hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03925.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CXCL1 | Growth-regulated alpha protein (C-X-C motif chemokine 1) (GRO-alpha(1-73)) (Melanoma growth stimulatory activity) (MGSA) (Neutrophil-activating protein 3) (NAP-3) [Cleaved into: GRO-alpha(4-73); GRO-alpha(5-73); GRO-alpha(6-73)] | 5 | UniProt NCBI |
| BIRC3 | Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (RING-type E3 ubiquitin transferase BIRC3) (TNFR2-TRAF-signaling complex protein 1) | 5 | UniProt NCBI |
| HTRA2 | Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI) | 5 | UniProt NCBI |
| TANK | TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF) | 5 | UniProt NCBI |
| TRAF2 | TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3) | 5 | UniProt NCBI |
| TBK1 | Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1) | 5 | UniProt NCBI |
| TRAF1 | TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6) | 5 | UniProt NCBI |
| IKBKE | Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04621 | 1.22242614927e-09 | 0.75 | IKBKE TBK1 TRAF2 BIRC3 CXCL1 TANK | NOD-like receptor signaling pathway |
| REAC:R-HSA-5357905 | 2.31476040783e-09 | 0.625 | TRAF1 BIRC3 IKBKE TRAF2 TBK1 | Regulation of TNFR1 signaling |
| REAC:R-HSA-75893 | 6.1071250098e-09 | 0.625 | TRAF1 BIRC3 IKBKE TRAF2 TBK1 | TNF signaling |
| GO:0071345 | 2.73507075478e-08 | 1.0 | IKBKE TBK1 HTRA2 TRAF1 TRAF2 BIRC3 CXCL1 TANK | cellular response to cytokine stimulus |
| WP:WP231 | 2.80248370233e-08 | 0.625 | TRAF1 BIRC3 TBK1 TANK TRAF2 | TNF alpha signaling pathway |
| GO:0034097 | 7.06888625491e-08 | 1.0 | IKBKE TBK1 HTRA2 TRAF1 TRAF2 BIRC3 CXCL1 TANK | response to cytokine |
| REAC:R-HSA-5357786 | 8.29203003935e-08 | 0.5 | BIRC3 IKBKE TRAF2 TBK1 | TNFR1-induced proapoptotic signaling |
| REAC:R-HSA-168164 | 9.83247470733e-08 | 0.625 | BIRC3 TBK1 IKBKE TANK TRAF2 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-166166 | 1.09845520895e-07 | 0.625 | BIRC3 TBK1 IKBKE TANK TRAF2 | MyD88-independent TLR4 cascade |
| REAC:R-HSA-937061 | 1.09845520895e-07 | 0.625 | BIRC3 TBK1 IKBKE TANK TRAF2 | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-933541 | 1.85138533847e-07 | 0.5 | TBK1 IKBKE TANK TRAF2 | TRAF6 mediated IRF7 activation |
| REAC:R-HSA-166016 | 4.543329189e-07 | 0.625 | BIRC3 TBK1 IKBKE TANK TRAF2 | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-73887 | 5.34204515762e-07 | 0.625 | TRAF1 BIRC3 IKBKE TRAF2 TBK1 | Death Receptor Signaling |
| CORUM:5212 | 5.49353690762e-07 | 0.375 | TBK1 TANK TRAF2 | Kinase maturation complex 2 |
| KEGG:05417 | 7.21279918769e-07 | 0.625 | CXCL1 TBK1 IKBKE TANK TRAF2 | Lipid and atherosclerosis |
| WP:WP5039 | 9.00407069487e-07 | 0.5 | CXCL1 TBK1 TANK TRAF2 | SARS CoV 2 innate immunity evasion and cell specific immune response |
| REAC:R-HSA-168898 | 9.39081445557e-07 | 0.625 | BIRC3 TBK1 IKBKE TANK TRAF2 | Toll-like Receptor Cascades |
