | SYT4 | 0.16 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| PSAP | huMAP3_03854.1 huMAP3_11748.1 huMAP3_14105.1 |
| SYT4 | huMAP3_03854.1 huMAP3_11748.1 |
| GRN | huMAP3_03854.1 huMAP3_11748.1 |