List of Gene Names or Uniprot ACCs (ex. OFD1 PCM1 Q1MSJ5):

Enrichment (ex. cilium):

Protein (ex. Centrosomal protein):

Complex: huMAP3_03927.1

Confidence: Extremely High   ?

Proteins

Genename	Protein Name	Uniprot Annotation Score	Links
NOTCH3	Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain]	5	UniProt   NCBI
MAML1	Mastermind-like protein 1 (Mam-1)	5	UniProt   NCBI
HGF	Hepatocyte growth factor (Hepatopoietin-A) (Scatter factor) (SF) [Cleaved into: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain]	5	UniProt   NCBI
WNT10A	Protein Wnt-10a	5	UniProt   NCBI
CCN6	Cellular communication network factor 6 (CCN family member 6) (WNT1-inducible-signaling pathway protein 3) (WISP-3)	5	UniProt   NCBI
NOTCH1	Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]	5	UniProt   NCBI
RBPJ	Recombining binding protein suppressor of hairless (CBF-1) (J kappa-recombination signal-binding protein) (RBP-J kappa) (RBP-J) (RBP-JK) (Renal carcinoma antigen NY-REN-30)	5	UniProt   NCBI
NOTCH2	Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)]	5	UniProt   NCBI



Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP3845	3.97690930474e-12	0.714285714286	RBPJ MAML1 NOTCH2 NOTCH3 NOTCH1	Canonical and non canonical Notch signaling
REAC:R-HSA-350054	1.92631854374e-11	0.714285714286	RBPJ MAML1 NOTCH2 NOTCH3 NOTCH1	Notch-HLH transcription pathway
KEGG:04330	3.36322590815e-10	0.714285714286	RBPJ MAML1 NOTCH2 NOTCH3 NOTCH1	Notch signaling pathway
WP:WP61	3.70367827245e-10	0.714285714286	RBPJ MAML1 NOTCH2 NOTCH3 NOTCH1	Notch signaling pathway
KEGG:04658	3.15460669646e-09	0.714285714286	RBPJ MAML1 NOTCH2 NOTCH3 NOTCH1	Th1 and Th2 cell differentiation
REAC:R-HSA-9013695	4.86362738832e-09	0.571428571429	MAML1 NOTCH2 RBPJ NOTCH1	NOTCH4 Intracellular Domain Regulates Transcription
CORUM:3113	7.02338504734e-09	0.428571428571	MAML1 RBPJ NOTCH1	RBPJ-NOTCH1-MAML1 complex
CORUM:2897	7.02338504734e-09	0.428571428571	MAML1 RBPJ NOTCH1	RBPJ-NOTCH1-MAML1 complex
CORUM:2890	7.02338504734e-09	0.428571428571	MAML1 RBPJ NOTCH1	RBPJ-NOTCH1-MAML1 complex
REAC:R-HSA-1912408	1.34310515544e-08	0.714285714286	RBPJ MAML1 NOTCH2 NOTCH3 NOTCH1	Pre-NOTCH Transcription and Translation
REAC:R-HSA-9013508	1.72490220596e-08	0.571428571429	RBPJ MAML1 NOTCH3 NOTCH1	NOTCH3 Intracellular Domain Regulates Transcription
KEGG:05165	2.26329306696e-08	0.857142857143	NOTCH3 NOTCH1 MAML1 RBPJ NOTCH2 WNT10A	Human papillomavirus infection
WP:WP4787	2.82174229483e-08	0.714285714286	RBPJ NOTCH1 NOTCH2 NOTCH3 WNT10A	Osteoblast differentiation and related diseases
REAC:R-HSA-1912422	3.5685870487e-08	0.714285714286	RBPJ MAML1 NOTCH2 NOTCH3 NOTCH1	Pre-NOTCH Expression and Processing
REAC:R-HSA-5083630	5.21474531955e-08	0.428571428571	NOTCH1 NOTCH3 NOTCH2	Defective LFNG causes SCDO3
WP:WP268	9.77598775957e-08	0.571428571429	MAML1 NOTCH2 NOTCH3 NOTCH1	Notch signaling
WP:WP4239	1.04430456257e-07	0.714285714286	RBPJ NOTCH1 NOTCH2 NOTCH3 WNT10A	Epithelial to mesenchymal transition in colorectal cancer
