hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03864.1
Complex Portal: CPX-19314
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TREX2 | Three prime repair exonuclease 2 (EC 3.1.11.2) (3'-5' exonuclease TREX2) | 5 | UniProt NCBI |
| S100A7A | Protein S100-A7A (S100 calcium-binding protein A15) (S100 calcium-binding protein A7-like 1) (S100 calcium-binding protein A7A) | 5 | UniProt NCBI |
| STAT3 | Signal transducer and activator of transcription 3 (Acute-phase response factor) | 5 | UniProt NCBI |
| SERPINB5 | Serpin B5 (Maspin) (Peptidase inhibitor 5) (PI-5) | 5 | UniProt NCBI |
| HMOX1 | Heme oxygenase 1 (HO-1) (EC 1.14.14.18) [Cleaved into: Heme oxygenase 1 soluble form] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4495 | 0.000264396631677 | 0.4 | HMOX1 STAT3 | IL 10 anti inflammatory signaling pathway |
| KEGG:05206 | 0.000486709886236 | 0.6 | SERPINB5 STAT3 HMOX1 | MicroRNAs in cancer |
| HP:0025420 | 0.00768171284681 | 0.4 | HMOX1 STAT3 | Diffuse alveolar hemorrhage |
| WP:WP5158 | 0.00998567643899 | 0.4 | HMOX1 STAT3 | Urotensin II mediated signaling pathway |
| HP:0002726 | 0.0161800923797 | 0.4 | HMOX1 STAT3 | Recurrent Staphylococcus aureus infections |
| HP:0007499 | 0.0176485923371 | 0.4 | HMOX1 STAT3 | Recurrent staphylococcal infections |
| KEGG:04066 | 0.0217595858915 | 0.4 | HMOX1 STAT3 | HIF-1 signaling pathway |
| HP:0040223 | 0.0224351839587 | 0.4 | HMOX1 STAT3 | Pulmonary hemorrhage |
| REAC:R-HSA-9707564 | 0.0258071378099 | 0.4 | HMOX1 STAT3 | Cytoprotection by HMOX1 |
| HPA:0470182 | 0.037477729829 | 0.6 | SERPINB5 STAT3 HMOX1 | skin 2; cells in granular layer[>=Medium] |
| CORUM:1522 | 0.0498708842806 | 0.2 | STAT3 | STAT3 homodimer complex |
| CORUM:7316 | 0.0498708842806 | 0.2 | STAT3 | NFKB1-STAT3 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TREX2 | SERPINB5 | 0.989 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt_WMM treiber_WMM WMM_only | ||
| TREX2 | HMOX1 | 0.988 | bioplex_WMM bioplex3_WMM WMM_only | ||
| TREX2 | S100A7A | 0.974 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| TREX2 | STAT3 | 0.969 | bioplex_WMM bioplex3_WMM WMM_only | ||
| STAT3 | HMOX1 | 0.963 | bioplex_WMM bioplex3_WMM WMM_only treiber_WMM | ||
| SERPINB5 | HMOX1 | 0.934 | 0.186 | bioplex_WMM bioplex3_WMM WMM_only treiber_WMM | |
| S100A7A | STAT3 | 0.851 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SERPINB5 | STAT3 | 0.79 | bioplex_WMM bioplex3_WMM fraction treiber_WMM | ||
| SERPINB5 | S100A7A | 0.768 | bioplex_WMM bioplex3_WMM WMM_only | ||
| S100A7A | HMOX1 | 0.68 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes