hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03912.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SDHC | Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (Integral membrane protein CII-3) (QPs-1) (QPs1) (Succinate dehydrogenase complex subunit C) (Succinate-ubiquinone oxidoreductase cytochrome B large subunit) (CYBL) | 5 | UniProt NCBI |
| DHODH | Dihydroorotate dehydrogenase (quinone), mitochondrial (DHOdehase) (EC 1.3.5.2) (Dihydroorotate oxidase) | 5 | UniProt NCBI |
| TMEM95 | Sperm-egg fusion protein TMEM95 (Transmembrane protein 95) | 4 | UniProt NCBI |
| SDHD | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial (CybS) (CII-4) (QPs3) (Succinate dehydrogenase complex subunit D) (Succinate-ubiquinone oxidoreductase cytochrome b small subunit) (Succinate-ubiquinone reductase membrane anchor subunit) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4920 | 7.14678770193e-05 | 0.5 | SDHC SDHD | Mitochondrial complex II assembly |
| HP:0030074 | 0.000200620835246 | 0.5 | SDHC SDHD | Chemodectoma |
| HP:0003001 | 0.000334337547576 | 0.5 | SDHC SDHD | Glomus jugular tumor |
| WP:WP78 | 0.000390164573598 | 0.5 | SDHC SDHD | TCA cycle aka Krebs or citric acid cycle |
| HP:0001686 | 0.000501460556964 | 0.5 | SDHC SDHD | Loss of voice |
| HP:0100780 | 0.000935888865729 | 0.5 | SDHC SDHD | Conjunctival hamartoma |
| KEGG:00020 | 0.00108828934266 | 0.5 | SDHC SDHD | Citrate cycle (TCA cycle) |
| HP:0003334 | 0.00120317586686 | 0.5 | SDHC SDHD | Elevated circulating catecholamine level |
| HP:0012099 | 0.00120317586686 | 0.5 | SDHC SDHD | Abnormality of circulating catecholamine level |
| REAC:R-HSA-71403 | 0.00214930898727 | 0.5 | SDHC SDHD | Citric acid cycle (TCA cycle) |
| HP:0005595 | 0.00220521848756 | 0.5 | SDHC SDHD | Generalized hyperkeratosis |
| HP:0004390 | 0.00260592941411 | 0.5 | SDHC SDHD | Hamartomatous polyposis |
| HP:0006731 | 0.00303997345979 | 0.5 | SDHC SDHD | Follicular thyroid carcinoma |
| HP:0008675 | 0.00303997345979 | 0.5 | SDHC SDHD | Enlarged polycystic ovaries |
| HP:0012222 | 0.00350734148159 | 0.5 | SDHC SDHD | Arachnoid hemangiomatosis |
| HP:0008629 | 0.00350734148159 | 0.5 | SDHC SDHD | Pulsatile tinnitus |
| HP:0003639 | 0.00350734148159 | 0.5 | SDHC SDHD | Elevated urinary epinephrine level |
| HP:0003574 | 0.00350734148159 | 0.5 | SDHC SDHD | Positive regitine blocking test |
| HP:0003345 | 0.00350734148159 | 0.5 | SDHC SDHD | Elevated urinary norepinephrine level |
| HP:0009711 | 0.00350734148159 | 0.5 | SDHC SDHD | Retinal capillary hemangioma |
| HP:0002864 | 0.00350734148159 | 0.5 | SDHC SDHD | Paraganglioma of head and neck |
| HP:0002640 | 0.00350734148159 | 0.5 | SDHC SDHD | Hypertension associated with pheochromocytoma |
| HP:0011979 | 0.00350734148159 | 0.5 | SDHC SDHD | Elevated urinary dopamine level |
| HP:0006737 | 0.00350734148159 | 0.5 | SDHC SDHD | Extraadrenal pheochromocytoma |
| HP:0000740 | 0.00350734148159 | 0.5 | SDHC SDHD | Episodic paroxysmal anxiety |
| HP:0006748 | 0.00400802433742 | 0.5 | SDHC SDHD | Adrenal pheochromocytoma |
| HP:0010532 | 0.00400802433742 | 0.5 | SDHC SDHD | Paroxysmal vertigo |