REAC:R-HSA-1912399	1.30341865814e-07	0.428571428571	NOTCH1 NOTCH3 NOTCH2	Pre-NOTCH Processing in the Endoplasmic Reticulum
REAC:R-HSA-9012852	2.91913824823e-07	0.571428571429	RBPJ MAML1 NOTCH3 NOTCH1	Signaling by NOTCH3
REAC:R-HSA-2197563	4.56009206293e-07	0.428571428571	MAML1 RBPJ NOTCH2	NOTCH2 intracellular domain regulates transcription
WP:WP3971	7.30297581269e-07	0.428571428571	NOTCH1 NOTCH3 NOTCH2	OSX and miRNAs in tooth development
CORUM:2639	1.54229147311e-06	0.428571428571	MAML1 RBPJ NOTCH1	HES1 promoter-Notch enhancer complex
WP:WP2064	1.89768773515e-06	0.571428571429	NOTCH1 NOTCH2 NOTCH3 RBPJ	Neural crest differentiation
REAC:R-HSA-157118	2.00753073726e-06	0.714285714286	RBPJ MAML1 NOTCH2 NOTCH3 NOTCH1	Signaling by NOTCH
REAC:R-HSA-210744	2.1479923589e-06	0.428571428571	MAML1 RBPJ NOTCH1	Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
REAC:R-HSA-8941856	2.1479923589e-06	0.428571428571	MAML1 RBPJ NOTCH1	RUNX3 regulates NOTCH signaling
GO:0002193	3.36420143768e-06	0.428571428571	MAML1 RBPJ NOTCH1	MAML1-RBP-Jkappa- ICN1 complex
GO:0007221	3.36420143768e-06	0.428571428571	MAML1 RBPJ NOTCH1	positive regulation of transcription of Notch receptor target
REAC:R-HSA-9013694	3.84133367584e-06	0.571428571429	MAML1 NOTCH2 RBPJ NOTCH1	Signaling by NOTCH4
GO:0007219	5.78516855405e-06	0.714285714286	RBPJ MAML1 NOTCH2 NOTCH3 NOTCH1	Notch signaling pathway
REAC:R-HSA-1912420	8.84142817265e-06	0.428571428571	NOTCH1 NOTCH3 NOTCH2	Pre-NOTCH Processing in Golgi
KEGG:05224	9.73552510533e-06	0.571428571429	NOTCH1 NOTCH2 NOTCH3 WNT10A	Breast cancer
REAC:R-HSA-9793380	1.06075342669e-05	0.428571428571	MAML1 RBPJ NOTCH1	Formation of paraxial mesoderm
WP:WP4262	2.0346480611e-05	0.571428571429	NOTCH1 NOTCH2 NOTCH3 WNT10A	Breast cancer pathway
CORUM:2907	2.05265451394e-05	0.285714285714	NOTCH1 RBPJ	RBP-Jkappa-Notch1 complex
CORUM:2946	2.05265451394e-05	0.285714285714	NOTCH1 RBPJ	YY1-Notch1-RBP-Jkappa complex
REAC:R-HSA-1980145	2.62784267685e-05	0.428571428571	MAML1 RBPJ NOTCH2	Signaling by NOTCH2
REAC:R-HSA-186712	2.98557123546e-05	0.428571428571	MAML1 RBPJ NOTCH1	Regulation of beta-cell development
REAC:R-HSA-9758941	0.000100611892471	0.428571428571	MAML1 RBPJ NOTCH1	Gastrulation
REAC:R-HSA-2122947	0.000127854887848	0.428571428571	MAML1 RBPJ NOTCH1	NOTCH1 Intracellular Domain Regulates Transcription
REAC:R-HSA-3906995	0.00014849904315	0.428571428571	NOTCH1 NOTCH3 NOTCH2	Diseases associated with O-glycosylation of proteins
REAC:R-HSA-2644603	0.000209532838622	0.428571428571	MAML1 RBPJ NOTCH1	Signaling by NOTCH1 in Cancer
REAC:R-HSA-2644606	0.000209532838622	0.428571428571	MAML1 RBPJ NOTCH1	Constitutive Signaling by NOTCH1 PEST Domain Mutants
REAC:R-HSA-2894862	0.000209532838622	0.428571428571	MAML1 RBPJ NOTCH1	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
REAC:R-HSA-2894858	0.000209532838622	0.428571428571	MAML1 RBPJ NOTCH1	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
