hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_03898.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| FIG4 | Polyphosphoinositide phosphatase (EC 3.1.3.-) (EC 3.1.3.36) (EC 3.1.3.86) (Phosphatidylinositol 3,5-bisphosphate 5-phosphatase) (SAC domain-containing protein 3) (Serine-protein phosphatase FIG4) (EC 3.1.3.16) | 5 | UniProt NCBI |
| PIKFYVE | 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1) | 5 | UniProt NCBI |
| OSBPL1A | Oxysterol-binding protein-related protein 1 (ORP-1) (OSBP-related protein 1) | 5 | UniProt NCBI |
| VAC14 | Protein VAC14 homolog (Tax1-binding protein 2) | 5 | UniProt NCBI |
| MAVS | Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1660517 | 5.14505990951e-07 | 0.6 | FIG4 PIKFYVE VAC14 | Synthesis of PIPs at the late endosome membrane |
| REAC:R-HSA-1660516 | 1.41820648707e-06 | 0.6 | FIG4 PIKFYVE VAC14 | Synthesis of PIPs at the early endosome membrane |
| REAC:R-HSA-1660514 | 1.74530562074e-06 | 0.6 | FIG4 PIKFYVE VAC14 | Synthesis of PIPs at the Golgi membrane |
| CORUM:6186 | 4.09448956317e-05 | 0.4 | FIG4 PIKFYVE | ArPIKfyve-Sac3-Sph1 complex |
| HP:0000216 | 6.41370849429e-05 | 0.4 | FIG4 VAC14 | Broad secondary alveolar ridge |
| HP:0010111 | 6.41370849429e-05 | 0.4 | FIG4 VAC14 | Short phalanx of hallux |
| HP:0005793 | 6.41370849429e-05 | 0.4 | FIG4 VAC14 | Shortening of all distal phalanges of the toes |
| HP:0010102 | 6.41370849429e-05 | 0.4 | FIG4 VAC14 | Aplasia of the distal phalanx of the hallux |
| HP:0010110 | 6.41370849429e-05 | 0.4 | FIG4 VAC14 | Aplasia of the phalanges of the hallux |
| HP:0010085 | 6.41370849429e-05 | 0.4 | FIG4 VAC14 | Aplasia/Hypoplasia of the proximal phalanx of the hallux |
| HP:0010107 | 6.41370849429e-05 | 0.4 | FIG4 VAC14 | Short proximal phalanx of hallux |
| REAC:R-HSA-1483255 | 0.00018480745401 | 0.6 | FIG4 PIKFYVE VAC14 | PI Metabolism |
| HP:0012809 | 0.000192384920571 | 0.4 | FIG4 VAC14 | Narrow nasal base |
| HP:0010645 | 0.000192384920571 | 0.4 | FIG4 VAC14 | Aplasia of the distal phalanges of the toes |
| HP:0009881 | 0.000192384920571 | 0.4 | FIG4 VAC14 | Aplasia of the distal phalanges of the hand |
| HP:0010067 | 0.000384717178033 | 0.4 | FIG4 VAC14 | Aplasia/hypoplasia of the 1st metatarsal |
| HP:0001857 | 0.000384717178033 | 0.4 | FIG4 VAC14 | Short distal phalanx of toe |
| HP:0010076 | 0.000384717178033 | 0.4 | FIG4 VAC14 | Aplasia/Hypoplasia of the distal phalanx of the hallux |
| HP:0006628 | 0.000384717178033 | 0.4 | FIG4 VAC14 | Absent sternal ossification |
| HP:0005035 | 0.000384717178033 | 0.4 | FIG4 VAC14 | Shortening of all phalanges of the toes |
| HP:0010052 | 0.000641107533884 | 0.4 | FIG4 VAC14 | Abnormal morphology of the proximal phalanx of the hallux |
| HP:0010058 | 0.000641107533884 | 0.4 | FIG4 VAC14 | Aplasia/Hypoplasia of the phalanges of the hallux |
| HP:0010194 | 0.000641107533884 | 0.4 | FIG4 VAC14 | Aplasia/Hypoplasia of the middle phalanges of the toes |
| HP:0004993 | 0.000641107533884 | 0.4 | FIG4 VAC14 | Slender long bones with narrow diaphyses |
| HP:0030816 | 0.000961529670085 | 0.4 | FIG4 VAC14 | Gingival recession |
| HP:0010746 | 0.000961529670085 | 0.4 | FIG4 VAC14 | Hypoplasia of the phalanges of the toes |
| HP:0010035 | 0.000961529670085 | 0.4 | FIG4 VAC14 | Aplasia of the 1st metacarpal |
| HP:0010745 | 0.000961529670085 | 0.4 | FIG4 VAC14 | Aplasia of the phalanges of the toes |
| HP:0010242 | 0.001345957274 | 0.4 | FIG4 VAC14 | Aplasia of the proximal phalanges of the hand |
| HP:0009659 | 0.001345957274 | 0.4 | FIG4 VAC14 | Partial absence of thumb |
| HP:0010053 | 0.00230672366147 | 0.4 | FIG4 VAC14 | Abnormality of the distal phalanx of the hallux |
| HP:0010183 | 0.00230672366147 | 0.4 | FIG4 VAC14 | Abnormality of the middle phalanges of the toes |
| REAC:R-HSA-556833 | 0.00239005722097 | 0.8 | VAC14 FIG4 PIKFYVE OSBPL1A | Metabolism of lipids |
| REAC:R-HSA-1483257 | 0.0027382103682 | 0.6 | FIG4 PIKFYVE VAC14 | Phospholipid metabolism |
| HP:0010048 | 0.00288300984678 | 0.4 | FIG4 VAC14 | Aplasia of metacarpal bones |
| HP:0010185 | 0.00288300984678 | 0.4 | FIG4 VAC14 | Aplasia/Hypoplasia of the distal phalanges of the toes |
| HP:0001525 | 0.0035231963033 | 0.4 | FIG4 VAC14 | Severe failure to thrive |
| HP:0011863 | 0.0035231963033 | 0.4 | FIG4 VAC14 | Abnormal sternal ossification |
| HP:0009817 | 0.00422725674544 | 0.4 | FIG4 VAC14 | Aplasia involving bones of the lower limbs |
| HP:0009851 | 0.00422725674544 | 0.4 | FIG4 VAC14 | Aplasia/Hypoplasia of the proximal phalanges of the hand |
| HP:0000188 | 0.00422725674544 | 0.4 | FIG4 VAC14 | Short upper lip |
| HP:0010054 | 0.00422725674544 | 0.4 | FIG4 VAC14 | Abnormality of the first metatarsal bone |
| HP:0000187 | 0.00499516489297 | 0.4 | FIG4 VAC14 | Broad alveolar ridges |
| WP:WP5411 | 0.00503666229327 | 0.4 | FIG4 PIKFYVE | Phosphatidyl inositol phosphate pathway |
| HP:0009823 | 0.00582689447108 | 0.4 | FIG4 VAC14 | Aplasia involving bones of the upper limbs |
| HP:0009802 | 0.00582689447108 | 0.4 | FIG4 VAC14 | Aplasia of the phalanges of the hand |
| GO:0005770 | 0.00858929342321 | 0.8 | VAC14 FIG4 PIKFYVE OSBPL1A | late endosome |
| KEGG:00562 | 0.00937366158534 | 0.4 | FIG4 PIKFYVE | Inositol phosphate metabolism |
| HP:0001920 | 0.00979150178217 | 0.4 | FIG4 VAC14 | Renal artery stenosis |
| HP:0006714 | 0.00979150178217 | 0.4 | FIG4 VAC14 | Aplasia/Hypoplasia of the sternum |
| HP:0006323 | 0.00979150178217 | 0.4 | FIG4 VAC14 | Premature loss of primary teeth |
| HP:0040163 | 0.0109419445801 | 0.4 | FIG4 VAC14 | Abnormal pelvis bone morphology |
| HP:0010182 | 0.0109419445801 | 0.4 | FIG4 VAC14 | Abnormality of the distal phalanges of the toes |
| HP:0033836 | 0.0121560512731 | 0.4 | FIG4 VAC14 | Abnormal intrarenal artery morphology |
| HP:0008935 | 0.0121560512731 | 0.4 | FIG4 VAC14 | Generalized neonatal hypotonia |
| HP:0008776 | 0.0121560512731 | 0.4 | FIG4 VAC14 | Abnormal renal artery morphology |
| HP:0000162 | 0.0121560512731 | 0.4 | FIG4 VAC14 | Glossoptosis |
| HP:0009825 | 0.0134337956242 | 0.4 | FIG4 VAC14 | Aplasia involving bones of the extremities |