| HP:0100879 | 0.00400802433742 | 0.5 | SDHC SDHD | Enlarged ovaries |
| HP:0100642 | 0.00400802433742 | 0.5 | SDHC SDHD | Neoplasm of the adrenal medulla |
| HP:0100723 | 0.00454201288615 | 0.5 | SDHC SDHD | Gastrointestinal stroma tumor |
| HP:0100833 | 0.00454201288615 | 0.5 | SDHC SDHD | Neoplasm of the small intestine |
| HP:0010797 | 0.00454201288615 | 0.5 | SDHC SDHD | Hemangioblastoma |
| HP:0001095 | 0.00454201288615 | 0.5 | SDHC SDHD | Hypertensive retinopathy |
| HP:0002668 | 0.0051092979876 | 0.5 | SDHC SDHD | Paraganglioma |
| HP:0003528 | 0.00634372129255 | 0.5 | SDHC SDHD | Elevated circulating calcitonin concentration |
| HP:0011281 | 0.00634372129255 | 0.5 | SDHC SDHD | Abnormality of urine catecholamine level |
| HP:0011976 | 0.00634372129255 | 0.5 | SDHC SDHD | Elevated urinary catecholamine level |
| HP:0034902 | 0.00634372129255 | 0.5 | SDHC SDHD | Abnormal circulating calcitonin concentration |
| HP:0009594 | 0.00701084122037 | 0.5 | SDHC SDHD | Retinal hamartoma |
| HP:0200063 | 0.00771122114953 | 0.5 | SDHC SDHD | Colorectal polyposis |
| HP:0002331 | 0.00844485194452 | 0.5 | SDHC SDHD | Recurrent paroxysmal headache |
| HP:0012114 | 0.0092117244708 | 0.5 | SDHC SDHD | Endometrial carcinoma |
| HP:0011703 | 0.0092117244708 | 0.5 | SDHC SDHD | Sinus tachycardia |
| HP:0030670 | 0.0100118295947 | 0.5 | SDHC SDHD | Hamartoma of the orbital region |
| HP:0010568 | 0.0100118295947 | 0.5 | SDHC SDHD | Hamartoma of the eye |
| HP:0030126 | 0.0100118295947 | 0.5 | SDHC SDHD | Abnormal endometrium morphology |
| HP:0001069 | 0.0100118295947 | 0.5 | SDHC SDHD | Episodic hyperhidrosis |
| HP:0012032 | 0.0100118295947 | 0.5 | SDHC SDHD | Lipoma |
| HP:0012062 | 0.0108451581837 | 0.5 | SDHC SDHD | Bone cyst |
| HP:0009720 | 0.0108451581837 | 0.5 | SDHC SDHD | Adenoma sebaceum |
| HP:0002666 | 0.0108451581837 | 0.5 | SDHC SDHD | Pheochromocytoma |
| WP:WP111 | 0.0120322522645 | 0.5 | SDHC SDHD | Electron transport chain OXPHOS system in mitochondria |
| KEGG:01200 | 0.0133093129958 | 0.5 | SDHC SDHD | Carbon metabolism |
| REAC:R-HSA-71406 | 0.0135329645116 | 0.5 | SDHC SDHD | Pyruvate metabolism and Citric Acid (TCA) cycle |
| HP:0001048 | 0.0135443934278 | 0.5 | SDHC SDHD | Cavernous hemangioma |
| HP:0030255 | 0.0135443934278 | 0.5 | SDHC SDHD | Large intestinal polyposis |
| HP:0002574 | 0.0145105245688 | 0.5 | SDHC SDHD | Episodic abdominal pain |
| HP:0010615 | 0.0155098335254 | 0.5 | SDHC SDHD | Angiofibromas |
| HP:0000767 | 0.0156425362492 | 0.75 | SDHC DHODH SDHD | Pectus excavatum |
| HP:0005374 | 0.0165423111708 | 0.5 | SDHC SDHD | Cellular immunodeficiency |
| HP:0032148 | 0.0165423111708 | 0.5 | SDHC SDHD | Episodic pain |
| GO:0045273 | 0.0168521501606 | 0.5 | SDHC SDHD | respiratory chain complex II |
| GO:0045257 | 0.0168521501606 | 0.5 | SDHC SDHD | succinate dehydrogenase complex (ubiquinone) |
| GO:0045283 | 0.0168521501606 | 0.5 | SDHC SDHD | fumarate reductase complex |
| GO:0045281 | 0.0168521501606 | 0.5 | SDHC SDHD | succinate dehydrogenase complex |
| GO:0005749 | 0.0168521501606 | 0.5 | SDHC SDHD | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) |