| WP:WP3865 | 1.05136071493e-06 | 0.5 | TBK1 IKBKE TANK TRAF2 | Novel intracellular components of RIG I like receptor pathway |
| GO:0019221 | 1.10251630201e-06 | 0.875 | IKBKE TBK1 TRAF1 TRAF2 BIRC3 CXCL1 TANK | cytokine-mediated signaling pathway |
| KEGG:04622 | 1.21827180925e-06 | 0.5 | TBK1 IKBKE TANK TRAF2 | RIG-I-like receptor signaling pathway |
| KEGG:04657 | 2.42868259593e-06 | 0.5 | CXCL1 IKBKE TRAF2 TBK1 | IL-17 signaling pathway |
| KEGG:04064 | 2.83654365515e-06 | 0.5 | TRAF1 CXCL1 TRAF2 BIRC3 | NF-kappa B signaling pathway |
| REAC:R-HSA-9013973 | 5.02751533314e-06 | 0.375 | TBK1 TANK IKBKE | TICAM1-dependent activation of IRF3/IRF7 |
| KEGG:04668 | 5.69084438069e-06 | 0.5 | TRAF1 CXCL1 TRAF2 BIRC3 | TNF signaling pathway |
| REAC:R-HSA-936964 | 8.313982098e-06 | 0.375 | TBK1 TANK IKBKE | Activation of IRF3, IRF7 mediated by TBK1, IKBKE |
| REAC:R-HSA-168928 | 9.3792090956e-06 | 0.5 | TBK1 IKBKE TANK TRAF2 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| GO:0043122 | 1.22066097626e-05 | 0.75 | IKBKE BIRC3 TRAF1 TRAF2 TBK1 TANK | regulation of canonical NF-kappaB signal transduction |
| KEGG:04210 | 1.46036227458e-05 | 0.5 | TRAF1 BIRC3 HTRA2 TRAF2 | Apoptosis |
| GO:0007249 | 2.26794633463e-05 | 0.75 | IKBKE BIRC3 TRAF1 TRAF2 TBK1 TANK | canonical NF-kappaB signal transduction |
| GO:0071310 | 4.81292748009e-05 | 1.0 | IKBKE TBK1 HTRA2 TRAF1 TRAF2 BIRC3 CXCL1 TANK | cellular response to organic substance |
| KEGG:05167 | 5.63229714027e-05 | 0.5 | CXCL1 IKBKE TRAF2 TBK1 | Kaposi sarcoma-associated herpesvirus infection |
| WP:WP2036 | 6.95406701237e-05 | 0.375 | BIRC3 TRAF2 TRAF1 | TNF related weak inducer of apoptosis TWEAK signaling pathway |
| CORUM:5210 | 7.17483486175e-05 | 0.25 | TANK TRAF2 | TANK-TRAF2-TRAF3 complex |
| REAC:R-HSA-5357956 | 0.000112766844535 | 0.375 | BIRC3 TRAF2 TRAF1 | TNFR1-induced NF-kappa-B signaling pathway |
| REAC:R-HSA-168249 | 0.000265284467152 | 0.75 | IKBKE TBK1 TRAF2 BIRC3 CXCL1 TANK | Innate Immune System |
| GO:0010033 | 0.000328674397078 | 1.0 | IKBKE TBK1 HTRA2 TRAF1 TRAF2 BIRC3 CXCL1 TANK | response to organic substance |
| KEGG:05222 | 0.000533899657075 | 0.375 | BIRC3 TRAF2 TRAF1 | Small cell lung cancer |
| WP:WP254 | 0.000600026967084 | 0.375 | BIRC3 TRAF2 TRAF1 | Apoptosis |
| WP:WP5116 | 0.000668735194034 | 0.25 | TBK1 IKBKE | SARS CoV 2 B 1 1 7 variant antagonises innate immune activation |
| GO:0070887 | 0.000837649485178 | 1.0 | IKBKE TBK1 HTRA2 TRAF1 TRAF2 BIRC3 CXCL1 TANK | cellular response to chemical stimulus |
| WP:WP4658 | 0.00109108919451 | 0.375 | BIRC3 TRAF2 TRAF1 | Small cell lung cancer |
| KEGG:05168 | 0.00125152052582 | 0.5 | BIRC3 IKBKE TRAF2 TBK1 | Herpes simplex virus 1 infection |
| KEGG:04936 | 0.00160212912447 | 0.375 | CXCL1 IKBKE TBK1 | Alcoholic liver disease |
| GO:0007166 | 0.00177183690053 | 1.0 | IKBKE TBK1 HTRA2 TRAF1 TRAF2 BIRC3 CXCL1 TANK | cell surface receptor signaling pathway |
