hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03867.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SDS | L-serine dehydratase/L-threonine deaminase (SDH) (EC 4.3.1.17) (L-serine deaminase) (L-threonine dehydratase) (TDH) (EC 4.3.1.19) | 5 | UniProt NCBI |
| NTF4 | Neurotrophin-4 (NT-4) (Neurotrophin-5) (NT-5) (Neutrophic factor 4) | 5 | UniProt NCBI |
| TNFRSF10A | Tumor necrosis factor receptor superfamily member 10A (Death receptor 4) (TNF-related apoptosis-inducing ligand receptor 1) (TRAIL receptor 1) (TRAIL-R1) (CD antigen CD261) | 5 | UniProt NCBI |
| FADD | FAS-associated death domain protein (FAS-associating death domain-containing protein) (Growth-inhibiting gene 3 protein) (Mediator of receptor induced toxicity) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-75158 | 0.000143154936711 | 0.666666666667 | FADD TNFRSF10A | TRAIL signaling |
| REAC:R-HSA-3371378 | 0.000306718584473 | 0.666666666667 | FADD TNFRSF10A | Regulation by c-FLIP |
| REAC:R-HSA-5218900 | 0.000306718584473 | 0.666666666667 | FADD TNFRSF10A | CASP8 activity is inhibited |
| REAC:R-HSA-69416 | 0.000306718584473 | 0.666666666667 | FADD TNFRSF10A | Dimerization of procaspase-8 |
| REAC:R-HSA-140534 | 0.000531572756485 | 0.666666666667 | FADD TNFRSF10A | Caspase activation via Death Receptors in the presence of ligand |
| REAC:R-HSA-5357769 | 0.0011650518872 | 0.666666666667 | FADD TNFRSF10A | Caspase activation via extrinsic apoptotic signalling pathway |
| REAC:R-HSA-5675482 | 0.00296224002415 | 0.666666666667 | FADD TNFRSF10A | Regulation of necroptotic cell death |
| REAC:R-HSA-5213460 | 0.00296224002415 | 0.666666666667 | FADD TNFRSF10A | RIPK1-mediated regulated necrosis |
| WP:WP1772 | 0.00338983502479 | 0.666666666667 | FADD TNFRSF10A | Apoptosis modulation and signaling |
| KEGG:04210 | 0.00542112539104 | 0.666666666667 | FADD TNFRSF10A | Apoptosis |
| KEGG:04217 | 0.00706776241177 | 0.666666666667 | FADD TNFRSF10A | Necroptosis |
| KEGG:05164 | 0.00780874825616 | 0.666666666667 | FADD TNFRSF10A | Influenza A |
| REAC:R-HSA-5218859 | 0.00937397262456 | 0.666666666667 | FADD TNFRSF10A | Regulated Necrosis |
| KEGG:05130 | 0.0102516009655 | 0.666666666667 | FADD TNFRSF10A | Pathogenic Escherichia coli infection |
| KEGG:05132 | 0.0188728482722 | 0.666666666667 | FADD TNFRSF10A | Salmonella infection |
| KEGG:00290 | 0.0223072199518 | 0.333333333333 | SDS | Valine, leucine and isoleucine biosynthesis |
| CORUM:5861 | 0.0249718442456 | 0.333333333333 | FADD | FAS-FADD-CASP10 complex |
| GO:0036462 | 0.0393180950424 | 0.666666666667 | FADD TNFRSF10A | TRAIL-activated apoptotic signaling pathway |
| CORUM:5473 | 0.0499402709677 | 0.333333333333 | FADD | DISC complex (FAS, FADD, CASP8) |
| CORUM:5800 | 0.0499402709677 | 0.333333333333 | FADD | DISC complex (FAS, FADD, CASP8) |
| CORUM:5808 | 0.0499402709677 | 0.333333333333 | FADD | DISC complex (CD95, FADD, CASP8) |
| CORUM:5856 | 0.0499402709677 | 0.333333333333 | FADD | AK2-FADD-caspase-10 (AFAC10) complex |
| CORUM:5859 | 0.0499402709677 | 0.333333333333 | FADD | FAS-FADD-CASP8-CASP10 complex |
| CORUM:5860 | 0.0499402709677 | 0.333333333333 | FADD | DISC complex (FAS, FADD, CASP8) |
| CORUM:5991 | 0.0499402709677 | 0.333333333333 | FADD | LRRK2-FADD-CASP8 complex |
| CORUM:6175 | 0.0499402709677 | 0.333333333333 | FADD | Caspase-10-SUMO-FADD/Drp1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| FADD | NTF4 | 0.98 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| SDS | FADD | 0.98 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| FADD | TNFRSF10A | 0.966 | 0.122 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes