hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03904.1
Complex Portal: CPX-21925
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PLAT | Tissue-type plasminogen activator (t-PA) (t-plasminogen activator) (tPA) (EC 3.4.21.68) (Alteplase) (Reteplase) [Cleaved into: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B] | 5 | UniProt NCBI |
| SERPINF2 | Alpha-2-antiplasmin (Alpha-2-AP) (Alpha-2-plasmin inhibitor) (Alpha-2-PI) (Serpin F2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP272 | 6.51224637934e-05 | 1.0 | PLAT SERPINF2 | Blood clotting cascade |
| REAC:R-HSA-75205 | 0.000133283416666 | 1.0 | PLAT SERPINF2 | Dissolution of Fibrin Clot |
| KEGG:04610 | 0.000403985690766 | 1.0 | PLAT SERPINF2 | Complement and coagulation cascades |
| WP:WP558 | 0.000460113616736 | 1.0 | PLAT SERPINF2 | Complement and coagulation cascades |
| GO:0010757 | 0.00702301080125 | 1.0 | PLAT SERPINF2 | negative regulation of plasminogen activation |
| GO:0051918 | 0.0210690324038 | 1.0 | PLAT SERPINF2 | negative regulation of fibrinolysis |
| GO:0051917 | 0.0426062655276 | 1.0 | PLAT SERPINF2 | regulation of fibrinolysis |
| HP:0040247 | 0.0499436884913 | 0.5 | SERPINF2 | Reduced euglobulin clot lysis time |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| SERPINF2 | PLAT | 0.962 | 0.31 |
mutually_exclusive (P05155)
|
bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| PLAT | huMAP3_03904.1 huMAP3_08889.1 |
| SERPINF2 | huMAP3_00178.1 huMAP3_03904.1 huMAP3_05943.1 huMAP3_07119.1 huMAP3_08889.1 huMAP3_11660.1 huMAP3_14445.1 huMAP3_14656.1 |