REAC:R-HSA-2644602	0.000209532838622	0.428571428571	MAML1 RBPJ NOTCH1	Signaling by NOTCH1 PEST Domain Mutants in Cancer
WP:WP2840	0.000262838994257	0.428571428571	NOTCH1 RBPJ NOTCH2	Hair follicle development cytodifferentiation part 3 of 3
KEGG:01522	0.000305983503712	0.428571428571	NOTCH1 NOTCH3 NOTCH2	Endocrine resistance
WP:WP4674	0.000329052287544	0.428571428571	MAML1 NOTCH2 NOTCH1	Head and neck squamous cell carcinoma
REAC:R-HSA-1980143	0.000419050615628	0.428571428571	MAML1 RBPJ NOTCH1	Signaling by NOTCH1
HP:0001231	0.000452550360828	0.571428571429	NOTCH1 NOTCH2 WNT10A RBPJ	Abnormal fingernail morphology
WP:WP4147	0.000640208164062	0.285714285714	NOTCH1 RBPJ	PTF1A related regulatory pathway
KEGG:04919	0.000644629847358	0.428571428571	NOTCH1 NOTCH3 NOTCH2	Thyroid hormone signaling pathway
GO:0003205	0.00123140499228	0.571428571429	MAML1 NOTCH2 RBPJ NOTCH1	cardiac chamber development
HP:0008386	0.0013049791219	0.571428571429	NOTCH1 NOTCH2 WNT10A RBPJ	Aplasia/Hypoplasia of the nails
HP:0001798	0.00132210183309	0.428571428571	NOTCH1 WNT10A RBPJ	Anonychia
REAC:R-HSA-8878159	0.00140610739888	0.428571428571	MAML1 RBPJ NOTCH1	Transcriptional regulation by RUNX3
KEGG:05200	0.00145294754856	0.571428571429	NOTCH1 NOTCH2 NOTCH3 WNT10A	Pathways in cancer
HP:0010760	0.00148002522626	0.428571428571	NOTCH1 RBPJ NOTCH2	Absent toe
KEGG:05206	0.00180438218152	0.428571428571	NOTCH1 NOTCH3 NOTCH2	MicroRNAs in cancer
GO:0003177	0.00273674384085	0.428571428571	NOTCH1 RBPJ NOTCH2	pulmonary valve development
REAC:R-HSA-3781865	0.00290605023767	0.428571428571	NOTCH1 NOTCH3 NOTCH2	Diseases of glycosylation
GO:0048738	0.00385096114287	0.571428571429	MAML1 NOTCH2 RBPJ NOTCH1	cardiac muscle tissue development
GO:0014706	0.004672681336	0.571428571429	MAML1 NOTCH2 RBPJ NOTCH1	striated muscle tissue development
HP:0001269	0.00534336634934	0.428571428571	NOTCH1 NOTCH3 RBPJ	Hemiparesis
HP:0011355	0.00554811459408	0.714285714286	RBPJ NOTCH1 NOTCH2 NOTCH3 WNT10A	Localized skin lesion
REAC:R-HSA-212436	0.00607059142443	0.714285714286	RBPJ MAML1 NOTCH2 NOTCH3 NOTCH1	Generic Transcription Pathway
HP:0006493	0.00635143461582	0.571428571429	CCN6 NOTCH2 RBPJ NOTCH1	Aplasia/hypoplasia involving bones of the lower limbs
WP:WP5269	0.00718724508234	0.285714285714	NOTCH1 RBPJ	Genetic causes of porto sinusoidal vascular disease
REAC:R-HSA-162582	0.00838328139233	0.857142857143	NOTCH3 NOTCH1 MAML1 RBPJ NOTCH2 WNT10A	Signal Transduction
HP:0009882	0.00876868087469	0.428571428571	NOTCH1 RBPJ NOTCH2	Short distal phalanx of finger
WP:WP4331	0.00877446561805	0.285714285714	NOTCH1 NOTCH3	Neovascularisation processes
HP:0000238	0.00905879972047	0.571428571429	NOTCH1 NOTCH2 NOTCH3 RBPJ	Hydrocephalus
HP:0001799	0.00914682299331	0.285714285714	NOTCH2 WNT10A	Short nail
HP:0009835	0.010170078975	0.428571428571	NOTCH1 RBPJ NOTCH2	Aplasia/Hypoplasia of the distal phalanges of the hand
