hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03931.1
Complex Portal: CPX-21945
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SLC2A8 | Solute carrier family 2, facilitated glucose transporter member 8 (Glucose transporter type 8) (GLUT-8) (Glucose transporter type X1) | 5 | UniProt NCBI |
| TRAK1 | Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase-interacting protein) (Protein Milton) | 5 | UniProt NCBI |
| SAMM50 | Sorting and assembly machinery component 50 homolog (Transformation-related gene 3 protein) (TRG-3) | 5 | UniProt NCBI |
| IMMT | MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) | 5 | UniProt NCBI |
| MTX2 | Metaxin-2 (Mitochondrial outer membrane import complex protein 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6249 | 3.36038420171e-07 | 0.6 | SAMM50 IMMT MTX2 | MIB complex |
| REAC:R-HSA-8949613 | 1.26352756558e-05 | 0.6 | SAMM50 IMMT MTX2 | Cristae formation |
| GO:0001401 | 0.000211268761872 | 0.6 | SAMM50 IMMT MTX2 | SAM complex |
| GO:0140275 | 0.000211268761872 | 0.6 | SAMM50 IMMT MTX2 | MIB complex |
| REAC:R-HSA-1592230 | 0.00031666554152 | 0.6 | SAMM50 IMMT MTX2 | Mitochondrial biogenesis |
| GO:0005742 | 0.00109385703544 | 0.6 | SAMM50 IMMT MTX2 | mitochondrial outer membrane translocase complex |
| GO:0098799 | 0.00127603542925 | 0.6 | SAMM50 IMMT MTX2 | outer mitochondrial membrane protein complex |
| GO:0007007 | 0.0094606249379 | 0.6 | SAMM50 IMMT MTX2 | inner mitochondrial membrane organization |
| REAC:R-HSA-1852241 | 0.0104028281978 | 0.6 | SAMM50 IMMT MTX2 | Organelle biogenesis and maintenance |
| HPA:0241103 | 0.0109659799408 | 0.8 | TRAK1 IMMT MTX2 SAMM50 | heart muscle; cardiomyocytes[High] |
| KEGG:04137 | 0.0213229262457 | 0.4 | SAMM50 MTX2 | Mitophagy - animal |
| REAC:R-HSA-1268020 | 0.0266933781073 | 0.4 | SAMM50 MTX2 | Mitochondrial protein import |
| HPA:0360053 | 0.035740890287 | 0.8 | TRAK1 IMMT MTX2 SAMM50 | parathyroid gland; glandular cells[High] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| SAMM50 | MTX2 | 1.0 | 0.958 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 boldt_WMM |
| IMMT | MTX2 | 1.0 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt hein () bioplex3_HCT116 fraction boldt_WMM | ||
| SAMM50 | IMMT | 0.998 | hein_WMM bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | ||
| TRAK1 | SAMM50 | 0.997 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TRAK1 | IMMT | 0.993 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TRAK1 | MTX2 | 0.982 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| MTX2 | SLC2A8 | 0.97 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SAMM50 | SLC2A8 | 0.97 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| IMMT | SLC2A8 | 0.948 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM WMM_only |
Related Complexes