| KEGG:05160 | 0.00188812744317 | 0.375 | TBK1 TRAF2 IKBKE | Hepatitis C |
| KEGG:05022 | 0.00200923702547 | 0.5 | TBK1 HTRA2 TRAF2 TANK | Pathways of neurodegeneration - multiple diseases |
| WP:WP5182 | 0.00216982178847 | 0.25 | BIRC3 TRAF2 | Pro survival signaling of neuroprotectin D1 |
| CORUM:6344 | 0.00216982178847 | 0.25 | BIRC3 TRAF2 | TNF-R1-associated signaling complex |
| GO:0035556 | 0.00268170503809 | 1.0 | IKBKE TBK1 HTRA2 TRAF1 TRAF2 BIRC3 CXCL1 TANK | intracellular signal transduction |
| REAC:R-HSA-5676594 | 0.0030606580132 | 0.25 | BIRC3 TRAF2 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway |
| WP:WP4961 | 0.00364416819939 | 0.25 | TBK1 IKBKE | STING pathway in Kawasaki like disease and COVID 19 |
| KEGG:05169 | 0.00486719923682 | 0.375 | TBK1 TRAF2 IKBKE | Epstein-Barr virus infection |
| REAC:R-HSA-918233 | 0.00505983974502 | 0.25 | TBK1 IKBKE | TRAF3-dependent IRF activation pathway |
| KEGG:04215 | 0.00523098995231 | 0.25 | BIRC3 HTRA2 | Apoptosis - multiple species |
| GO:0042221 | 0.00595458932146 | 1.0 | IKBKE TBK1 HTRA2 TRAF1 TRAF2 BIRC3 CXCL1 TANK | response to chemical |
| WP:WP4868 | 0.00601773204474 | 0.25 | TBK1 IKBKE | Type I interferon induction and signaling during SARS CoV 2 infection |
| WP:WP3851 | 0.00713174328203 | 0.25 | TBK1 IKBKE | TLR4 signaling and tolerance |
| WP:WP5115 | 0.00770221928581 | 0.375 | CXCL1 TRAF2 TBK1 | Network map of SARS CoV 2 signaling pathway |
| WP:WP4950 | 0.0077239395488 | 0.25 | TRAF1 TRAF2 | 16p11 2 distal deletion syndrome |
| WP:WP3858 | 0.00833957037235 | 0.25 | TBK1 IKBKE | Toll like receptor signaling related to MyD88 |
| WP:WP5406 | 0.00897861635867 | 0.25 | TRAF1 TRAF2 | 13q12 12 copy number variation |
| WP:WP4880 | 0.00964105812378 | 0.25 | TBK1 IKBKE | Host pathogen interaction of human coronaviruses interferon induction |
| WP:WP5038 | 0.00964105812378 | 0.25 | TBK1 IKBKE | Mitochondrial immune response to SARS CoV 2 |
| GO:1902531 | 0.010312469237 | 0.875 | IKBKE BIRC3 HTRA2 TRAF1 TRAF2 TBK1 TANK | regulation of intracellular signal transduction |
| WP:WP4912 | 0.0103268762936 | 0.25 | TBK1 IKBKE | SARS coronavirus and innate immunity |
| GO:0140546 | 0.0105521760717 | 0.75 | IKBKE TBK1 TRAF2 BIRC3 CXCL1 TANK | defense response to symbiont |
| REAC:R-HSA-168256 | 0.0113619114179 | 0.75 | IKBKE TBK1 TRAF2 BIRC3 CXCL1 TANK | Immune System |
| WP:WP3941 | 0.0149316061259 | 0.25 | TRAF1 TRAF2 | Oxidative damage response |
| GO:0098542 | 0.0165770921533 | 0.75 | IKBKE TBK1 TRAF2 BIRC3 CXCL1 TANK | defense response to other organism |
| GO:0071356 | 0.0197287134506 | 0.5 | TRAF1 BIRC3 TANK TRAF2 | cellular response to tumor necrosis factor |
| REAC:R-HSA-5213460 | 0.0240813966337 | 0.25 | BIRC3 TRAF2 | RIPK1-mediated regulated necrosis |
| REAC:R-HSA-5675482 | 0.0240813966337 | 0.25 | BIRC3 TRAF2 | Regulation of necroptotic cell death |