| HP:0100530 | 0.0176079483787 | 0.5 | SDHC SDHD | Abnormal circulating calcium-phosphate regulating hormone concentration |
| KEGG:00190 | 0.0183110737362 | 0.5 | SDHC SDHD | Oxidative phosphorylation |
| HP:0100634 | 0.018706736024 | 0.5 | SDHC SDHD | Neuroendocrine neoplasm |
| HP:0000405 | 0.0206880734637 | 0.75 | SDHC DHODH SDHD | Conductive hearing impairment |
| HP:0011452 | 0.0217270761582 | 0.75 | SDHC DHODH SDHD | Functional abnormality of the middle ear |
| HP:0100579 | 0.0222019103471 | 0.5 | SDHC SDHD | Mucosal telangiectasiae |
| HP:0000221 | 0.0234332085093 | 0.5 | SDHC SDHD | Furrowed tongue |
| WP:WP4396 | 0.023499356813 | 0.5 | SDHC SDHD | Nonalcoholic fatty liver disease |
| KEGG:04932 | 0.0237566589162 | 0.5 | SDHC SDHD | Non-alcoholic fatty liver disease |
| HP:0000526 | 0.0246976114972 | 0.5 | SDHC SDHD | Aniridia |
| HP:0100631 | 0.0259951101914 | 0.5 | SDHC SDHD | Neoplasm of the adrenal gland |
| HP:0200013 | 0.0273256954732 | 0.5 | SDHC SDHD | Neoplasm of fatty tissue |
| HP:0002858 | 0.0273256954732 | 0.5 | SDHC SDHD | Meningioma |
| HP:0012031 | 0.0273256954732 | 0.5 | SDHC SDHD | Lipomatous tumor |
| GO:0006121 | 0.0280843539964 | 0.5 | SDHC SDHD | mitochondrial electron transport, succinate to ubiquinone |
| HP:0031801 | 0.03008608933 | 0.5 | SDHC SDHD | Vocal cord dysfunction |
| HP:0001293 | 0.03008608933 | 0.5 | SDHC SDHD | Cranial nerve compression |
| HP:0001605 | 0.03008608933 | 0.5 | SDHC SDHD | Vocal cord paralysis |
| HP:0100743 | 0.03008608933 | 0.5 | SDHC SDHD | Neoplasm of the rectum |
| HP:0100012 | 0.03008608933 | 0.5 | SDHC SDHD | Neoplasm of the eye |
| HP:0012740 | 0.0315158796726 | 0.5 | SDHC SDHD | Papilloma |
| HP:0031284 | 0.0315158796726 | 0.5 | SDHC SDHD | Flushing |
| HP:0000853 | 0.0329787201379 | 0.5 | SDHC SDHD | Goiter |
| HP:0002890 | 0.0391604009626 | 0.5 | SDHC SDHD | Thyroid carcinoma |
| KEGG:05415 | 0.0406374666322 | 0.5 | SDHC SDHD | Diabetic cardiomyopathy |
| HP:0025269 | 0.040788355352 | 0.5 | SDHC SDHD | Panic attack |
| HP:0031093 | 0.0410470782574 | 0.75 | SDHC DHODH SDHD | Abnormal breast morphology |
| HP:0000769 | 0.0420203461686 | 0.75 | SDHC DHODH SDHD | Abnormality of the breast |
| HP:0000766 | 0.0453746914491 | 0.75 | SDHC DHODH SDHD | Abnormal sternum morphology |
| HP:0000360 | 0.0476300363671 | 0.5 | SDHC SDHD | Tinnitus |
| REAC:R-HSA-611105 | 0.0492961191682 | 0.5 | SDHC SDHD | Respiratory electron transport |
| KEGG:05208 | 0.049994875911 | 0.5 | SDHC SDHD | Chemical carcinogenesis - reactive oxygen species |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| DHODH | TMEM95 | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SDHC | SDHD | 0.998 | 0.922 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| DHODH | SDHD | 0.998 | 0.122 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| SDHC | DHODH | 0.987 | 0.086 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| TMEM95 | SDHD | 0.977 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| SDHC | huMAP3_03912.1 huMAP3_03953.1 huMAP3_07875.1 huMAP3_12069.1 |
| DHODH | huMAP3_03912.1 huMAP3_03953.1 huMAP3_12069.1 |
| TMEM95 | huMAP3_03912.1 huMAP3_12069.1 |
| SDHD | huMAP3_03912.1 huMAP3_03953.1 huMAP3_12069.1 |