hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03876.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RGS7 | Regulator of G-protein signaling 7 (RGS7) | 5 | UniProt NCBI |
| GNB5 | Guanine nucleotide-binding protein subunit beta-5 (Gbeta5) (Transducin beta chain 5) | 5 | UniProt NCBI |
| RGS6 | Regulator of G-protein signaling 6 (RGS6) (S914) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-6814122 | 3.05391101381e-06 | 1.0 | RGS7 GNB5 RGS6 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
| WP:WP536 | 1.76674836791e-05 | 1.0 | RGS7 GNB5 RGS6 | Calcium regulation in cardiac cells |
| WP:WP289 | 2.83821551935e-05 | 1.0 | RGS7 GNB5 RGS6 | Myometrial relaxation and contraction pathways |
| REAC:R-HSA-390466 | 4.60862934812e-05 | 1.0 | RGS7 GNB5 RGS6 | Chaperonin-mediated protein folding |
| REAC:R-HSA-391251 | 5.85958968853e-05 | 1.0 | RGS7 GNB5 RGS6 | Protein folding |
| REAC:R-HSA-418594 | 0.000492377243425 | 1.0 | RGS7 GNB5 RGS6 | G alpha (i) signalling events |
| REAC:R-HSA-388396 | 0.00381272507886 | 1.0 | RGS7 GNB5 RGS6 | GPCR downstream signalling |
| REAC:R-HSA-372790 | 0.00563898766183 | 1.0 | RGS7 GNB5 RGS6 | Signaling by GPCR |
| GO:0043547 | 0.0231134095574 | 1.0 | RGS7 GNB5 RGS6 | positive regulation of GTPase activity |
| CORUM:7213 | 0.0249718442456 | 0.333333333333 | GNB5 | GNAS-L-GNB5-GNG13 complex |
| CORUM:7146 | 0.0499402709677 | 0.333333333333 | GNB5 | GNAS-L-GNB1-GNG1 complex |
| CORUM:1491 | 0.0499402709677 | 0.333333333333 | RGS6 | RGS6-DNMT1-DMAP1 complex |
| CORUM:7156 | 0.0499402709677 | 0.333333333333 | GNB5 | GNAS-L-GNB5-GNG3 complex |
| CORUM:7164 | 0.0499402709677 | 0.333333333333 | GNB5 | GNAS-L-GNB5-GNG4 complex |
| CORUM:7169 | 0.0499402709677 | 0.333333333333 | GNB5 | GNAS-L-GNB5-GNG5 complex |
| CORUM:7174 | 0.0499402709677 | 0.333333333333 | GNB5 | GNAS-L-GNB5-GNG7 complex |
| CORUM:7179 | 0.0499402709677 | 0.333333333333 | GNB5 | GNAS-L-GNB5-GNG8 complex |
| CORUM:7194 | 0.0499402709677 | 0.333333333333 | GNB5 | GNAS-L-GNB5-GNG10 complex |
| CORUM:7203 | 0.0499402709677 | 0.333333333333 | GNB5 | GNAS-L-GNB5-GNG11 complex |
| CORUM:7208 | 0.0499402709677 | 0.333333333333 | GNB5 | GNAS-L-GNB5-GNG12 complex |
| CORUM:7096 | 0.0499402709677 | 0.333333333333 | GNB5 | GNAI1-GNB5-GNG13 complex |
| CORUM:7151 | 0.0499402709677 | 0.333333333333 | GNB5 | GNAS-L-GNB4-GNG2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GNB5 | RGS6 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RGS7 | GNB5 | 0.971 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RGS7 | RGS6 | 0.214 | bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| RGS7 | huMAP3_03876.1 huMAP3_07207.1 huMAP3_11254.1 huMAP3_11522.1 |
| GNB5 | huMAP3_03876.1 huMAP3_07207.1 huMAP3_11254.1 huMAP3_11522.1 |
| RGS6 | huMAP3_03876.1 huMAP3_11254.1 huMAP3_11522.1 |