| WP:WP2018 | 0.0244633875231 | 0.25 | TRAF1 TRAF2 | RANKL RANK signaling pathway |
| KEGG:05014 | 0.0275508352385 | 0.375 | TBK1 TANK TRAF2 | Amyotrophic lateral sclerosis |
| REAC:R-HSA-936440 | 0.02920582473 | 0.25 | TBK1 IKBKE | Negative regulators of DDX58/IFIH1 signaling |
| GO:0034612 | 0.0306827893089 | 0.5 | TRAF1 BIRC3 TANK TRAF2 | response to tumor necrosis factor |
| KEGG:04623 | 0.0307677963901 | 0.25 | TBK1 IKBKE | Cytosolic DNA-sensing pathway |
| REAC:R-HSA-162582 | 0.0324681032361 | 0.75 | IKBKE TBK1 TRAF1 TRAF2 BIRC3 CXCL1 | Signal Transduction |
| REAC:R-HSA-9692916 | 0.0388325640363 | 0.25 | TBK1 IKBKE | SARS-CoV-1 activates/modulates innate immune responses |
| REAC:R-HSA-1280215 | 0.0388837771011 | 0.5 | CXCL1 TBK1 TRAF2 BIRC3 | Cytokine Signaling in Immune system |
| GO:0051707 | 0.0458444123506 | 0.75 | IKBKE TBK1 TRAF2 BIRC3 CXCL1 TANK | response to other organism |
| GO:0043207 | 0.0458444123506 | 0.75 | IKBKE TBK1 TRAF2 BIRC3 CXCL1 TANK | response to external biotic stimulus |
| KEGG:04620 | 0.0474398326563 | 0.25 | TBK1 IKBKE | Toll-like receptor signaling pathway |
| WP:WP4655 | 0.0489078463283 | 0.25 | TBK1 IKBKE | Cytosolic DNA sensing pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TRAF2 | TRAF1 | 1.0 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TANK | TRAF1 | 0.999 | 0.136 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TANK | TRAF2 | 0.999 | 0.148952380952 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TRAF1 | TBK1 | 0.999 | 0.124 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TANK | TBK1 | 0.998 | 0.194 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| TRAF2 | TBK1 | 0.998 | 0.06 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| HTRA2 | TRAF2 | 0.994 | 0.034 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| CXCL1 | TRAF2 | 0.987 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CXCL1 | TBK1 | 0.984 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TANK | IKBKE | 0.98 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| HTRA2 | TRAF1 | 0.98 | 0.092 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TRAF2 | IKBKE | 0.976 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| BIRC3 | TRAF2 | 0.969 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| BIRC3 | TRAF1 | 0.966 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| HTRA2 | TANK | 0.952 | 0.096 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| BIRC3 | IKBKE | 0.892 | bioplex3_WMM WMM_only | |
| TRAF1 | IKBKE | 0.796 | bioplex3_WMM WMM_only | |
| IKBKE | TBK1 | 0.456 | bioplex3_WMM WMM_only | |
| HTRA2 | IKBKE | 0.451 | bioplex3_WMM WMM_only | |
| BIRC3 | TANK | 0.384 | bioplex3_WMM WMM_only | |
| BIRC3 | TBK1 | 0.373 | bioplex3_WMM WMM_only | |
| BIRC3 | HTRA2 | 0.306 | bioplex3_WMM WMM_only | |
| HTRA2 | TBK1 | 0.277 | 0.042 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| CXCL1 | TANK | 0.043 | bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes