hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03896.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| VPS54 | Vacuolar protein sorting-associated protein 54 (Hepatocellular carcinoma protein 8) (Tumor antigen HOM-HCC-8) (Tumor antigen SLP-8p) | 5 | UniProt NCBI |
| VPS52 | Vacuolar protein sorting-associated protein 52 homolog (SAC2 suppressor of actin mutations 2-like protein) | 5 | UniProt NCBI |
| VPS51 | Vacuolar protein sorting-associated protein 51 homolog (Another new gene 2 protein) (Protein fat-free homolog) | 5 | UniProt NCBI |
| GINS2 | DNA replication complex GINS protein PSF2 (GINS complex subunit 2) | 5 | UniProt NCBI |
| EIPR1 | EARP and GARP complex-interacting protein 1 (Endosome-associated recycling protein-interacting protein) (Golgi-associated retrograde protein-interacting protein) (Tumor-suppressing STF cDNA 1 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein) | 5 | UniProt NCBI |
| VPS50 | Syndetin (Coiled-coil domain-containing protein 132) (EARP/GARPII complex subunit VPS50) | 5 | UniProt NCBI |
| VPS53 | Vacuolar protein sorting-associated protein 53 homolog | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0000938 | 1.89092208334e-13 | 0.714285714286 | VPS52 EIPR1 VPS53 VPS54 VPS51 | GARP complex |
| GO:1990745 | 1.89092208334e-13 | 0.714285714286 | VPS50 VPS52 VPS53 EIPR1 VPS51 | EARP complex |
| CORUM:6459 | 1.92263483365e-12 | 0.571428571429 | VPS52 VPS53 VPS50 VPS51 | EARP complex |
| CORUM:6463 | 1.92263483365e-12 | 0.571428571429 | VPS52 VPS53 VPS54 VPS51 | GARP complex |
| REAC:R-HSA-6811440 | 6.32195304736e-07 | 0.571428571429 | VPS52 VPS53 VPS54 VPS51 | Retrograde transport at the Trans-Golgi-Network |
| GO:0099023 | 1.11776248114e-06 | 0.714285714286 | VPS52 EIPR1 VPS53 VPS54 VPS51 | vesicle tethering complex |
| GO:0032456 | 3.23760764817e-06 | 0.714285714286 | VPS50 VPS52 VPS53 EIPR1 VPS51 | endocytic recycling |
| GO:0042147 | 5.78516855405e-06 | 0.714285714286 | VPS52 EIPR1 VPS53 VPS54 VPS51 | retrograde transport, endosome to Golgi |
| GO:0016197 | 7.03155441234e-06 | 0.857142857143 | VPS53 VPS51 EIPR1 VPS52 VPS50 VPS54 | endosomal transport |
| GO:0016482 | 3.40876499387e-05 | 0.714285714286 | VPS52 EIPR1 VPS53 VPS54 VPS51 | cytosolic transport |
| GO:0098876 | 5.13111356965e-05 | 0.714285714286 | VPS50 VPS52 VPS53 EIPR1 VPS51 | vesicle-mediated transport to the plasma membrane |
| GO:0055037 | 6.7047322154e-05 | 0.714285714286 | VPS50 VPS52 VPS53 EIPR1 VPS51 | recycling endosome |
| REAC:R-HSA-6811442 | 0.00019386485278 | 0.571428571429 | VPS52 VPS53 VPS54 VPS51 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| GO:0005802 | 0.000706434838609 | 0.714285714286 | VPS52 EIPR1 VPS53 VPS54 VPS51 | trans-Golgi network |
| GO:0098791 | 0.00158704183469 | 0.714285714286 | VPS52 EIPR1 VPS53 VPS54 VPS51 | Golgi apparatus subcompartment |
| GO:0032588 | 0.00242637201585 | 0.571428571429 | VPS52 VPS53 VPS54 VPS51 | trans-Golgi network membrane |
| GO:0007041 | 0.00449874442284 | 0.571428571429 | VPS52 VPS53 VPS54 VPS51 | lysosomal transport |
| GO:0007034 | 0.0108952763413 | 0.571428571429 | VPS52 VPS53 VPS54 VPS51 | vacuolar transport |
| REAC:R-HSA-199991 | 0.0144304646027 | 0.571428571429 | VPS52 VPS53 VPS54 VPS51 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.0178473234243 | 0.571428571429 | VPS52 VPS53 VPS54 VPS51 | Vesicle-mediated transport |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| VPS51 | EIPR1 | 1.0 | 0.132 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM |
| VPS51 | VPS53 | 1.0 | 0.638 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM Malo fraction boldt_WMM |
| EIPR1 | VPS50 | 0.999 | 0.154 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 boldt_WMM |
| VPS54 | VPS53 | 0.999 | 0.3 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| VPS52 | VPS50 | 0.999 | 0.36 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 |
| VPS51 | VPS50 | 0.999 | 0.538 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () Malo fraction boldt_WMM |
| VPS50 | VPS53 | 0.999 | 0.502 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 fraction boldt_WMM |
| VPS52 | EIPR1 | 0.999 | 0.092 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
| VPS54 | EIPR1 | 0.999 | 0.186 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| EIPR1 | VPS53 | 0.999 | 0.182 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM |
| VPS52 | VPS53 | 0.997 | 0.364 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| VPS54 | VPS50 | 0.997 | 0.14 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM |
| VPS54 | GINS2 | 0.993 | 0.096 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| VPS52 | VPS51 | 0.992 | 0.538 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only |
| GINS2 | VPS50 | 0.987 | 0.014 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| VPS54 | VPS52 | 0.975 | 0.386 | bioplex_WMM bioplex3_WMM WMM_only |
| VPS52 | GINS2 | 0.972 | 0.038 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| GINS2 | EIPR1 | 0.969 | 0.042 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| GINS2 | VPS53 | 0.942 | 0.04 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| VPS54 | VPS51 | 0.937 | 0.214 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| VPS51 | GINS2 | 0.927 | 0.026 | bioplex3_HEK293 bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
Related Complexes