| HP:0033835 | 0.0134337956242 | 0.4 | FIG4 VAC14 | Abnormal renal vascular morphology |
| HP:0006713 | 0.0134337956242 | 0.4 | FIG4 VAC14 | Aplasia/Hypoplasia of the scapulae |
| HP:0009834 | 0.0147751514018 | 0.4 | FIG4 VAC14 | Abnormal proximal phalanx morphology of the hand |
| HP:0010173 | 0.0147751514018 | 0.4 | FIG4 VAC14 | Aplasia/Hypoplasia of the phalanges of the toes |
| HP:0007633 | 0.0161800923797 | 0.4 | FIG4 VAC14 | Bilateral microphthalmos |
| HP:0010537 | 0.0176485923371 | 0.4 | FIG4 VAC14 | Wide cranial sutures |
| HP:0010026 | 0.0191806250585 | 0.4 | FIG4 VAC14 | Aplasia/Hypoplasia of the 1st metacarpal |
| HP:0002696 | 0.0191806250585 | 0.4 | FIG4 VAC14 | Abnormal parietal bone morphology |
| HP:0012808 | 0.0207761643339 | 0.4 | FIG4 VAC14 | Abnormal nasal base norphology |
| HP:0005989 | 0.0224351839587 | 0.4 | FIG4 VAC14 | Redundant neck skin |
| HP:0010009 | 0.0224351839587 | 0.4 | FIG4 VAC14 | Abnormal 1st metacarpal morphology |
| HP:0100817 | 0.0224351839587 | 0.4 | FIG4 VAC14 | Renovascular hypertension |
| HP:0010109 | 0.0259435594648 | 0.4 | FIG4 VAC14 | Short hallux |
| HP:0009658 | 0.0316815705386 | 0.4 | FIG4 VAC14 | Aplasia/Hypoplasia of the phalanges of the thumb |
| HP:0008362 | 0.0316815705386 | 0.4 | FIG4 VAC14 | Aplasia/Hypoplasia of the hallux |
| HP:0000059 | 0.0337209222644 | 0.4 | FIG4 VAC14 | Hypoplastic labia majora |
| HP:0002139 | 0.0337209222644 | 0.4 | FIG4 VAC14 | Arrhinencephaly |
| HP:0002529 | 0.0358235710582 | 0.4 | FIG4 VAC14 | Neuronal loss in central nervous system |
| HP:0010057 | 0.0379894907585 | 0.4 | FIG4 VAC14 | Abnormal hallux phalanx morphology |
| HP:0006477 | 0.0379894907585 | 0.4 | FIG4 VAC14 | Abnormal alveolar ridge morphology |
| HP:0007333 | 0.0402186552091 | 0.4 | FIG4 VAC14 | Hypoplasia of the frontal lobes |
| HP:0004331 | 0.0425110382594 | 0.4 | FIG4 VAC14 | Decreased skull ossification |
| HP:0012881 | 0.0448666137641 | 0.4 | FIG4 VAC14 | Abnormal labia majora morphology |
| GO:0043813 | 0.0468008499735 | 0.4 | FIG4 PIKFYVE | phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity |
| HP:0001840 | 0.0497672375822 | 0.4 | FIG4 VAC14 | Metatarsus adductus |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PIKFYVE | VAC14 | 0.999 | 0.098 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| FIG4 | VAC14 | 0.999 | 0.334 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| FIG4 | PIKFYVE | 0.999 | 0.21 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| OSBPL1A | VAC14 | 0.98 | 0.056 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| MAVS | VAC14 | 0.954 | 0.066 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| OSBPL1A | FIG4 | 0.675 | 0.116 | bioplex3_WMM WMM_only |
| OSBPL1A | PIKFYVE | 0.675 | 0.094 | bioplex3_WMM WMM_only |
| MAVS | FIG4 | 0.105 | 0.05 | bioplex_WMM bioplex3_WMM WMM_only |
| MAVS | PIKFYVE | 0.044 | 0.054 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| OSBPL1A | MAVS | 0.01 | 0.04 | bioplex3_WMM WMM_only |
Related Complexes