REAC:R-HSA-73857	0.0103732213005	0.714285714286	RBPJ MAML1 NOTCH2 NOTCH3 NOTCH1	RNA Polymerase II Transcription
HP:0001991	0.0104670405724	0.428571428571	NOTCH1 RBPJ NOTCH2	Aplasia/Hypoplasia of toe
HP:0030966	0.0127078129037	0.428571428571	NOTCH1 RBPJ NOTCH2	Abnormal pulmonary artery morphology
HP:0032263	0.0133422947	0.571428571429	NOTCH1 NOTCH2 NOTCH3 RBPJ	Increased blood pressure
REAC:R-HSA-5668914	0.0134637920212	0.428571428571	NOTCH1 NOTCH3 NOTCH2	Diseases of metabolism
HP:0004414	0.0160267107767	0.428571428571	NOTCH1 RBPJ NOTCH2	Abnormality of the pulmonary artery
GO:1905314	0.016587316136	0.428571428571	NOTCH1 RBPJ NOTCH2	semi-lunar valve development
REAC:R-HSA-74160	0.0190899982826	0.714285714286	RBPJ MAML1 NOTCH2 NOTCH3 NOTCH1	Gene expression (Transcription)
HP:0001597	0.0198728250032	0.571428571429	NOTCH1 NOTCH2 WNT10A RBPJ	Abnormality of the nail
GO:0051149	0.0218744047191	0.428571428571	MAML1 NOTCH2 NOTCH1	positive regulation of muscle cell differentiation
HP:0030972	0.0219683118616	0.571428571429	NOTCH1 NOTCH2 NOTCH3 RBPJ	Abnormal systemic blood pressure
HP:0004050	0.0225866527703	0.285714285714	NOTCH1 RBPJ	Absent hand
HP:0002691	0.0225866527703	0.285714285714	NOTCH2 NOTCH3	Platybasia
HP:0008388	0.024284645806	0.428571428571	NOTCH1 WNT10A RBPJ	Abnormal toenail morphology
HP:0011603	0.0244362415094	0.571428571429	NOTCH1 NOTCH2 NOTCH3 RBPJ	Congenital malformation of the great arteries
HP:0009832	0.0248113027549	0.428571428571	NOTCH1 RBPJ NOTCH2	Abnormal distal phalanx morphology of finger
HP:0001810	0.0283864349721	0.285714285714	NOTCH1 WNT10A	Dystrophic toenail
GO:0060537	0.0293914725345	0.571428571429	MAML1 NOTCH2 RBPJ NOTCH1	muscle tissue development
HP:0009115	0.0294473474739	0.714285714286	RBPJ CCN6 NOTCH2 NOTCH3 NOTCH1	Aplasia/hypoplasia involving the skeleton
HP:0001792	0.030497900705	0.428571428571	NOTCH1 WNT10A RBPJ	Small nail
HP:0001718	0.0315332858987	0.285714285714	NOTCH1 NOTCH2	Mitral stenosis
REAC:R-HSA-1643685	0.0367346572641	0.714285714286	RBPJ MAML1 NOTCH2 NOTCH3 NOTCH1	Disease
HP:0009803	0.0390924259164	0.428571428571	NOTCH1 RBPJ NOTCH2	Short phalanx of finger
HP:0001636	0.0398126266618	0.428571428571	NOTCH1 RBPJ NOTCH2	Tetralogy of Fallot
HP:0040064	0.0399668993323	0.857142857143	CCN6 NOTCH3 NOTCH1 RBPJ NOTCH2 WNT10A	Abnormality of limbs
HP:0010719	0.0427808213716	0.428571428571	NOTCH2 NOTCH3 WNT10A	Abnormality of hair texture
HP:0001595	0.0434621805893	0.714285714286	RBPJ NOTCH1 NOTCH2 NOTCH3 WNT10A	Abnormal hair morphology
HP:0002921	0.0451244081745	0.571428571429	NOTCH1 NOTCH2 NOTCH3 RBPJ	Abnormal cerebrospinal fluid morphology
HP:0004586	0.0457644476584	0.285714285714	NOTCH2 NOTCH3	Biconcave vertebral bodies
HP:0001362	0.0497326121949	0.285714285714	NOTCH1 RBPJ	Calvarial skull defect
HP:0003396	0.0497326121949	0.285714285714	NOTCH2 NOTCH3	Syringomyelia
CORUM:2947	0.0499958217778	0.142857142857	NOTCH1	YY1-Notch1 complex



Edges

Protein 1	Protein 2	Score ?	ProteomeHD?	Evidence ?
MAML1	RBPJ	0.998	0.076	hein_WMM     bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     hein ()
RBPJ	NOTCH2	0.996	0.046	hein_WMM     bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     hein ()
NOTCH3	WNT10A	0.987		bioplex3_WMM     bioplex3_HCT116     WMM_only
MAML1	NOTCH2	0.986	0.124	hein_WMM     bioplex_WMM     bioplex3_WMM     WMM_only
NOTCH1	NOTCH2	0.981	0.096	hein_WMM     bioplex_WMM     bioplex3_WMM     gupta_WMM     WMM_only
NOTCH1	RBPJ	0.98	0.084	hein_WMM     bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     hein ()
NOTCH3	NOTCH1	0.98	0.166	bioplex_WMM     bioplex3_WMM     gupta_WMM     WMM_only
MAML1	NOTCH1	0.979	0.166	hein_WMM     bioplex_WMM     bioplex3_WMM     WMM_only
NOTCH3	NOTCH2	0.979	0.16	bioplex3_HEK293     bioplex_WMM     bioplex3_WMM     gupta_WMM     WMM_only
CCN6	NOTCH1	0.972		bioplex3_WMM     bioplex3_HCT116     WMM_only
HGF	NOTCH1	0.968		bioplex3_WMM     bioplex3_HCT116     WMM_only
WNT10A	NOTCH2	0.964		bioplex3_WMM     bioplex3_HCT116     WMM_only
CCN6	NOTCH2	0.963		bioplex3_WMM     bioplex3_HCT116     WMM_only
WNT10A	NOTCH1	0.962		bioplex3_WMM     bioplex3_HCT116     WMM_only
NOTCH3	RBPJ	0.76	0.126	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM
NOTCH3	MAML1	0.186	0.174	bioplex_WMM     bioplex3_WMM     WMM_only
HGF	NOTCH2	0.014		youn_WMM     WMM_only





Related Complexes

Genename	Complexes
NOTCH3	huMAP3_00479.1 huMAP3_03927.1 huMAP3_14676.1
MAML1	huMAP3_03927.1 huMAP3_05007.1 huMAP3_11188.1 huMAP3_12765.1 huMAP3_13515.1 huMAP3_14658.1 huMAP3_14676.1 huMAP3_14883.1 huMAP3_15111.1 huMAP3_15115.1
HGF	huMAP3_03107.1 huMAP3_03927.1 huMAP3_12069.1
WNT10A	huMAP3_00479.1 huMAP3_01505.1 huMAP3_03071.1 huMAP3_03927.1 huMAP3_08544.1 huMAP3_09818.1 huMAP3_10711.1 huMAP3_12700.1 huMAP3_14676.1
CCN6	huMAP3_03927.1 huMAP3_04320.1 huMAP3_06797.1 huMAP3_11188.1 huMAP3_14676.1
NOTCH1	huMAP3_03927.1 huMAP3_11188.1 huMAP3_14658.1 huMAP3_14676.1
RBPJ	huMAP3_03927.1 huMAP3_05007.1 huMAP3_11188.1 huMAP3_14658.1 huMAP3_14676.1
NOTCH2	huMAP3_03927.1 huMAP3_11188.1 huMAP3_14676.1